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A combined proteomi...
A combined proteomics and mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer
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- Nounu, Aayah (författare)
- Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom,Univ Bristol, Bristol Med Sch, Med Res Council MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Sch Cellular & Mol Med, Bristol, Avon, England.
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- Greenhough, Alexander (författare)
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom; Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the West of England, Bristol, United Kingdom,Univ Bristol, Sch Cellular & Mol Med, Bristol, Avon, England.;Univ West England, Fac Hlth & Appl Sci, Ctr Res Biosci, Bristol, Avon, England.
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- Heesom, Kate J. (författare)
- Proteomics Facility, Faculty of Life Sciences, University of Bristol, Bristol, United Kingdom,Univ Bristol, Fac Life Sci, Prote Facil, Bristol, Avon, England.
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visa fler...
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- Richmond, Rebecca C. (författare)
- Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom,Univ Bristol, Bristol Med Sch, Med Res Council MRC Integrat Epidemiol Unit, Bristol, Avon, England.
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- Zheng, Jie (författare)
- Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom,Univ Bristol, Bristol Med Sch, Med Res Council MRC Integrat Epidemiol Unit, Bristol, Avon, England.
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- Weinstein, Stephanie J. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
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- Albanes, Demetrius (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
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- Baron, John A. (författare)
- Department of Medicine, University of North Carolina School of Medicine, NC, Chapel Hill, United States,Univ N Carolina, Dept Med, Sch Med, Chapel Hill, NC USA.
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- Hopper, John L. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Depart-ment of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea,Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.;Seoul Natl Univ, Sch Publ Hlth, Dept Epidemiol, Seoul, South Korea.;Seoul Natl Univ, Inst Hlth & Environm, Seoul, South Korea.,Univ Virginia, Dept Family Med, Charlottesville, VA USA.
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- Figueiredo, Jane C. (författare)
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States,Cedars Sinai Med Ctr, Dept Med, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA.;Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.
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- Newcomb, Polly A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.
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- Lindor, Noralane M. (författare)
- Department of Health Science Research, Mayo Clinic, AZ, Scottsdale, United States,Mayo Clin, Dept Hlth Sci Res, Scottsdale, AZ USA.
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- Casey, Graham (författare)
- Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States,Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
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- Platz, Elizabeth A. (författare)
- Department of Epidemiology, Johns Hopkins Bloom-berg School of Public Health, MD, Baltimore, United States,Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
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- Le Marchand, Loc (författare)
- University of Hawaii Cancer Center, HI, Honolulu, United States,Univ Hawaii Canc Ctr, Honolulu, HI USA.
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- Ulrich, Cornelia M. (författare)
- Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States,Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA.;Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.
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- Li, Christopher I. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.
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- van Duijnhoven, Franzel J.B. (författare)
- Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands,Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.
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- Gsur, Andrea (författare)
- Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria,Med Univ Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria.
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- Campbell, Peter T. (författare)
- Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States,Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA.
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- Moreno, Víctor (författare)
- Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain; CIBER Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain,Catalan Inst Oncol IDIBELL, Oncol Data Analyt Program, Barcelona, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;Univ Barcelona, Fac Med, Dept Clin Sci, Barcelona, Spain.;Bellvitge Biomed Res Inst IDIBELL, ONCOBEL Program, Barcelona, Spain.
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- Vodicka, Pavel (författare)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic,Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic.;Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague, Czech Republic.;Charles Univ Prague, Fac Med, Plzen, Czech Republic.;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.
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- Vodickova, Ludmila (författare)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic,Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic.;Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague, Czech Republic.;Charles Univ Prague, Fac Med, Plzen, Czech Republic.;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany,German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.
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- Chang-Claude, Jenny (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Uni-versity Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Canc Ctr Hamburg UCCH, Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany.
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- Hoffmeister, Michael (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany,German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
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- Sakoda, Lori C. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States,Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.;Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA.
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- Slattery, Martha L. (författare)
- Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States,Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA.
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- Schoen, Robert E. (författare)
- Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States,Univ Pittsburgh, Med Ctr, Dept Med & Epidemiol, Pittsburgh, PA USA.
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France,World Hlth Org, Nutr & Metab Sect, Int Agcy Res Canc, Lyon, France.
