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Hematopoietic loss ...
Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
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- Sano, Soichi (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.;Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan.
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- Horitani, Keita (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Ogawa, Hayato (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Halvardson, Jonatan, 1982- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Lars Forsberg
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- Chavkin, Nicholas W. (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.;Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Wang, Ying (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Sano, Miho (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Mattisson, Jonas (författare)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Lars Forsberg
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- Hata, Atsushi (författare)
- Chiba University Graduate School of Medicine, Department of General Thoracic Surgery, Chiba 260-8670, Japan.
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- Danielsson, Marcus (författare)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Lars Forsberg
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- Miura-Yura, Emiri (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Zaghlool, Ammar, 1980- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Lars Forsberg
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- Evans, Megan A. (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Fall, Tove, 1979- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- De Hoyos, Henry N. (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Sundström, Johan, Professor, 1971- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk epidemiologi
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- Yura, Yoshimitsu (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Kour, Anupreet (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Arai, Yohei (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Thel, Mark C. (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Arai, Yuka (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Mychaleckyj, Josyf C. (författare)
- Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
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- Hirschi, Karen K. (författare)
- Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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- Forsberg, Lars A., 1974- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,The Beijer Laboratory, Uppsala University, 75185 Uppsala, Sweden.,Lars Forsberg
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- Walsh, Kenneth (författare)
- Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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Hematovascular Biology Center, Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.;Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan. Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2022
- 2022
- Engelska.
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 377:6603, s. 292-297
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal and mechanistic relationships have yet to be established. Here, we show that male mice reconstituted with bone marrow cells lacking the Y chromosome display increased mortality and age-related profibrotic pathologies including reduced cardiac function. Cardiac macrophages lacking the Y chromosome exhibited polarization toward a more fibrotic phenotype, and treatment with a transforming growth factor β1–neutralizing antibody ameliorated cardiac dysfunction in mLOY mice. A prospective study revealed that mLOY in blood is associated with an increased risk for cardiovascular disease and heart failure–associated mortality. Together, these results indicate that hematopoietic mLOY causally contributes to fibrosis, cardiac dysfunction, and mortality in men.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Epidemiology
- Epidemiologi
- Kardiologi
- Cardiology
- Medical Genetics
- Medicinsk genetik
- Immunologi
- Immunology
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Sano, Soichi
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Horitani, Keita
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Ogawa, Hayato
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Halvardson, Jona ...
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Chavkin, Nichola ...
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Wang, Ying
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Sano, Miho
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Mattisson, Jonas
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Hata, Atsushi
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Danielsson, Marc ...
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Miura-Yura, Emir ...
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Zaghlool, Ammar, ...
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Evans, Megan A.
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Fall, Tove, 1979 ...
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De Hoyos, Henry ...
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Sundström, Johan ...
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Yura, Yoshimitsu
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Kour, Anupreet
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Arai, Yohei
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Thel, Mark C.
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Arai, Yuka
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Mychaleckyj, Jos ...
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Hirschi, Karen K ...
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Forsberg, Lars A ...
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Walsh, Kenneth
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