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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006257naa a2200721 4500
001oai:lup.lub.lu.se:3c22252f-a184-4a4c-a718-dd4dd5d6ae25
003SwePub
008240112s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:151517526
0247 a https://lup.lub.lu.se/record/3c22252f-a184-4a4c-a718-dd4dd5d6ae252 URI
0247 a https://doi.org/10.1002/ehf2.142612 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1515175262 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Radhoe, Sumant P.u Erasmus University Medical Center4 aut
2451 0a Sex-related differences in left ventricular assist device utilization and outcomes : results from the PCHF-VAD registry
264 c 2022-12-22
264 1b Wiley,c 2023
300 a 12 s.
520 a Aims: Data on sex and left ventricular assist device (LVAD) utilization and outcomes have been conflicting and mostly confined to US studies incorporating older devices. This study aimed to investigate sex-related differences in LVAD utilization and outcomes in a contemporary European LVAD cohort. Methods and results: This analysis is part of the multicentre PCHF-VAD registry studying continuous-flow LVAD patients. The primary outcome was all-cause mortality. Secondary outcomes included ventricular arrhythmias, right ventricular failure, bleeding, thromboembolism, and the haemocompatibility score. Multivariable Cox regression models were used to assess associations between sex and outcomes. Overall, 457 men (81%) and 105 women (19%) were analysed. At LVAD implant, women were more often in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 or 2 (55% vs. 41%, P = 0.009) and more often required temporary mechanical circulatory support (39% vs. 23%, P = 0.001). Mean age was comparable (52.1 vs. 53.4 years, P = 0.33), and median follow-up duration was 344 [range 147–823] days for women and 435 [range 190–816] days for men (P = 0.40). No significant sex-related differences were found in all-cause mortality (hazard ratio [HR] 0.79 for female vs. male sex, 95% confidence interval [CI] [0.50–1.27]). Female LVAD patients had a lower risk of ventricular arrhythmias (HR 0.56, 95% CI [0.33–0.95]) but more often experienced right ventricular failure. No significant sex-related differences were found in other outcomes. Conclusions: In this contemporary European cohort of LVAD patients, far fewer women than men underwent LVAD implantation despite similar clinical outcomes. This is important as the proportion of female LVAD patients (19%) was lower than the proportion of females with advanced HF as reported in previous studies, suggesting underutilization. Also, female patients were remarkably more often in INTERMACS profile 1 or 2, suggesting later referral for LVAD therapy. Additional research in female patients is warranted.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Advanced heart failure
653 a Left ventricular assist device
653 a Sex
653 a Survival
653 a Utilization
7001 a Jakus, Ninau University Hospital of Infectious Diseases4 aut
7001 a Veenis, Jesse F.u University Hospital of Infectious Diseases4 aut
7001 a Timmermans, Philippeu University Hospitals Leuven4 aut
7001 a Pouleur, Anne Catherineu Catholic University of Louvain,Saint-Luc University Hospital4 aut
7001 a Rubís, Pawelu Jagiellonian University4 aut
7001 a Van Craenenbroeck, Emeline M.u Antwerp University Hospital4 aut
7001 a Gaizauskas, Edvinasu Vilnius University4 aut
7001 a Barge-Caballero, Eduardou Hospital Juan Canalejo4 aut
7001 a Paolillo, Stefaniau University of Naples Federico II4 aut
7001 a Grundmann, Sebastianu Albert-Ludwigs University Freiburg4 aut
7001 a D'Amario, Domenicou Policlinico Universitario Agostino Gemelli4 aut
7001 a Braun, Oscaru Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kard-oos
7001 a Gkouziouta, Aggelikiu Onassis Cardiac Surgery Center, Athens4 aut
7001 a Planinc, Ivou University Hospital of Infectious Diseases4 aut
7001 a Macek, Jana Ljubasu University Hospital of Infectious Diseases4 aut
7001 a Meyns, Bartu University Hospitals Leuven4 aut
7001 a Droogne, Walteru University Hospitals Leuven4 aut
7001 a Wierzbicki, Karolu Jagiellonian University4 aut
7001 a Holcman, Katarzynau Jagiellonian University4 aut
7001 a Flammer, Andreas J.u University Hospital of Zurich4 aut
7001 a Gasparovic, Hrvojeu University Hospital of Infectious Diseases4 aut
7001 a Biocina, Bojanu University Hospital of Infectious Diseases4 aut
7001 a Milicic, Davoru University Hospital of Infectious Diseases4 aut
7001 a Lund, Lars Hu Karolinska Institutet,Karolinska Institute4 aut
7001 a Ruschitzka, Franku University Hospital of Zurich4 aut
7001 a Brugts, Jasper J.u Erasmus University Medical Center4 aut
7001 a Cikes, Majau University Hospital of Infectious Diseases4 aut
7102 a Erasmus University Medical Centerb University Hospital of Infectious Diseases4 org
7730 t ESC Heart Failured : Wileyg 10:2, s. 1054-1065q 10:2<1054-1065x 2055-5822
8564 u http://dx.doi.org/10.1002/ehf2.14261x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/3c22252f-a184-4a4c-a718-dd4dd5d6ae25
8564 8u https://doi.org/10.1002/ehf2.14261
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:151517526

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