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- Castellví-Bel, Sergi (författare)
- Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain,Univ Barcelona, Hosp Clin, Gastroenterol Dept,Ctr Invest Biomed Red Enfermed, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
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- Kim, Hyeong Rok (författare)
- Depart-ment of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea,Chonnam Natl Univ, Dept Surg, Hwasun Hosp & Med Sch, Hwasun, South Korea.
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- Kweon, Sun-Seog (författare)
- Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea,Chonnam Natl Univ, Dept Prevent Med, Med Sch, Gwangju, South Korea.;Chonnam Natl Univ, Jeonnam Reg Canc Ctr, Hwasun Hosp, Hwasun, South Korea.
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- Chan, Andrew T. (författare)
- Divi-sion of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Broad Inst Harvard & Mit, Cambridge, MA USA.;Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Dept Immunol & Infect Dis, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
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- Li, Li (författare)
- Department of Family Medicine, University of Virginia, VA, Charlottesville, United States,Univ Bristol, Bristol Med Sch, Med Res Council MRC Integrat Epidemiol Unit, Bristol, Avon, England.
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- Zheng, Wei (författare)
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, TN, Nashville, United States,Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol,Dept Med,Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA.
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- Bishop, D. Timothy (författare)
- Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom,Univ Leeds, Leeds Inst Canc & Pathol, Leeds, W Yorkshire, England.
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- Buchanan, Daniel D. (författare)
- Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia,Univ Melbourne, Dept Clin Pathol, Colorectal Oncogen Grp, Parkville, Vic, Australia.;Univ Melbourne, Ctr Canc Res, Victorian Comprehens Canc Ctr, Parkville, Vic, Australia.;Royal Melbourne Hosp, Genet Med & Family Canc Clin, Parkville, Vic, Australia.
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- Giles, Graham G. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia,Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Monash Hlth, Precis Med, Clayton, Vic, Australia.
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- Gruber, Stephen B. (författare)
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States,Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.;Univ Southern Calif, Keck Sch Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90007 USA.
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- Rennert, Gad (författare)
- Depart-ment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel,Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, Haifa, Israel.;Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel.;Clalit Natl Canc Control Ctr, Haifa, Israel.
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- Stadler, Zsofia K. (författare)
- Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, New York, United States,Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
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- Harrison, Tabitha A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.
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- Lin, Yi (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.
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- Keku, Temitope O. (författare)
- Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States,Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC USA.
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- Woods, Michael O. (författare)
- Discipline of Genetics, Memorial University of Newfoundland, St. John’s, Canada,Mem Univ Newfoundland, Discipline Genet, St John, NF, Canada.
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- Schafmayer, Clemens (författare)
- Depart-ment of General Surgery, University Hospital Rostock, Rostock, Germany,Univ Hosp Rostock, Dept Gen Surg, Rostock, Germany.
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi,Umeå Univ, Dept Radiat Sci, Oncol Unit, Umeå, Sweden.;Umeå Univ, Wallenberg Ctr Mol Med, Umeå, Sweden.
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- Gallinger, Steven (författare)
- Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada,Univ Toronto, Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada.
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- Hampel, Heather (författare)
- Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, OH, Columbus, United States,Ohio State Univ, Dept Internal Med, Div Human Genet, Comprehens Canc Ctr, Columbus, OH 43210 USA.,Univ Southern Calif, Preventat Med, Los Angeles, CA 90007 USA.
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- Berndt, Sonja I. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
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- Pharoah, Paul D.P. (författare)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom,Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
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- Lindblom, Annika (författare)
- Karolinska Institutet
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- Wolk, Alicja (författare)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
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- Wu, Anna H. (författare)
- University of Southern California, Preventative Medicine, CA, Los Angeles, United States
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- White, Emily (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
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- Drew, David A. (författare)
- Massachusetts General Hospital, Harvard Medical School, Clinical and Translational Epidemiology Unit, MA, Boston, United States,Massachusetts Gen Hosp, Boston, MA 02114 USA.;Harvard Med Sch, Clin & Translat Epidemiol Unit, Boston, MA 02115 USA.
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- Scherer, Dominique (författare)
- Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany,Heidelberg Univ, Inst Med Biometry & Informat, Heidelberg, Germany.
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- Bermejo, Justo Lorenzo (författare)
- Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany,Heidelberg Univ, Inst Med Biometry & Informat, Heidelberg, Germany.
