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WFRF:(Zhao Xian)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003505naa a2200433 4500
001oai:gup.ub.gu.se/335205
003SwePub
008240528s2024 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3352052 URI
0247 a https://doi.org/10.1007/s12035-024-03965-42 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gao, Qi4 aut
2451 0a The Association Between Branched-Chain Amino Acid Concentrations and the Risk of Autism Spectrum Disorder in Preschool-Aged Children
264 1c 2024
520 a Several studies have linked branched-chain amino acid (BCAA) metabolism disorders with autism spectrum disorder (ASD), but the results have been inconsistent. The purpose of this study was to explore the association between BCAA concentrations and the risk of ASD. A total of 313 participants were recruited from two tertiary referral hospitals from May 2018 to July 2021. Concentrations of BCAAs in dried blood spots were analyzed using liquid chromatography-tandem mass spectrometry-based analysis. Multivariate analyses and restricted cubic spline models were used to identify the association between BCAAs and the risk of ASD, and a nomogram was developed by using multivariate logistic regression and the risk was determined by receiver operating characteristic curve analysis and calibration curve analysis. Concentrations of total BCAA, valine, and leucine/isoleucine were higher in the ASD group, and all of them were positively and non-linearly associated with the risk of ASD even after adjusting for potential confounding factors such as age, gender, body mass index, and concentrations of BCAAs (P < 0.05). The nomogram integrating total BCAA and valine showed a good discriminant AUC value of 0.756 (95% CI 0.676-0.835). The model could yield net benefits across a reasonable range of risk thresholds. In the stratified analysis, the diagnostic ability of the model was more pronounced in children older than 3 years. We provide evidence that increased levels of BCAAs are associated with the risk of ASD, and the nomogram model of BCAAs presented here can serve as a marker for the early diagnosis of ASD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Branched-chain amino acids
653 a Autism spectrum disorders
653 a Nomogram
653 a Early diagnosis
653 a Preschool children
7001 a Bi, Dan4 aut
7001 a Li, Bingbing4 aut
7001 a Ni, Min4 aut
7001 a Pang, Dizhou4 aut
7001 a Li, Xian4 aut
7001 a Zhang, Xiaoli4 aut
7001 a Xu, Yiran4 aut
7001 a Zhao, Qiang4 aut
7001 a Zhu, Changlian,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation4 aut0 (Swepub:gu)xzhuch
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering4 org
7730 t MOLECULAR NEUROBIOLOGYx 0893-7648x 1559-1182
8564 8u https://gup.ub.gu.se/publication/335205
8564 8u https://doi.org/10.1007/s12035-024-03965-4

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