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High levels of (un)...
High levels of (un)switched memory B cells are associated with better outcome in patients with advanced atherosclerotic disease
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- Meeuwsen, John A.L. (författare)
- University Medical Center Utrecht
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- van Duijvenvoorde, Amerik (författare)
- University Medical Center Utrecht
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- Gohar, Aisha (författare)
- University Medical Center Utrecht
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- Kozma, Maria O. (författare)
- Medical University of Vienna
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- van de Weg, Sander M. (författare)
- University Medical Center Utrecht
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- Gijsberts, Crystel M (författare)
- University Medical Center Utrecht
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- Haitjema, Saskia (författare)
- University Medical Center Utrecht
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- Björkbacka, Harry (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups,Skåne University Hospital
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- Fredrikson, Gunilla N. (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital
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- de Borst, Gert J. (författare)
- University Medical Center Utrecht
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- den Ruijter, Hester M (författare)
- University Medical Center Utrecht
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- Pasterkamp, Gerard (författare)
- University Medical Center Utrecht
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- Binder, Christoph J. (författare)
- Medical University of Vienna
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- Hoefer, Imo E (författare)
- University Medical Center Utrecht
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- de Jager, Saskia C A (författare)
- University Medical Center Utrecht
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 6:9
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background--Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B-cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating B-cell subtypes with the occurrence of secondary cardiovascular events in advanced atherosclerotic disease. Methods and Results--This cohort study consists of 168 patients who were included in the Athero-Express biobank between 2009 and 2011. Before surgery, peripheral blood mononuclear cells were isolated and stored in liquid nitrogen. After gentle thawing of the peripheral blood mononuclear cells, different B-cell subtypes including naïve, (un)switched memory, and CD27+CD43+ B1-like B cells, were analyzed by flow cytometry. Univariable and multivariable Cox proportional hazard models were used to analyze associations between B-cell subtypes, circulating antibodies and secondary cardiovascular manifestations during the 3-year follow-up period. Mean age was 70.1±9.6 years, males represented 62.8% of the population, and 54 patients had secondary manifestations during follow-up. High numbers of unswitched memory cells were protective against secondary outcome (hazard ratio, 0.30 [95% CI, 0.13-0.69]; P < 0.01). Similar results were obtained for the switched memory cells that also showed to be protective against secondary outcome (hazard ratio, 0.33 [95% CI, 0.14-0.77]; P = 0.01). Conclusions--A high number of (un)switched memory B cells is associated with better outcome following carotid artery endarterectomy. These findings suggest a potential role for B-cell subsets in prediction and prevention of secondary cardiovascular events in patients with atherosclerosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Atherosclerosis
- B lymphocytes
- Carotid endarterectomy
- Recurrent event
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- art (ämneskategori)
- ref (ämneskategori)
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Meeuwsen, John A ...
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van Duijvenvoord ...
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Gohar, Aisha
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Kozma, Maria O.
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van de Weg, Sand ...
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Gijsberts, Cryst ...
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visa fler...
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Haitjema, Saskia
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Björkbacka, Harr ...
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Fredrikson, Guni ...
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de Borst, Gert J ...
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den Ruijter, Hes ...
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Pasterkamp, Gera ...
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Binder, Christop ...
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Hoefer, Imo E
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de Jager, Saskia ...
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Lunds universitet