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Frequent NFKBIE del...
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
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- Mansouri, Larry (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Richard Rosenquist
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- Noerenberg, Daniel (författare)
- Department of Hematology, Oncology, and Tumor Immunology, Charite, University Medical Center, Berlin, Germany
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- Young, Emma, 1990- (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Richard Rosenquist Brandell
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- Mylonas, Elena (författare)
- Department of Hematology, Oncology, and Tumor Immunology, Charite, University Medical Center, Berlin, Germany
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- Abdulla, Maysaa (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Rose-Marie Amini
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- Frick, Mareike (författare)
- Department of Hematology, Oncology, and Tumor Immunology, Charite, University Medical Center, Berlin, Germany
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- Asmar, Fazila (författare)
- Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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- Ljungström, Viktor (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
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- Schneider, Markus (författare)
- Institute of Cell Biology (Cancer Research), Faculty of Medicine, University of Duisburg-Essen, Essen, Germany
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- Yoshida, Kenichi (författare)
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Skaftason, Aron (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
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- Pandzic, Tatjana (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
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- Gonzalez, Blanca (författare)
- Department of Pathology, Hospital Clinic and Institut d’Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
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- Tasidou, Anna (författare)
- Hematopathology Department, Evangelismos Hospital, Athens, Greece
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- Waldhueter, Nils (författare)
- Department of Hematology, Oncology, and Tumor Immunology, Charite, University Medical Center, Berlin, Germany
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- Rivas-Delgado, Alfredo (författare)
- Hematology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain
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- Angelopoulou, Maria (författare)
- Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
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- Ziepert, Marita (författare)
- Institute for Medical Informatics, Statistics, and Epidemiology, University at Leipzig, Leipzig, Germany
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- Arends, Christopher-Maximilian (författare)
- Department of Hematology, Oncology, and Tumor Immunology, Charite, University Medical Center, Berlin, Germany
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- Couronne, Lucile (författare)
- Service d’Hematologie Adulte, Assistance Publique–Hopitaux de Paris, Hopital Necker, Paris, France
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- Lenze, Dido (författare)
- Institute of Pathology, Charite University Medical Center, Berlin, Germany
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- Claudia, Baldus (författare)
- Department of Hematology, Oncology, and Tumor Immunology, Charite, University Medical Center, Berlin, Germany
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- Bastard, Christian (författare)
- INSERM U918, Universite de Rouen, Centre Henri Becquerel, Rouen, France
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- Okosun, Jessica (författare)
- Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
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- Fitzgibbon, Jude (författare)
- Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
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- Dörken, Bernd (författare)
- Department of Hematology, Oncology, and Tumor Immunology, Charite, University Medical Center, Berlin, Germany
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- Drexler, Hans G (författare)
- Leibniz-Institute DSMZ–German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
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- Roos-Weil, Damien (författare)
- University Paris-Sud, Orsay, France, INSERM, U1170, Institut Gustave Roussy, Villejuif, France and Equipe Labellisee Ligue Nationale Contre le Cancer, Paris, France
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- Schmitt, Clemens A (författare)
- Department of Hematology, Oncology, and Tumor Immunology, Charite, University Medical Center, Berlin, Germany
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- Munch-Petersen, Helga D (författare)
- Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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- Zenz, Thorsten (författare)
- Departments of Molecular Therapy in Haematology and Oncology and Translational Oncology, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany, Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany and German Consortium for Translational Cancer Research, Heidelberg, Germany
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- Hansmann, Martin-Leo (författare)
- Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany
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- Strefford, Jonathan C (författare)
- Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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- Enblad, Gunilla (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab
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- Bernard, Olivier (författare)
- University Paris-Sud, Orsay, France, INSERM, U1170, Institut Gustave Roussy, Villejuif, France and Equipe Labellisee Ligue Nationale Contre le Cancer, Paris, France
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- Ralfkiaer, Elisabeth (författare)
- Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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- Erlanson, Martin (författare)
- Umeå universitet,Onkologi,Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
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- Korkolopoulou, Penelope (författare)
- Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
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- Hultdin, Magnus (författare)
- Umeå universitet,Patologi,Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden
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- Papadaki, Theodora (författare)
- Hematopathology Department, Evangelismos Hospital, Athens, Greece,Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
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- Grønbæk, Kirsten (författare)
- Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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- Lopez-Guillermo, Armando (författare)
- Hematology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain
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- Ogawa, Seishi (författare)
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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- Küppers, Ralf (författare)
- Institute of Cell Biology (Cancer Research), Faculty of Medicine, University of Duisburg-Essen, Essen, Germany
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- Stamatopoulos, Kostas (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Institute of Applied Biosciences, Center for Research and Technology Hellas, Thessaloniki, Greece
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- Stavroyianni, Niki (författare)
- Hematology Department and Hematopoietic Cell Transplantation Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
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- Kanellis, George (författare)
- Hematopathology Department, Evangelismos Hospital, Athens, Greece
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- Rosenwald, Andreas (författare)
- Institute of Pathology, University of Würzburg, Würzburg, Germany and Comprehensive Cancer Center Mainfranken, Würzburg, Germany
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- Campo, Elias (författare)
- Department of Pathology, Hospital Clinic and Institut d’Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
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- Amini, Rose-Marie (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Rose-Marie Amini
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- Ott, German (författare)
- Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
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- Vasslakopoulos, Theodoros P (författare)
- Department of Haematology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
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- Hummel, Michael (författare)
- Institute of Pathology, Charite University Medical Center, Berlin, Germany
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- Rosenquist, Richard (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
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- Damm, Frederik (författare)
- Department of Hematology, Oncology, and Tumor Immunology, Charite, University Medical Center, Berlin, Germany and Berlin Institute of Health, Berlin, Germany
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Gronbaek, Kirsten (författare)
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(creator_code:org_t)
- American Society of Hematology, 2016
- 2016
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 128:23, s. 2666-2670
- Relaterad länk:
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https://eprints.soto...
