Genetic instability in the 9q22.3 region is a late event in the development of squamous cell carcinoma.

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Fältnamn	Indikatorer	Metadata
000		03144naa a2200397 4500
001		oai:DiVA.org:kth-197609
003		SwePub
008		161205s1998 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1976092 URI
024	7	a https://doi.org/10.1038/sj.onc.12020802 DOI
040		a (SwePub)kth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Ahmadian, Afshinu KTH,Genteknologi4 aut0 (Swepub:kth)u1kjb6gb
245	1 0	a Genetic instability in the 9q22.3 region is a late event in the development of squamous cell carcinoma.
264		c 1998-10-09
264	1	b Springer Science and Business Media LLC,c 1998
338		a print2 rdacarrier
500		a QCR 20161207
520		a Squamous cell carcinoma (SCC) of the skin represents a group of neoplasms which is associated with exposure to UV light. Recently, we obtained data suggesting that invasive skin cancer and its precursors derive from one original neoplastic clone. Here, the analysis were extended by loss of heterozygosity (LOH) analysis in the chromosome 9q22.3 region. A total of 85 samples, taken from twenty-two sections of sun-exposed sites, corresponding to normal epidermis, morphological normal cells with positive immuno-staining for the p53 protein (p53 patches), dysplasias, cancer in situ (CIS) and squamous cell carcinomas (SCC) of the skin were analysed. Overall, about 70% of p53 patches had mutations in the p53 gene but not LOH in the p53 gene or 9q22.3 region. Approximately 70% of the dysplasias showed p53 mutations of which about 40% had LOH in the p53 region but not in the 9q22.3 region. In contrast, about 65% of SCC and CIS displayed LOH in the 9q22.3 region, as well as frequent (80%) mutations and/or LOH in the p53 gene. These findings strongly suggest that alterations in the p53 gene is an early event in the progression towards SCC, whereas malignant development involves LOH and alterations in at least one (or several) tumor suppressor genes located in chromosome 9q22.3.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
700	1	a Ren, Z P4 aut
700	1	a Williams, Cecilia,d 1969-u KTH,Proteomik och nanobioteknologi4 aut0 (Swepub:kth)u1ygqmuy
700	1	a Pontén, F4 aut
700	1	a Odeberg, Jacobu KTH,Proteomik och nanobioteknologi4 aut0 (Swepub:kth)u1e4yljo
700	1	a Pontén, J4 aut
700	1	a Uhlén, Mathiasu KTH,Proteomik och nanobioteknologi4 aut0 (Swepub:kth)u1dulvmw
700	1	a Lundeberg, Joakimu KTH,Genteknologi4 aut0 (Swepub:kth)u1qkn9kw
710	2	a KTHb Genteknologi4 org
773	0	t Oncogened : Springer Science and Business Media LLCg 17:14q 17:14x 0950-9232x 1476-5594
856	4	u https://www.nature.com/articles/1202080.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-197609
856	4 8	u https://doi.org/10.1038/sj.onc.1202080

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Av författaren/redakt...: Ahmadian, Afshin; Ren, Z P; Williams, Cecili ...; Pontén, F; Odeberg, Jacob; Pontén, J; visa fler...; Uhlén, Mathias; Lundeberg, Joaki ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

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