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Sökning: WFRF:(Knol Edward F) > (2020-2023) > Eosinophils—from cr...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004832naa a2200589 4500
001oai:lup.lub.lu.se:4393ebc1-24c7-4e83-b113-0271bae316b8
003SwePub
008231222s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/4393ebc1-24c7-4e83-b113-0271bae316b82 URI
0247 a https://doi.org/10.1111/all.158842 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Jesenak, Milosu University Hospital Martin4 aut
2451 0a Eosinophils—from cradle to grave
264 1c 2023
300 a 26 s.
520 a Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be classified into primary (clonal) and secondary (reactive) disorders and idiopathic (hyper)eosinophilic syndromes. Depending on the biological specimen, the eosinophil count in different body compartments may serve as a biomarker reflecting the underlying pathophysiology and/or activity of distinct diseases and as a therapy-driving (predictive) and monitoring tool. Personalized selection of an appropriate therapeutic strategy directly or indirectly targeting the increased number and/or activity of eosinophils should be based on the understanding of eosinophil homeostasis including their interactions with other immune and non-immune cells within different body compartments. Hence, restoring as well as maintaining homeostasis within an individual's eosinophil pool is a goal of both specific and non-specific eosinophil-targeting therapies. Despite the overall favourable safety profile of the currently available anti-eosinophil biologics, the effect of eosinophil depletion should be monitored from the perspective of possible unwanted consequences.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a allergic diseases
653 a biologics
653 a biomarker
653 a COVID-19
653 a eosinophils
653 a non-allergic diseases
7001 a Diamant, Zuzanau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-zdt
7001 a Simon, Dagmaru Bern University Hospital4 aut
7001 a Tufvesson, Ellenu Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Tornbladinstitutet,Lungfysiologi och biomarkörer,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,Tornblad Institute,Lung physiology and biomarkers4 aut0 (Swepub:lu)medk-etu
7001 a Seys, Sven F.u Catholic University of Leuven4 aut
7001 a Mukherjee, Manaliu McMaster University4 aut
7001 a Lacy, Paigeu University of Alberta4 aut
7001 a Vijverberg, Susanneu University of Amsterdam4 aut
7001 a Slisz, Tomasu Charles University in Prague4 aut
7001 a Sediva, Annau University Hospital Motol4 aut
7001 a Simon, Hans Uweu University of Bern4 aut
7001 a Striz, Iljau Institute for Clinical and Experimental Medicine (IKEM)4 aut
7001 a Plevkova, Janau Comenius University4 aut
7001 a Schwarze, Jurgenu University of Edinburgh4 aut
7001 a Kosturiak, Radovanu Comenius University4 aut
7001 a Alexis, Neil E.u University of North Carolina4 aut
7001 a Untersmayr, Evau Medical University of Vienna4 aut
7001 a Vasakova, Martina Koziaru Charles University in Prague4 aut
7001 a Knol, Edwardu University Medical Center Utrecht4 aut
7001 a Koenderman, Leou University Medical Center Utrecht4 aut
7102 a University Hospital Martinb Institutionen för kliniska vetenskaper, Lund4 org
7730 t Allergy: European Journal of Allergy and Clinical Immunologyg 78:12, s. 3077-3102q 78:12<3077-3102x 0105-4538
8564 u http://dx.doi.org/10.1111/all.15884y FULLTEXT
8564 8u https://lup.lub.lu.se/record/4393ebc1-24c7-4e83-b113-0271bae316b8
8564 8u https://doi.org/10.1111/all.15884

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