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A local subset of m...
A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation
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- Vallecillo-Garcia, Pedro (author)
- Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany.
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- Orgeur, Mickael (author)
- Univ Paris Cite, Inst Pasteur, CNRS, Unit Integrated Mycobacterial Pathogen,UMR 6047, F-75015 Paris, France.
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- Comai, Glenda (author)
- Inst Pasteur, CNRS, UMR 3738, Stem Cells & Dev Unit, Paris, France.
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- Poehle-Kronnawitter, Sophie (author)
- Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany.
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- Fischer, Cornelius (author)
- Berlin Inst Hlth Charite, Core Facil Genom, D-10178 Berlin, Germany.;Helmholtz Assoc, Max Delbruck Ctr Mol Med, D-10115 Berlin, Germany.
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- Gloger, Marleen (author)
- Uppsala universitet,Vaskulärbiologi,Max Delbruck Ctr Mol Med, Dept Translat Tumor Immunol, D-13125 Berlin, Germany.
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- Dumas, Camille E. (author)
- Aix Marseille Univ, IBDM, CNRS, UMR 7288, F-13009 Marseille, France.
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- Giesecke-Thiel, Claudia (author)
- Max Planck Inst Mol Genet, D-14195 Berlin, Germany.
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- Sauer, Sascha (author)
- Berlin Inst Hlth Charite, Core Facil Genom, D-10178 Berlin, Germany.;Helmholtz Assoc, Max Delbruck Ctr Mol Med, D-10115 Berlin, Germany.
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- Tajbakhsh, Shahragim (author)
- Inst Pasteur, CNRS, UMR 3738, Stem Cells & Dev Unit, Paris, France.
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- Hopken, Uta E. (author)
- Max Delbruck Ctr Mol Med, Dept Microenvironm Regulat Autoimmun & Canc, D-13125 Berlin, Germany.
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- Stricker, Sigmar (author)
- Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany.
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Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany Univ Paris Cite, Inst Pasteur, CNRS, Unit Integrated Mycobacterial Pathogen,UMR 6047, F-75015 Paris, France. (creator_code:org_t)
- Cell Press, 2023
- 2023
- English.
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In: Immunity. - : Cell Press. - 1074-7613 .- 1097-4180. ; 56:6, s. 1204-
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- During development, lymph node (LN) initiation is coordinated by lymphoid tissue organizer (LTo) cells that attract lymphoid tissue inducer (LTi) cells at strategic positions within the embryo. The identity and function of LTo cells during the initial attraction of LTi cells remain poorly understood. Using lineage tracing, we demon-strated that a subset of Osr1-expressing cells was mesenchymal LTo progenitors. By investigating the het-erogeneity of Osr1+ cells, we uncovered distinct mesenchymal LTo signatures at diverse anatomical loca-tions, identifying a common progenitor of mesenchymal LTos and LN-associated adipose tissue. Osr1 was essential for LN initiation, driving the commitment of mesenchymal LTo cells independent of neural ret-inoic acid, and for LN-associated lymphatic vasculature assembly. The combined action of chemokines CXCL13 and CCL21 was required for LN initiation. Our results redefine the role and identity of mesenchymal organizer cells and unify current views by proposing a model of cooperative cell function in LN initiation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
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Immunity
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Vallecillo-Garci ...
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Orgeur, Mickael
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Comai, Glenda
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Poehle-Kronnawit ...
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Fischer, Corneli ...
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Gloger, Marleen
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Dumas, Camille E ...
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Giesecke-Thiel, ...
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Sauer, Sascha
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Tajbakhsh, Shahr ...
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Hopken, Uta E.
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Stricker, Sigmar
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Developmental Bi ...
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Immunity
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Uppsala University