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Trans-omics biomark...
Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma
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- Dong, Xuesi (författare)
- Nanjing Medical University,Southeast University
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- Zhang, Ruyang (författare)
- Harvard University,Nanjing Medical University,Nanjing University
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- He, Jieyu (författare)
- Nanjing Medical University
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- Lai, Linjing (författare)
- Nanjing Medical University
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- Alolga, Raphael N. (författare)
- China Pharmaceutical University
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- Shen, Sipeng (författare)
- Nanjing Medical University,Harvard University
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- Zhu, Ying (författare)
- Nanjing Medical University
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- You, Dongfang (författare)
- Nanjing Medical University
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- Lin, Lijuan (författare)
- Nanjing Medical University
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- Chen, Chao (författare)
- Nanjing Medical University
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- Zhao, Yang (författare)
- Nanjing Medical University
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- Duan, Weiwei (författare)
- Nanjing Medical University
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- Su, Li (författare)
- Nanjing Medical University,Harvard University
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- Shafer, Andrea (författare)
- Massachusetts General Hospital,Harvard University
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- Salama, Moran (författare)
- Bellvitge Biomedical Research Institute,University of Barcelona
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- Fleischer, Thomas (författare)
- Oslo university hospital
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- Bjaanæs, Maria Moksnes (författare)
- Oslo university hospital
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- Karlsson, Anna (författare)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups
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- Planck, Maria (författare)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups
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- Wang, Rui (författare)
- Nanjing University
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- Staaf, Johan (författare)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups
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- Helland, Åslaug (författare)
- Oslo university hospital,University of Oslo
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- Esteller, Manel (författare)
- Bellvitge Biomedical Research Institute,University of Barcelona
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- Wei, Yongyue (författare)
- Nanjing Medical University,Harvard University
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- Chen, Feng (författare)
- Nanjing Medical University,Southeast University
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- Christiani, David C. (författare)
- Harvard University,Massachusetts General Hospital,Nanjing Medical University
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(creator_code:org_t)
- 2019-08-21
- 2019
- Engelska 24 s.
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Ingår i: Aging. - : Impact Journals, LLC. - 1945-4589. ; 11:16, s. 6312-6335
- Relaterad länk:
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http://dx.doi.org/10... (free)
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visa fler...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Limited studies have focused on developing prognostic models with trans-omics biomarkers for early-stage lung adenocarcinoma (LUAD). We performed integrative analysis of clinical information, DNA methylation, and gene expression data using 825 early-stage LUAD patients from 5 cohorts. Ranger algorithm was used to screen prognosis-associated biomarkers, which were confirmed with a validation phase. Clinical and biomarker information was fused using an iCluster plus algorithm, which significantly distinguished patients into high- and low-mortality risk groups (Pdiscovery = 0.01 and Pvalidation = 2.71×10-3). Further, potential functional DNA methylation-gene expression-overall survival pathways were evaluated by causal mediation analysis. The effect of DNA methylation level on LUAD survival was significantly mediated through gene expression level. By adding DNA methylation and gene expression biomarkers to a model of only clinical data, the AUCs of the trans-omics model improved by 18.3% (to 87.2%) and 16.4% (to 85.3%) in discovery and validation phases, respectively. Further, concordance index of the nomogram was 0.81 and 0.77 in discovery and validation phases, respectively. Based on systematic review of published literatures, our model was superior to all existing models for early-stage LUAD. In summary, our trans-omics model may help physicians accurately identify patients with high mortality risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- DNA methylation
- early-stage
- gene expression
- lung adenocarcinoma
- prognostic prediction
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
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Aging
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Dong, Xuesi
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Zhang, Ruyang
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He, Jieyu
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Lai, Linjing
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Alolga, Raphael ...
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Shen, Sipeng
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visa fler...
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Zhu, Ying
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You, Dongfang
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Lin, Lijuan
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Chen, Chao
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Zhao, Yang
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Duan, Weiwei
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Su, Li
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Shafer, Andrea
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Salama, Moran
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Fleischer, Thoma ...
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Bjaanæs, Maria M ...
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Karlsson, Anna
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Planck, Maria
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Wang, Rui
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Staaf, Johan
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Helland, Åslaug
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Esteller, Manel
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Wei, Yongyue
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Chen, Feng
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Christiani, Davi ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Aging
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Lunds universitet