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Comprehensive globa...
Comprehensive global genome dynamics of Chlamydia trachomatis show ancient diversification followed by contemporary mixing and recent lineage expansion
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- Hadfield, James (författare)
- Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- Harris, Simon R (författare)
- Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- Seth-Smith, Helena M B (författare)
- Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom; Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland; Clinical Microbiology, University Hospital Basel, Basel, Switzerland
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- Parmar, Surendra (författare)
- Public Health England, Public Health Laboratory Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
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- Andersson, Patiyan (författare)
- Menzies School of Health Research, Darwin NT, Australia
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- Giffard, Philip M. (författare)
- Menzies School of Health Research, Darwin NT, Australia; School of Psychological and Clinical Sciences, Charles Darwin University, Darwin, Australia
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- Schachter, Julius (författare)
- Department of Laboratory Medicine, University of California, San Francisco CA, USA
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- Moncada, Jeanne (författare)
- Department of Laboratory Medicine, University of Californiao, San Francisco CA, USA
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- Ellison, Louise (författare)
- Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- Vaulet, María Lucía Gallo (författare)
- Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Microbiología Clínica, Universidad de Buenos Aires, Buenos Aires, Argentina
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- Fermepin, Marcelo Rodríguez (författare)
- Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Microbiología Clínica, Universidad de Buenos Aires, Buenos Aires, Argentina
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- Radebe, Frans (författare)
- Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
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- Mendoza, Suyapa (författare)
- Jefe Laboratorio de ITS, Laboratorio Nacional de Vigilancia, Honduras
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- Ouburg, Sander (författare)
- Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, Vrije University Medical Center, Amsterdam, The Netherlands
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- Morré, Servaas A (författare)
- Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, Vrije University Medical Center, Amsterdam, The Netherlands; Department of Genetics and Cell Biology, Institute of Public Health Genomics, School for Oncology & Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, University of Maastricht, Maastricht, The Netherlands
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- Sachse, Konrad (författare)
- Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut (Federal Research Institute for Animal Health), Jena, Germany
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- Puolakkainen, Mirja (författare)
- Department of Virology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
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- Korhonen, Suvi J (författare)
- Department of Virology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
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- Sonnex, Chris (författare)
- Public Health England, Public Health Laboratory Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
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- Wiggins, Rebecca (författare)
- Department of Biology, University of York, York, United Kingdom
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- Jalal, Hamid (författare)
- Public Health England, Public Health Laboratory Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
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- Brunelli, Tamara (författare)
- Clinical Chemistry and Microbiology Laboratory, Santo Stefano Hospital, Prato, Italy
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- Casprini, Patrizia (författare)
- Clinical Chemistry and Microbiology Laboratory, Santo Stefano Hospital, Prato, Italy
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- Pitt, Rachel (författare)
- Sexually Transmitted Bacteria Reference Unit, Microbiological Services, Public Health England, London, United Kingdom
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- Ison, Cathy (författare)
- Sexually Transmitted Bacteria Reference Unit, Microbiological Services, Public Health England, London, United Kingdom
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- Savicheva, Alevtina (författare)
- Laboratory of Microbiology, D.O. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg, Russia
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- Shipitsyna, Elena (författare)
- Laboratory of Microbiology, D.O. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg, Russia; WHO Collaborating Centre for Gonorrhoea and other STIs, Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden
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- Hadad, Ronza, 1984- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,WHO Collaborating Centre for Gonorrhoea and other STIs, Örebro University Hospital, Örebro, Sweden
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- Kari, Laszlo (författare)
- Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton Montana, USA
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- Burton, Matthew J (författare)
- Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom
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- Mabey, David (författare)
- Centre for Infectious Diseases and Microbiology, Sydney, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead Clinical School, University of Sydney, Sydney, Australia
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- Solomon, Anthony W (författare)
- Centre for Infectious Diseases and Microbiology, Sydney, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead Clinical School, University of Sydney, Sydney, Australia
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- Lewis, David (författare)
- Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; Centre for Infectious Diseases and Microbiology, Sydney, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead Clinical School, University of Sydney, Sydney, Australia
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- Marsh, Peter (författare)
- Public Health England, Public Health Laboratory Southampton, Southampton General Hospital, Southampton, United Kingdom
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- Unemo, Magnus, 1970- (författare)
- Örebro University, School of Medical Sciences; WHO Collaborating Centre for Gonorrhoea and other STIs, Örebro University Hospital, Örebro, Sweden
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- Clarke, Ian N (författare)
- Molecular Microbiology Group, University Medical School, Southampton General Hospital, Southampton, United Kingdom
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- Parkhill, Julian (författare)
- Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- Thomson, Nicholas R. (författare)
- Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom; Department of Pathogen Molecular Biology, The London School of Hygiene and Tropical Medicine, London, United Kingdom
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(creator_code:org_t)
- 2017-06-06
- 2017
- Engelska.
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Ingår i: Genome Research. - : Cold Spring Harbor Laboratory Press. - 1088-9051 .- 1549-5469. ; 27:7, s. 1220-1229
- Relaterad länk:
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https://doi.org/10.1...
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https://oru.diva-por... (primary) (Raw object)
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http://genome.cshlp....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Chlamydia trachomatis is the world's most prevalent bacterial sexually transmitted infection and leading infectious cause of blindness, yet it is one of the least understood human pathogens, in part due to the difficulties of in vitro culturing and the lack of available tools for genetic manipulation. Genome sequencing has reinvigorated this field, shedding light on the contemporary history of this pathogen. Here, we analyze 563 full genomes, 455 of which are novel, to show that the history of the species comprises two phases, and conclude that the currently circulating lineages are the result of evolution in different genomic ecotypes. Temporal analysis indicates these lineages have recently expanded in the space of thousands of years, rather than the millions of years as previously thought, a finding that dramatically changes our understanding of this pathogen's history. Finally, at a time when almost every pathogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of circulating genomic resistance in C. trachomatis.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
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Hadfield, James
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Harris, Simon R
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Seth-Smith, Hele ...
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Parmar, Surendra
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Andersson, Patiy ...
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Giffard, Philip ...
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visa fler...
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Schachter, Juliu ...
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Moncada, Jeanne
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Ellison, Louise
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Vaulet, María Lu ...
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Fermepin, Marcel ...
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Radebe, Frans
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Mendoza, Suyapa
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Ouburg, Sander
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Morré, Servaas A
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Sachse, Konrad
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Puolakkainen, Mi ...
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Korhonen, Suvi J
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Sonnex, Chris
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Wiggins, Rebecca
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Jalal, Hamid
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Brunelli, Tamara
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Casprini, Patriz ...
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Pitt, Rachel
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Ison, Cathy
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Savicheva, Alevt ...
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Shipitsyna, Elen ...
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Hadad, Ronza, 19 ...
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Kari, Laszlo
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Burton, Matthew ...
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Mabey, David
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Solomon, Anthony ...
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Lewis, David
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Marsh, Peter
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Unemo, Magnus, 1 ...
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Clarke, Ian N
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Parkhill, Julian
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Thomson, Nichola ...
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- NATURVETENSKAP
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NATURVETENSKAP
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Genome Research
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Örebro universitet