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Sökning: WFRF:(Sherman S) > (2005-2009) > What is a gene, pos...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003672naa a2200589 4500
001oai:DiVA.org:kth-50433
003SwePub
008111205s2007 | |||||||||||000 ||eng|
009oai:DiVA.org:su-11351
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-504332 URI
0247 a https://doi.org/10.1101/gr.63396072 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-113512 URI
040 a (SwePub)kthd (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gerstein, Mark B4 aut
2451 0a What is a gene, post-ENCODE? :b History and updated definition
264 c 2007-06-13
264 1b Cold Spring Harbor Laboratory,c 2007
338 a print2 rdacarrier
500 a QC 20111206
520 a While sequencing of the human genome surprised us with how many protein-coding genes there are, it did not fundamentally change our perspective on what a gene is. In contrast, the complex patterns of dispersed regulation and pervasive transcription uncovered by the ENCODE project, together with non-genic conservation and the abundance of noncoding RNA genes, have challenged the notion of the gene. To illustrate this, we review the evolution of operational definitions of a gene over the past century--from the abstract elements of heredity of Mendel and Morgan to the present-day ORFs enumerated in the sequence databanks. We then summarize the current ENCODE findings and provide a computational metaphor for the complexity. Finally, we propose a tentative update to the definition of a gene: A gene is a union of genomic sequences encoding a coherent set of potentially overlapping functional products. Our definition side-steps the complexities of regulation and transcription by removing the former altogether from the definition and arguing that final, functional gene products (rather than intermediate transcripts) should be used to group together entities associated with a single gene. It also manifests how integral the concept of biological function is in defining genes.
650 7a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng
653 a HIDDEN MARKOV MODEL
653 a CHIP-CHIP EXPERIMENTS
653 a GENOME TILING ARRAYS
653 a NONCODING RNAS
653 a MESSENGER-RNA
653 a TRANSCRIPTIONAL ACTIVITY
653 a PROCESSED PSEUDOGENES
653 a SYSTEMATIC DEFINITION
653 a UNRELATED PROTEINS
653 a PNEUMOCOCCAL TYPES
7001 a Bruce, Can4 aut
7001 a Rozowsky, Joel S4 aut
7001 a Zheng, Deyou4 aut
7001 a Du, Jiang4 aut
7001 a Korbel, Jan O4 aut
7001 a Emanuelsson, Olofu Stockholms universitet,Institutionen för biokemi och biofysik4 aut0 (Swepub:su)emanu
7001 a Zhang, Zhengdong D4 aut
7001 a Weissman, Sherman4 aut
7001 a Snyder, Michael4 aut
7102 a Stockholms universitetb Institutionen för biokemi och biofysik4 org
7730 t Genome Researchd : Cold Spring Harbor Laboratoryg 17:6, s. 669-681q 17:6<669-681x 1088-9051x 1549-5469
8564 u http://genome.cshlp.org/content/17/6/669.full.pdf
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17567988&dopt=Citation
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-50433
8564 8u https://doi.org/10.1101/gr.6339607
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-11351

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