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Sökning: WFRF:(van der Schouw Yvonne T.) > (2020-2024) > Age at menopause an...

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FältnamnIndikatorerMetadata
00012771naa a2200865 4500
001oai:DiVA.org:umu-214773
003SwePub
008231009s2023 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:ba278b27-371f-400f-a562-eace75e61842
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2147732 URI
0247 a https://doi.org/10.1161/JAHA.123.0302802 DOI
0247 a https://lup.lub.lu.se/record/ba278b27-371f-400f-a562-eace75e618422 URI
040 a (SwePub)umud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tschiderer, Lenau Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria4 aut
2451 0a Age at menopause and the risk of stroke :b observational and mendelian randomization analysis in 204 244 postmenopausal women
264 1b American Heart Association Inc.c 2023
338 a electronic2 rdacarrier
520 a BACKGROUND: Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear.METHODS AND RESULTS: We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases) study. A total of 204 244 postmenopausal women without a history of stroke at baseline were included (7883 from EPIC-CVD [5292 from the subcohort], 196 361 from the UK Biobank). Pooled mean baseline age was 58.9 years (SD, 5.8), and pooled mean age at menopause was 47.8 years (SD, 6.2). Over a median follow-up of 12.6 years (interquartile range, 11.8–13.3), 6770 women experienced a stroke (5155 ischemic strokes, 1615 hemorrhagic strokes, 976 intracerebral hemorrhages, and 639 subarachnoid hemorrhages). In multivariable adjusted observational Cox regression analyses, the pooled hazard ratios per 5 years younger age at menopause were 1.09 (95% CI, 1.07–1.12) for stroke, 1.09 (95% CI, 1.06–1.13) for ischemic stroke, 1.10 (95% CI, 1.04–1.16) for hemorrhagic stroke, 1.14 (95% CI, 1.08–1.20) for intracerebral hemorrhage, and 1.00 (95% CI, 0.84–1.20) for subarachnoid hemorrhage. When using 2-sample Mendelian randomization analysis, we found no statistically significant association between genetically proxied age at menopause and risk of any type of stroke.CONCLUSIONS: In our study, earlier age at menopause was related to a higher risk of stroke. We found no statistically significant association between genetically proxied age at menopause and risk of stroke, suggesting no causal relationship.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653 a age at menopause
653 a Mendelian randomization analysis
653 a observational analysis
653 a stroke
653 a age at menopause
653 a Mendelian randomization analysis
653 a observational analysis
653 a stroke
7001 a Peters, Sanne A. E.u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; The George Institute for Global Health, School of Public Health, Imperial College London, London, United Kingdom; The George Institute for Global Health, University of New South Wales, NSW, Sydney, Australia4 aut
7001 a van der Schouw, Yvonne T.u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands4 aut
7001 a van Westing, Anniek C.u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands4 aut
7001 a Tong, Tammy Y. N.u Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut
7001 a Willeit, Peteru Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom4 aut
7001 a Seekircher, Lisau Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria4 aut
7001 a Moreno-Iribas, Conchiu Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Huerta, José Maríau Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council-IMIB, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Crous-Bou, Martau Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)– Bellvitge Biomedical Research Institute, (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard University4 aut
7001 a Söderholm, Martinu Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-ms8
7001 a Schulze, Matthias B.u Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany4 aut
7001 a Johansson, Ceciliau Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)cejo0008
7001 a Själander, Sara,d 1981-u Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)saamer01
7001 a Heath, Alicia K.u SwedenDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut
7001 a Macciotta, Alessandrau Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Turin, Italy4 aut
7001 a Dahm, Christina C.u Department of Public Health, Aarhus University, Aarhus, Denmark4 aut
7001 a Ibsen, Daniel B.u Department of Public Health, Aarhus University, Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus, Denmark; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark4 aut
7001 a Pala, Valeriau Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy4 aut
7001 a Mellemkjær, Leneu Danish Cancer Society Research Center, Copenhagen, Denmark4 aut
7001 a Burgess, Stephenu Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom,Medical Research Council Biostatistics Unit4 aut
7001 a Wood, Angelau Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom4 aut
7001 a Kaaks, Rudolfu Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany4 aut
7001 a Katzke, Verenau Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany4 aut
7001 a Amiano, Pilaru Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastian, Spain,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Rodriguez-Barranco, Miguelu Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)4 aut
7001 a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen
7001 a Weiderpass, Elisabeteu International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut
7001 a Tjønneland, Anneu Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Section of Environmental Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Halkjær, Jytteu Danish Cancer Society Research Center, Copenhagen, Denmark4 aut
7001 a Panico, Salvatoreu School of Medicine, Federico II University, Naples, Italy4 aut
7001 a Danesh, Johnu BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health and Care Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge, United Kingdom; The National Institute for Health and Care Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; Human Genetics, Wellcome Sanger Institute, Saffron Walden, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom,Wellcome Trust Sanger Institute,Cambridge University Hospitals NHS Foundation Trust4 aut
7001 a Butterworth, Adamu Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, United Kingdom; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom4 aut
7001 a Onland-Moret, N. Charlotteu Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands4 aut
7102 a Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austriab Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; The George Institute for Global Health, School of Public Health, Imperial College London, London, United Kingdom; The George Institute for Global Health, University of New South Wales, NSW, Sydney, Australia4 org
7730 t Journal of the American Heart Associationd : American Heart Association Inc.g 12:18q 12:18x 2047-9980
8564 u https://doi.org/10.1161/JAHA.123.030280y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1803336/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1161/JAHA.123.030280x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214773
8564 8u https://doi.org/10.1161/JAHA.123.030280
8564 8u https://lup.lub.lu.se/record/ba278b27-371f-400f-a562-eace75e61842

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