A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk

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Fältnamn	Indikatorer	Metadata
000		05256naa a2200901 4500
001		oai:DiVA.org:umu-105269
003		SwePub
008		150622s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:131341745
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1052692 URI
024	7	a https://doi.org/10.1093/jnci/djv0102 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1313417452 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Aleksandrova, Krasimira4 aut
245	1 0	a A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk
264		c 2015-02-24
264	1	b Oxford University Press,c 2015
338		a print2 rdacarrier
520		a Background: Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. Results: After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P-difference = .87) and after excluding case patients diagnosed within the first four follow-up years. Conclusions: These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Chuang, Shu-Chun4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Zuo, Hui4 aut
700	1	a Tell, Grethe S4 aut
700	1	a Pischon, Tobias4 aut
700	1	a Jenab, Mazda4 aut
700	1	a Bueno-de-Mesquita, Bas4 aut
700	1	a Vollset, Stein Emil4 aut
700	1	a Midttun, Øivind4 aut
700	1	a Ueland, Per Magne4 aut
700	1	a Fedirko, Veronika4 aut
700	1	a Johansson, Mattias4 aut
700	1	a Weiderpass, Elisabeteu Karolinska Institutet4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Racine, Antoine4 aut
700	1	a Boutron-Ruault, Marie-Christine4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Kühn, Tilman4 aut
700	1	a Tjønneland, Anne4 aut
700	1	a Overvad, Kim4 aut
700	1	a Quirós, J Ramón4 aut
700	1	a Jakszyn, Paula4 aut
700	1	a Sánchez, María-José4 aut
700	1	a Dorronsoro, Miren4 aut
700	1	a Chirlaque, Maria-Dolores4 aut
700	1	a Ardanaz, Eva4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Wareham, Nicholas J4 aut
700	1	a Travis, Ruth C4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Lagiou, Pagona4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Palli, Domenico4 aut
700	1	a Sieri, Sabina4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Panico, Salvatore4 aut
700	1	a May, Anne M4 aut
700	1	a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001
700	1	a Ljuslinder, Ingridu Umeå universitet,Onkologi4 aut0 (Swepub:umu)inlj0001
700	1	a Kong, So Yeon J4 aut
700	1	a Freisling, Heinz4 aut
700	1	a Gunter, Marc J4 aut
700	1	a Lu, Yunxiau Karolinska Institutet4 aut
700	1	a Cross, Amanda J4 aut
700	1	a Riboli, Elio4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Midttun, O4 aut
710	2	a Karolinska Institutetb Patologi4 org
773	0	t Journal of the National Cancer Instituted : Oxford University Pressg 107:4q 107:4x 0027-8874x 1460-2105
856	4	u https://academic.oup.com/jnci/article-pdf/107/4/djv010/17314224/djv010.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-105269
856	4 8	u https://doi.org/10.1093/jnci/djv010
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:131341745

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Av författaren/redakt...: Aleksandrova, Kr ...; Chuang, Shu-Chun; Boeing, Heiner; Zuo, Hui; Tell, Grethe S; Pischon, Tobias; visa fler...; Jenab, Mazda; Bueno-de-Mesquit ...; Vollset, Stein E ...; Midttun, Øivind; Ueland, Per Magn ...; Fedirko, Veronik ...; Johansson, Matti ...; Weiderpass, Elis ...; Severi, Gianluca; Racine, Antoine; Boutron-Ruault, ...; Kaaks, Rudolf; Kühn, Tilman; Tjønneland, Anne; Overvad, Kim; Quirós, J Ramón; Jakszyn, Paula; Sánchez, María-J ...; Dorronsoro, Mire ...; Chirlaque, Maria ...; Ardanaz, Eva; Khaw, Kay-Tee; Wareham, Nichola ...; Travis, Ruth C; Trichopoulou, An ...; Lagiou, Pagona; Trichopoulos, Di ...; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Panico, Salvator ...; May, Anne M; Palmqvist, Richa ...; Ljuslinder, Ingr ...; Kong, So Yeon J; Freisling, Heinz; Gunter, Marc J; Lu, Yunxia; Cross, Amanda J; Riboli, Elio; Vineis, Paolo; Midttun, O; visa färre...

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