Non-invasive evaluation of the effect of metoprolol on the atrioventricular node during permanent atrial fibrillation

Sandberg, Frida (författare): Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Avdelningen för Biomedicinsk teknik,Medicin och teknik (CI),Utbildningsprogram, LTH,Faculty of Engineering, LTH,Biomedical Engineering (M.Sc.Eng.),Educational programmes, LTH,Faculty of Engineering, LTH

Platonov, Pyotr G. (författare): Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine

Sornmo, Leif (författare): Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Avdelningen för Biomedicinsk teknik,Medicin och teknik (CI),Utbildningsprogram, LTH,Faculty of Engineering, LTH,Biomedical Engineering (M.Sc.Eng.),Educational programmes, LTH,Faculty of Engineering, LTH

(creator_code:org_t)

January
2014-10-31
2014
Engelska 4 s.
Ingår i: Computing in Cardiology 2014. - : Oxford University Press (OUP). - 2325-8861. - 9781479943463 - 9781479943470 ; 41, s. 889-892

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Abstract Ämnesord

Stäng

The aim of this study was to evaluate changes in AV nodal properties during administration of metoprolol, using a novel ECG-based method for parameter estimation. The AV nodal parameters account for the probability of an impulse not passing through the fast pathway, the absolute refractory periods of the slow and fast pathways (aRPs and aRPf), representing the functional refractory period, and related prolongation in the respective refractory periods. Twenty patients (age 71±8 years, 14 men) with permanent AF from the RATe control in Atrial Fibrillation (RATAF) database were included in this study. Recordings during baseline and metoprolol administration were analyzed. Furthermore, simulated RR series were generated mimicking metoprolol administration. During metoprolol administration, aRP was significantly prolonged in both pathways (aRPs: 342±39 vs. 408±81 ms, p<0.001; aRPf: 432±74 vs. 527±83 ms, p<0.001). Similar results were found for the simulated RR series: both aRPs and aRPf were significantly prolonged with metoprolol. The AV nodal parameters reflect expected changes after metoprolol administration, i.e., a prolongation in functional refractory period. The simulations suggest that aRP may serve as an estimate of the functional refractory period.

Av författaren/redakt...: Corino, Valentin ...; Sandberg, Frida; Mainardi, Luca T ...; Ulimoen, Sara R.; Enger, Steve; Tveit, Arnljot; visa fler...; Platonov, Pyotr ...; Sornmo, Leif; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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