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- Williams, Ann C. (författare)
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom,Univ Bristol, Sch Cellular & Mol Med, Bristol, Avon, England.
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- Relton, Caroline L. (författare)
- Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom Univ Bristol, Bristol Med Sch, Med Res Council MRC Integrat Epidemiol Unit, Bristol, Avon, England;Univ Bristol, Sch Cellular & Mol Med, Bristol, Avon, England. (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : Elsevier. - 1055-9965 .- 1538-7755. ; 30:3, s. 564-575
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Evidence for aspirin’s chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of action is not well-understood. We combined a proteomic approach with Mendelian randomization (MR) to identify possible new aspirin targets that decrease CRC risk.Methods: Human colorectal adenoma cells (RG/C2) were treated with aspirin (24 hours) and a stable isotope labeling with amino acids in cell culture (SILAC) based proteomics approach identified altered protein expression. Protein quantitative trait loci (pQTLs) from INTERVAL (N ¼ 3,301) and expression QTLs (eQTLs) from the eQTLGen Consortium (N ¼ 31,684) were used as genetic proxies for protein and mRNA expression levels. Two-sample MR of mRNA/protein expression on CRC risk was performed using eQTL/pQTL data combined with CRC genetic summary data from the Colon Cancer Family Registry (CCFR), Colorectal Transdisciplinary (CORECT), Genetics and Epidemiology of Colorectal Cancer (GECCO) consortia and UK Biobank (55,168 cases and 65,160 controls).Results: Altered expression was detected for 125/5886 proteins. Of these, aspirin decreased MCM6, RRM2, and ARFIP2 expression, and MR analysis showed that a standard deviation increase in mRNA/protein expression was associated with increased CRC risk (OR: 1.08, 95% CI, 1.03–1.13; OR: 3.33, 95% CI, 2.46–4.50; and OR: 1.15, 95% CI, 1.02–1.29, respectively).Conclusions: MCM6 and RRM2 are involved in DNA repair whereby reduced expression may lead to increased DNA aberrations and ultimately cancer cell death, whereas ARFIP2 is involved in actin cytoskeletal regulation, indicating a possible role in aspirin’s reduction of metastasis.Impact: Our approach has shown how laboratory experiments and population-based approaches can combine to identify aspirin-targeted proteins possibly affecting CRC risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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Nounu, Aayah
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Greenhough, Alex ...
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Heesom, Kate J.
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Richmond, Rebecc ...
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Zheng, Jie
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Weinstein, Steph ...
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visa fler...
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Albanes, Demetri ...
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Baron, John A.
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Hopper, John L.
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Figueiredo, Jane ...
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Newcomb, Polly A ...
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Lindor, Noralane ...
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Casey, Graham
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Platz, Elizabeth ...
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Le Marchand, Loc
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Ulrich, Cornelia ...
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Li, Christopher ...
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van Duijnhoven, ...
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Gsur, Andrea
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Campbell, Peter ...
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Moreno, Víctor
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Vodicka, Pavel
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Vodickova, Ludmi ...
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Brenner, Hermann
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Chang-Claude, Je ...
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Hoffmeister, Mic ...
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Sakoda, Lori C.
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Slattery, Martha ...
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Schoen, Robert E ...
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Gunter, Marc J.
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Castellví-Bel, S ...
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Kim, Hyeong Rok
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Kweon, Sun-Seog
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Chan, Andrew T.
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Li, Li
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Zheng, Wei
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Bishop, D. Timot ...
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Buchanan, Daniel ...
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Giles, Graham G.
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Gruber, Stephen ...
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Rennert, Gad
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Stadler, Zsofia ...
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Harrison, Tabith ...
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Lin, Yi
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Keku, Temitope O ...
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Woods, Michael O ...
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Schafmayer, Clem ...
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van Guelpen, Bet ...
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Gallinger, Steve ...
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Hampel, Heather
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Berndt, Sonja I.
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Pharoah, Paul D. ...
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Lindblom, Annika
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Wolk, Alicja
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Wu, Anna H.
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White, Emily
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Peters, Ulrike
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Drew, David A.
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Scherer, Dominiq ...
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Bermejo, Justo L ...
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Williams, Ann C.
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Relton, Caroline ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Umeå universitet
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