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visa fler...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We recently reported a truncating deletion in the NFKBIE gene, which encodes IκBϵ, a negative feedback regulator of NF-κB, in clinically aggressive chronic lymphocytic leukemia (CLL). Preliminary data indicate enrichment of NFKBIE aberrations in other lymphoid malignancies, hence we screened a large patient cohort (n=1460) diagnosed with different lymphoid neoplasms. While NFKBIE deletions were infrequent in follicular lymphoma, splenic marginal-zone lymphoma, and T-cell acute lymphoblastic leukemia (<2%), slightly higher frequencies were seen in diffuse large B-cell lymphoma, mantle cell lymphoma, and primary CNS lymphoma (3-4%). In contrast, a remarkably high frequency of NFKBIE aberrations (46/203 cases, 22.7%) was observed in primary mediastinal B-cell lymphoma (PMBL) and Hodgkin lymphoma (3/11 cases, 27.3%). NFKBIE-deleted PMBL patients were more often therapy-refractory (P=.022) and displayed inferior outcome compared to wildtype patients (5-year survival: 59% vs. 78%; P=.034); however they appeared to benefit from radiotherapy (P=.022) and rituximab-containing regimens (P=.074). NFKBIEaberrations remained an independent factor in multivariate analysis (P=.003), also when restricting to immunochemotherapy-treated patients (P=.008). Whole-exome sequencing and gene expression-profiling verified the importance of NF-κB deregulation in PMBL. In summary, we identify NFKBIE aberrations as a common genetic event across B-cell malignancies and highlight NFKBIE deletions as a novel poor-prognostic marker in PMBL.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Molekylär genetik
- Molecular Genetics
- Pathology
- Patologi
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- ref (ämneskategori)
- art (ämneskategori)
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Blood
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Mansouri, Larry
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Noerenberg, Dani ...
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Young, Emma, 199 ...
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Mylonas, Elena
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Abdulla, Maysaa
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Frick, Mareike
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visa fler...
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Asmar, Fazila
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Ljungström, Vikt ...
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Schneider, Marku ...
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Yoshida, Kenichi
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Skaftason, Aron
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Pandzic, Tatjana
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Gonzalez, Blanca
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Tasidou, Anna
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Waldhueter, Nils
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Rivas-Delgado, A ...
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Angelopoulou, Ma ...
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Ziepert, Marita
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Arends, Christop ...
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Couronne, Lucile
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Lenze, Dido
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Claudia, Baldus
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Bastard, Christi ...
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Okosun, Jessica
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Fitzgibbon, Jude
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Dörken, Bernd
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Drexler, Hans G
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Roos-Weil, Damie ...
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Schmitt, Clemens ...
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Munch-Petersen, ...
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Zenz, Thorsten
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Hansmann, Martin ...
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Strefford, Jonat ...
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Enblad, Gunilla
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Bernard, Olivier
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Ralfkiaer, Elisa ...
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Erlanson, Martin
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Korkolopoulou, P ...
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Hultdin, Magnus
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Papadaki, Theodo ...
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Grønbæk, Kirsten
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Lopez-Guillermo, ...
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Ogawa, Seishi
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Küppers, Ralf
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Stamatopoulos, K ...
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Stavroyianni, Ni ...
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Kanellis, George
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Rosenwald, Andre ...
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Campo, Elias
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Amini, Rose-Mari ...
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Ott, German
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Vasslakopoulos, ...
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Hummel, Michael
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Rosenquist, Rich ...
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Damm, Frederik
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Gronbaek, Kirste ...
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