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Sökning: L773:0022 1767 > (1977-1979) > Expression of prote...

Expression of protein HC on the plasma membrane of different human cell types

Pearlstein, E (författare)
Turesson, I (författare)
Lund University,Lunds universitet,Myelomgruppen,Forskargrupper vid Lunds universitet,Myeloma research group,Lund University Research Groups
Tejler, L (författare)
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Grubb, A O (författare)
Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups
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 (creator_code:org_t)
1977
1977
Engelska.
Ingår i: Journal of immunology. - 0022-1767. ; 119:3, s. 9-824
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The surface expression of a recently described plasma glycoprotein called human complex-forming glycoprotein, hetergeneous in charge (protein HC) on a number of different human cell types was investigated. By means of direct and indirect immunofluorescence, protein HC was shown to be associated with the surface of virtually all cells of the investigated normal cell types including erythrocytes, peripheral blood B and T lymphocytes, and the human fibroblast lines HE 81, HE 31, and WI 38. When transformed and malignant cell populations were studied, it was found that some populations (e.g., the T cell line Molt-4) carried protein HC on the surfaces of very few cells, whereas other cell populations (e.g., chronic lymphocytic leukemia lymphocytes) carried the protein on most cells. Malignant cell populations with intermediary percentages of protein HC-positive cells were also found. Protein HC on the cell surface of normal peripheral blood lymphocytes could be redistributed by incubation of the cells with anti-protein HC-antiserum at 37 degrees C, and this reaction could be inhibited by sodium azide.

Nyckelord

Animals
B-Lymphocytes/immunology
Cell Line
Cell Membrane/immunology
Erythrocytes/immunology
Fibroblasts/immunology
Fluorescent Antibody Technique
Glycoproteins/immunology
Humans
Leukemia, Lymphoid/immunology
Lymphocytes/immunology
Rabbits
T-Lymphocytes/immunology

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Pearlstein, E
Turesson, I
Tejler, L
Grubb, A O
Artiklar i publikationen
Journal of immun ...
Av lärosätet
Lunds universitet

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