Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort

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Fältnamn	Indikatorer	Metadata
000		06937naa a2201141 4500
001		oai:lup.lub.lu.se:170c3928-b7bb-4060-acb2-2c8679335003
003		SwePub
008		160401s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:slubar.slu.se:55520
009		oai:prod.swepub.kib.ki.se:127184659
009		oai:DiVA.org:umu-80045
024	7	a https://lup.lub.lu.se/record/40272032 URI
024	7	a https://doi.org/10.1093/aje/kwt0262 DOI
024	7	a https://res.slu.se/id/publ/555202 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1271846592 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-800452 URI
040		a (SwePub)lud (SwePub)slud (SwePub)kid (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Vermeulen, Esther4 aut
245	1 0	a Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort
264		c 2013-05-06
264	1	b Oxford University Press (OUP),c 2013
520		a We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer cases, of which 142 were esophageal adenocarcinoma (EAC), 176 were esophageal squamous cell carcinoma (ESCC), and 23 were other types of esophageal cancer. In crude models, a doubling in total dietary flavonoid intake was inversely associated with esophageal cancer risk (hazard ratio (HR) (log(2))=0.87, 95% confidence interval (CI): 0.78, 0.98) but not in multi-variable models (HR (log(2))=0.97, 95% CI: 0.86, 1.10). After covariate adjustment, no statistically significant association was found between any flavonoid subclass and esophageal cancer, EAC, or ESCC. However, among current smokers, flavonols were statistically significantly associated with a reduced esophageal cancer risk (HR (log(2)) = 0.72, 95% CI: 0.56, 0.94), whereas total flavonoids, flavanols, and flavan-3-ol monomers tended to be inversely associated with esophageal cancer risk. No associations were found in either never or former smokers. These findings suggest that dietary flavonoid intake was not associated with overall esophageal cancer, EAC, or ESCC risk, although total flavonoids and some flavonoid subclasses, particularly flavonols, may reduce the esophageal cancer risk among current smokers.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a esophageal cancer
653		a European Prospective Investigation into Cancer and
653		a Nutrition
653		a flavonoids
653		a intake
700	1	a Zamora-Ros, Raul4 aut
700	1	a Duell, Eric J.4 aut
700	1	a Lujan-Barroso, Leila4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Aleksandrova, Krasimira4 aut
700	1	a Bueno-de-Mesquita, H. Bas4 aut
700	1	a Scalbert, Augustin4 aut
700	1	a Romieu, Isabelle4 aut
700	1	a Fedirko, Veronika4 aut
700	1	a Touillaud, Marina4 aut
700	1	a Fagherazzi, Guy4 aut
700	1	a Perquier, Florence4 aut
700	1	a Molina-Montes, Esther4 aut
700	1	a Chirlaque, Maria-Dolores4 aut
700	1	a Argueelles, Marcial Vicente4 aut
700	1	a Amiano, Pilar4 aut
700	1	a Barricarte, Aurelio4 aut
700	1	a Pala, Valeria4 aut
700	1	a Mattiello, Amalia4 aut
700	1	a Saieva, Calogero4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Ricceri, Fulvio4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Vasilopoulou, Effie4 aut
700	1	a Ziara, Gianna4 aut
700	1	a Crowe, Francesca L.4 aut
700	1	a Khaw, Kay-Thee4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Vasilopoulou, Effie4 aut
700	1	a Ziara, Gianna4 aut
700	1	a Crowe, Francesca L.4 aut
700	1	a Khaw, Kay-Thee4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Lukanova, Annekatrin4 aut
700	1	a Grote, Verena A.4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Halkjaer, Jytte4 aut
700	1	a Bredsdorff, Lea4 aut
700	1	a Overvad, Kim4 aut
700	1	a Siersema, Peter D.4 aut
700	1	a Peeters, Petra H. M.4 aut
700	1	a May, Anne M.4 aut
700	1	a Weiderpass, Elisabeteu Karolinska Institutet4 aut
700	1	a Skeie, Guri4 aut
700	1	a Hjartaker, Anette4 aut
700	1	a Landberg, Rikardu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science4 aut0 (Swepub:slu)51036
700	1	a Johansson, Ingegerdu Umeå universitet,Tandläkarutbildning4 aut0 (Swepub:umu)injo0003
700	1	a Sonestedt, Emilyu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso
700	1	a Ericson, Ulrikau Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)medf-upe
700	1	a Riboli, Elio4 aut
700	1	a Gonzalez, Carlos A.4 aut
710	2	a Karolinska Institutetb Institutionen för livsmedelsvetenskap4 org
710	2	a Sveriges lantbruksuniversitet
773	0	t American Journal of Epidemiologyd : Oxford University Press (OUP)g 178:4, s. 570-581q 178:4<570-581x 0002-9262x 1476-6256
856	4	u http://dx.doi.org/10.1093/aje/kwt026y FULLTEXT
856	4	u https://academic.oup.com/aje/article-pdf/178/4/570/633114/kwt026.pdf
856	4 8	u https://lup.lub.lu.se/record/4027203
856	4 8	u https://doi.org/10.1093/aje/kwt026
856	4 8	u https://res.slu.se/id/publ/55520
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:127184659
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80045

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Av författaren/redakt...: Vermeulen, Esthe ...; Zamora-Ros, Raul; Duell, Eric J.; Lujan-Barroso, L ...; Boeing, Heiner; Aleksandrova, Kr ...; visa fler...; Bueno-de-Mesquit ...; Scalbert, August ...; Romieu, Isabelle; Fedirko, Veronik ...; Touillaud, Marin ...; Fagherazzi, Guy; Perquier, Floren ...; Molina-Montes, E ...; Chirlaque, Maria ...; Argueelles, Marc ...; Amiano, Pilar; Barricarte, Aure ...; Pala, Valeria; Mattiello, Amali ...; Saieva, Calogero; Tumino, Rosario; Ricceri, Fulvio; Trichopoulou, An ...; Vasilopoulou, Ef ...; Ziara, Gianna; Crowe, Francesca ...; Khaw, Kay-Thee; Wareham, Nichola ...; Lukanova, Anneka ...; Grote, Verena A.; Tjonneland, Anne; Halkjaer, Jytte; Bredsdorff, Lea; Overvad, Kim; Siersema, Peter ...; Peeters, Petra H ...; May, Anne M.; Weiderpass, Elis ...; Skeie, Guri; Hjartaker, Anett ...; Landberg, Rikard; Johansson, Ingeg ...; Sonestedt, Emily; Ericson, Ulrika; Riboli, Elio; Gonzalez, Carlos ...; visa färre...

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