WFRF:(Schmid Gerhard)
Sökning: WFRF:(Schmid Gerhard) > Short-Term Exercise...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04157naa a2200469 4500 | |
| 001 | oai:lup.lub.lu.se:faa50a34-c0ce-4651-9133-1e8a6b504184 | |
| 003 | SwePub | |
| 008 | 160401s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/14252932 URI |
| 024 | 7 | a https://doi.org/10.2337/db08-12402 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Kacerovsky-Bielesz, Gertrud4 aut |
| 245 | 1 0 | a Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes |
| 264 | c 2009-03-05 | |
| 264 | 1 | b American Diabetes Association,c 2009 |
| 520 | a OBJECTIVE-We tested the hypothesis that short-term exercise training improves hereditary insulin resistance by stimulating ATP synthesis and investigated associations With gene polymorphisms. RESEARCH DESIGN AND METHODS-We studied 24 nono-bese first-degree relatives of type 2 diabetic patients and 12 control subjects at rest, and 48 h after three bouts of exercise. In addition to measurements of oxygen uptake and insulin sensitivity (oral glucose tolerance test), ectopic lipids and mitochondrial ATP synthesis were assessed using H-1 and P-31 magnetic resonance spectroscopy, respectively. They were genotyped for polymorphisms in genes regulating mitochondrial function, PPARGC1A (rs8192678) and NDUFB6 (rs540467). RESULTS-Relatives had slightly lower (P = 0.012) insulin sensitivity than control subjects. In control subjects, ATP synthase flux rose by 18% (P = 0.0001), being 23% higher (P = 0.002) than that in relatives after exercise training. Relatives responding to exercise training with increased ATP synthesis (+19%, P = 0.009) showed improved insulin sensitivity (P = 0.009) compared with those whose insulin sensitivity did not improve. A polymorphism in the NDUFB6 gene from respiratory chain complex I related to ATP synthesis (P = 0.02) and insulin Sensitivity response to exercise training (P = 0.05). ATP synthase flux correlated with O-2 uptake and insulin sensitivity. CONCLUSIONS-The ability of short-term exercise to stimulate ATP production distinguished individuals with improved insulin sensitivity from those whose insulin sensitivity did not improve. lit addition, the NDUFB6 gene polymorphism appeared to modulate this adaptation. This finding suggests that genes involved in mitochondrial function contribute to the response of ATP synthesis to exercise training. Diabetes 58:1333-1341, 2009 | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 700 | 1 | a Chmelik, Marek4 aut |
| 700 | 1 | a Ling, Charlotteu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-cl0 |
| 700 | 1 | a Pokan, Rochus4 aut |
| 700 | 1 | a Szendroedi, Julia4 aut |
| 700 | 1 | a Farukuoye, Michaela4 aut |
| 700 | 1 | a Kacerovsky, Michaela4 aut |
| 700 | 1 | a Schmid, Albrecht I.4 aut |
| 700 | 1 | a Gruber, Stephan4 aut |
| 700 | 1 | a Wolzt, Michael4 aut |
| 700 | 1 | a Moser, Ewald4 aut |
| 700 | 1 | a Pacini, Giovanni4 aut |
| 700 | 1 | a Smekal, Gerhard4 aut |
| 700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
| 700 | 1 | a Roden, Michael4 aut |
| 710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Diabetesd : American Diabetes Associationg 58:6, s. 1333-1341q 58:6<1333-1341x 1939-327Xx 0012-1797 |
| 856 | 4 | u http://dx.doi.org/10.2337/db08-1240x freey FULLTEXT |
| 856 | 4 | u http://diabetes.diabetesjournals.org/content/58/6/1333.full.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1425293 |
| 856 | 4 8 | u https://doi.org/10.2337/db08-1240 |
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