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Sökning: WFRF:(Männistö Ville) > (2021) > Serum aromatic and ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004630naa a2200529 4500
001oai:lup.lub.lu.se:eebf59c1-4526-4298-81e3-e07e1379f749
003SwePub
008210111s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/eebf59c1-4526-4298-81e3-e07e1379f7492 URI
0247 a https://doi.org/10.1111/liv.147432 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a de Mello, Vanessa D.u University of Eastern Finland4 aut
2451 0a Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids
264 c 2020-12-05
264 1b Wiley,c 2021
520 a Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has been associated with multiple metabolic abnormalities. By applying a non-targeted metabolomics approach, we aimed at investigating whether serum metabolite profile that associates with NAFLD would differ in its association with NAFLD-related metabolic risk factors. Methods & Results: A total of 233 subjects (mean ± SD: 48.3 ± 9.3 years old; BMI: 43.1 ± 5.4 kg/m2; 64 male) undergoing bariatric surgery were studied. Of these participants, 164 with liver histology could be classified as normal liver (n = 79), simple steatosis (SS, n = 40) or non-alcoholic steatohepatitis (NASH, n = 45). Among the identified fasting serum metabolites with higher levels in those with NASH when compared to those with normal phenotype were the aromatic amino acids (AAAs: tryptophan, tyrosine and phenylalanine), the branched-chain amino acids (BCAAs: leucine and isoleucine), a phosphatidylcholine (PC(16:0/16:1)) and uridine (all FDRp < 0.05). Only tryptophan was significantly higher in those with NASH compared to those with SS (FDRp < 0.05). Only the AAAs tryptophan and tyrosine correlated positively with serum total and LDL cholesterol (FDRp < 0.1), and accordingly, with liver LDLR at mRNA expression level. In addition, tryptophan was the single AA associated with liver DNA methylation of CpG sites known to be differentially methylated in those with NASH. Conclusions: We found that serum levels of the NASH-related AAAs and BCAAs demonstrate divergent associations with serum lipids. The specific correlation of tryptophan with LDL-c may result from the molecular events affecting LDLR mRNA expression and NASH-associated methylation of genes in the liver.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a aromatic amino acids
653 a DNA methylation
653 a epigenetics
653 a LDL cholesterol
653 a NAFLD
653 a NASH
653 a non-targeted metabolomics
653 a tryptophan
7001 a Sehgal, Ratikau University of Eastern Finland4 aut
7001 a Männistö, Villeu University of Eastern Finland4 aut
7001 a Klåvus, Antonu University of Eastern Finland4 aut
7001 a Nilsson, Emma Au Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)endo-eca
7001 a Perfilyev, Alexanderu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)med-apy
7001 a Kaminska, Dorotau University of Eastern Finland4 aut
7001 a Miao, Zongu University of California, Los Angeles4 aut
7001 a Pajukanta, Päiviu University of California, Los Angeles4 aut
7001 a Ling, Charlotteu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)endo-cl0
7001 a Hanhineva, Katiu University of Eastern Finland,University of Turku4 aut
7001 a Pihlajamäki, Jussiu University of Eastern Finland,Kuopio University Hospital4 aut
7102 a University of Eastern Finlandb Diabetes - epigenetik4 org
7730 t Liver Internationald : Wileyg 41:4, s. 754-763q 41:4<754-763x 1478-3223x 1478-3231
8564 u http://dx.doi.org/10.1111/liv.14743x freey FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.14743
8564 8u https://lup.lub.lu.se/record/eebf59c1-4526-4298-81e3-e07e1379f749
8564 8u https://doi.org/10.1111/liv.14743

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