Multiple functions of the new cytokine-based antimicrobial peptide thymic stromal lymphopoietin (TSLP)

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Fältnamn	Indikatorer	Metadata
000		03586naa a2200385 4500
001		oai:lup.lub.lu.se:b23dc74d-b01e-415a-9358-97ab4776178d
003		SwePub
008		161123s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/b23dc74d-b01e-415a-9358-97ab4776178d2 URI
024	7	a https://doi.org/10.3390/ph90300412 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a for2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Bjerkan, Louiseu University of Oslo4 aut
245	1 0	a Multiple functions of the new cytokine-based antimicrobial peptide thymic stromal lymphopoietin (TSLP)
264		c 2016-07-05
264	1	b MDPI AG,c 2016
520		a Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine, hitherto mostly known to be involved in inflammatory responses and immunoregulation. The human tslp gene gives rise to two transcription and translation variants: a long form (lfTSLP) that is induced by inflammation, and a short, constitutively-expressed form (sfTSLP), that appears to be downregulated by inflammation. The TSLP forms can be produced by a number of cell types, including epithelial and dendritic cells (DCs). lfTSLP can activate mast cells, DCs, and T cells through binding to the lfTSLP receptor (TSLPR) and has a pro-inflammatory function. In contrast, sfTSLP inhibits cytokine secretion of DCs, but the receptor mediating this effect is unknown. Our recent studies have demonstrated that both forms of TSLP display potent antimicrobial activity, exceeding that of many other known antimicrobial peptides (AMPs), with sfTSLP having the strongest effect. The AMP activity is primarily mediated by the C-terminal region of the protein and is localized within a 34-mer peptide (MKK34) that spans the C-terminal α-helical region in TSLP. Fluorescent studies of peptide-treated bacteria, electron microscopy, and liposome leakage models showed that MKK34 exerted membrane-disrupting effects comparable to those of LL-37. Expression of TSLP in skin, oral mucosa, salivary glands, and intestine is part of the defense barrier that aids in the control of both commensal and pathogenic microbes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653		a AMP
653		a Immunoregulation
653		a TSLP
700	1	a Sonesson, Andreasu Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)derm-aso
700	1	a Schenck, Karlu University of Oslo4 aut
710	2	a University of Oslob Dermatologi och venereologi, Lund4 org
773	0	t Pharmaceuticalsd : MDPI AGg 9:3q 9:3x 1424-8247
856	4	u http://dx.doi.org/10.3390/ph9030041x freey FULLTEXT
856	4	u https://www.mdpi.com/1424-8247/9/3/41/pdf
856	4 8	u https://lup.lub.lu.se/record/b23dc74d-b01e-415a-9358-97ab4776178d
856	4 8	u https://doi.org/10.3390/ph9030041

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Av författaren/redakt...: Bjerkan, Louise; Sonesson, Andrea ...; Schenck, Karl

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