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The XBI BioLab for ...
The XBI BioLab for life science experiments at the European XFEL
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- Han, Huijong (author)
- European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany; Univ Oulu, Bioctr Oulu, Aapistie 7, Oulu 90220, Finland; Univ Oulu, Fac Biochem & Mol Med, Aapistie 7, Oulu 90220, Finland
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- Round, Ekaterina (author)
- European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
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- Schubert, Robin (author)
- European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany; Univ Hamburg, DESY, Lab Struct Biol Infect & Inflammat, Inst Biochem & Mol Biol, Bldg 22a, Notkestr 85, D-22603 Hamburg, Germany; Hamburg Ctr Ultrafast Imaging CUI, Luruper Chaussee 149, D-22761 Hamburg, Germany
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- Gül, Yasmin (author)
- European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
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- Makroczyová, Jana (author)
- European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany; Slovak Acad Sci, Inst Mol Biol, Dubravska Cesta 21, Bratislava 84551, Slovakia
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- Meza, Domingo (author)
- Arizona State Univ, Biodesign Ctr Appl Struct Discovery, Tempe, AZ USA; Arizona State Univ, Sch Mol Sci, Tempe, AZ USA
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- Heuser, Philipp (author)
- European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
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- Aepfelbacher, Martin (author)
- Univ Med Ctr Hamburg Eppendorf, Inst Med Microbiol Virol & Hyg, Martinistr 52, D-20246 Hamburg, Germany
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- Barák, Imrich (author)
- Slovak Acad Sci, Inst Mol Biol, Dubravska Cesta 21, Bratislava 84551, Slovakia
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- Betzel, Christian (author)
- Univ Hamburg, DESY, Lab Struct Biol Infect & Inflammat, Inst Biochem & Mol Biol, Bldg 22a, Notkestr 85, D-22603 Hamburg, Germany; Hamburg Ctr Ultrafast Imaging CUI, Luruper Chaussee 149, D-22761 Hamburg, Germany
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- Fromme, Petra (author)
- Arizona State Univ, Biodesign Ctr Appl Struct Discovery, Tempe, AZ USA; Arizona State Univ, Sch Mol Sci, Tempe, AZ USA
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- Kursula, Inari (author)
- Univ Oulu, Bioctr Oulu, Aapistie 7, Oulu 90220, Finland; Univ Oulu, Fac Biochem & Mol Med, Aapistie 7, Oulu 90220, Finland; Univ Bergen, Dept Biomed, Jonas Lies Vei 91, N-5009 Bergen, Norway
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- Nissen, Poul (author)
- Aarhus Univ, Dept Mol Biol & Genet, Nordic EMBL Partnership Mol Med, DANDRITE, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
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- Tereschenko, Elena (author)
- Russian Acad Sci, Inst Crystallog, 59 Leninsky Prospekt, Moscow 117333, Russia
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- Schulz, Joachim (author)
- European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany
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- Uetrecht, Charlotte (author)
- European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany; Leibniz Inst Expt Virol, Heinrich Pette Inst, Martinistr 52, D-20251 Hamburg, Germany
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- Ulicný, Jozef (author)
- Safarik Univ, Fac Sci, Inst Phys, Dept Biophys, Jesenna 5, Kosice 04154, Slovakia
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- Wilmanns, Matthias (author)
- European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
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- Hajdu, Janos (author)
- Uppsala universitet,Molekylär biofysik,Acad Sci Czech Republ, Inst Phys, European Extreme Light Infrastruct, Za Radnici 835, Dolni Brezany 25241, Czech Republic
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- Lamzin, Victor S. (author)
- European Mol Biol Lab, Notkestr 85, D-22607 Hamburg, Germany
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- Lorenzen, Kristina (author)
- European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany
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(creator_code:org_t)
- 2021
- 2021
- English.
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In: Journal of applied crystallography. - 0021-8898 .- 1600-5767. ; 54, s. 7-21
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Abstract
Subject headings
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- The science of X-ray free-electron lasers (XFELs) critically depends on the performance of the X-ray laser and on the quality of the samples placed into the X-ray beam. The stability of biological samples is limited and key biomolecular transformations occur on short timescales. Experiments in biology require a support laboratory in the immediate vicinity of the beamlines. The XBI BioLab of the European XFEL (XBI denotes XFEL Biology Infrastructure) is an integrated user facility connected to the beamlines for supporting a wide range of biological experiments. The laboratory was financed and built by a collaboration between the European XFEL and the XBI User Consortium, whose members come from Finland, Germany, the Slovak Republic, Sweden and the USA, with observers from Denmark and the Russian Federation. Arranged around a central wet laboratory, the XBI BioLab provides facilities for sample preparation and scoring, laboratories for growing prokaryotic and eukaryotic cells, a Bio Safety Level 2 laboratory, sample purification and characterization facilities, a crystallization laboratory, an anaerobic laboratory, an aerosol laboratory, a vacuum laboratory for injector tests, and laboratories for optical microscopy, atomic force microscopy and electron microscopy. Here, an overview of the XBI facility is given and some of the results of the first user experiments are highlighted.
Subject headings
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Keyword
- free-electron lasers (XFELs)
- European XFEL (EuXFEL)
- XBI Laboratory
- serial femtosecond crystallography (SFX)
- single-particle imaging (SPI)
- coherent diffractive imaging (CDI)
- time-resolved experiments
- structural biology
- sample preparation and characterization
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Han, Huijong
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Round, Ekaterina
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Schubert, Robin
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Gül, Yasmin
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Makroczyová, Jan ...
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Meza, Domingo
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show more...
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Heuser, Philipp
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Aepfelbacher, Ma ...
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Barák, Imrich
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Betzel, Christia ...
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Fromme, Petra
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Kursula, Inari
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Nissen, Poul
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Tereschenko, Ele ...
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Schulz, Joachim
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Uetrecht, Charlo ...
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Ulicný, Jozef
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Wilmanns, Matthi ...
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Hajdu, Janos
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Lamzin, Victor S ...
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Lorenzen, Kristi ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Other Physics To ...
- Articles in the publication
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Journal of appli ...
- By the university
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Uppsala University