Sökning: WFRF:(Thomopoulos Thomas P.) >
Comorbidity of Cogn...
-
Georgakis, Marios K
(författare)
Comorbidity of Cognitive Impairment and Late-Life Depression Increase Mortality : Results From a Cohort of Community-Dwelling Elderly Individuals in Rural Greece
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
-
2016-02-25
-
SAGE Publications,2016
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-279109
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-279109URI
-
https://doi.org/10.1177/0891988716632913DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
OBJECTIVE: To investigate the association of cognitive impairment (COGI) and depression with all-cause mortality and cardiovascular-specific mortality among community-dwelling elderly individuals in rural Greece.METHODS: Cognition and depressive symptomatology of 676 Velestino town residents aged ≥60 years were assessed using Mini-Mental State Examination (MMSE) and Geriatric Depression Scale (GDS), respectively. Eight-year all-cause mortality and cardiovascular mortality were explored by multivariate Cox regression models controlling for major confounders.RESULTS: Two hundred and one patients died during follow-up. Cognitive impairment (MMSE ≤ 23) was independently associated with all-cause mortality (hazard ratio [HR]: 1.57, 95% confidence interval [CI]: 1.13-2.18) and cardiovascular mortality (HR: 1.57, 95%CI: 1.03-2.41). Moderate to severe depression (GDS > 10) was significantly associated only with a 51% increase in all-cause mortality. A male-specific association was noted for moderate to severe depression, whereas the effect of COGI was limited to females. Noteworthy, COGI and depression comorbidity, rather than their sole presence, increased all-cause mortality and cardiovascular mortality by 66% and 72%, respectively. The mortality effect of COGI was augmented among patients with depression and of depression among patients with COGI.CONCLUSION: COGI and depression, 2 entities often coexisting among elderly individuals, appear to increase all-cause mortality and cardiovascular mortality. Gender-specific modes may prevail but their comorbidity should be carefully assessed, as it seems to represent an independent index of increased frailty, which eventually shortens life expectancy.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Papadopoulos, Fotios CUppsala universitet,Psykiatri, Akademiska sjukhuset(Swepub:uu)fotpa105
(författare)
-
Protogerou, Athanasios D
(författare)
-
Pagonari, Ioanna
(författare)
-
Sarigianni, Fani
(författare)
-
Biniaris-Georgallis, Stylianos-Iason
(författare)
-
Kalogirou, Eleni I
(författare)
-
Thomopoulos, Thomas P
(författare)
-
Kapaki, Elisabeth
(författare)
-
Papageorgiou, Charalampos
(författare)
-
Papageorgiou, Socratis G
(författare)
-
Tousoulis, Dimitrios
(författare)
-
Petridou, Eleni Th
(författare)
-
Uppsala universitetPsykiatri, Akademiska sjukhuset
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Geriatric Psychiatry and Neurology: SAGE Publications29:4, s. 195-2040891-98871552-5708
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Georgakis, Mario ...
-
Papadopoulos, Fo ...
-
Protogerou, Atha ...
-
Pagonari, Ioanna
-
Sarigianni, Fani
-
Biniaris-Georgal ...
-
visa fler...
-
Kalogirou, Eleni ...
-
Thomopoulos, Tho ...
-
Kapaki, Elisabet ...
-
Papageorgiou, Ch ...
-
Papageorgiou, So ...
-
Tousoulis, Dimit ...
-
Petridou, Eleni ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Psykiatri
- Artiklar i publikationen
-
Journal of Geria ...
- Av lärosätet
-
Uppsala universitet