Sökning: WFRF:(Nieuwdorp Max) > (2020-2023) > Donor fecal microbi...
Fältnamn | Indikatorer | Metadata |
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000 | 03478naa a2200421 4500 | |
001 | oai:gup.ub.gu.se/296463 | |
003 | SwePub | |
008 | 240528s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2964632 URI |
024 | 7 | a https://doi.org/10.1126/scitranslmed.aaz89262 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a van Lier, Y. F.4 aut |
245 | 1 0 | a Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients |
264 | 1 | b American Association for the Advancement of Science (AAAS),c 2020 |
520 | a Disruption of the intestinal microbiota occurs frequently in allogeneic hematopoietic cell transplantation (allo-HCT) recipients and predisposes them to development of graft-versus-host disease (GvHD). In a prospective, single-center, single-arm study, we investigated the effect of donor fecal microbiota transplantation (FMT) on symptoms of steroid-refractory or steroid-dependent, acute or late-onset acute intestinal GvHD in 15 individuals who had undergone allo-HCT. Study participants received a fecal suspension from an unrelated healthy donor via nasoduodenal infusion. Donor FMT was well tolerated, and infection-related adverse events did not seem to be related to the FMT procedure. In 10 of 15 study participants, a complete clinical response was observed within 1 month after FMT, without additional interventions to alleviate GvHD symptoms. This response was accompanied by an increase in gut microbial a-diversity, a partial engraft-ment of donor bacterial species, and increased abundance of butyrate-producing bacteria, including Clostridiales and Blautia species. In 6 of the 10 responding donor FMT recipients, immunosuppressant drug therapy was successfully tapered. Durable remission of steroid-refractory or steroid-dependent GvHD after donor FMT was associated with improved survival at 24 weeks after donor FMT. This study highlights the potential of donor FMT as a treatment for steroid-refractory or steroid-dependent GvHD, but larger clinical trials are needed to confirm the safety and efficacy of this procedure. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
700 | 1 | a Davids, M.4 aut |
700 | 1 | a Haverkate, N. J. E.4 aut |
700 | 1 | a de Groot, P. F.4 aut |
700 | 1 | a Donker, M. L.4 aut |
700 | 1 | a Meijer, E.4 aut |
700 | 1 | a Heubel-Moenen, Fcji4 aut |
700 | 1 | a Nur, E.4 aut |
700 | 1 | a Zeerleder, S. S.4 aut |
700 | 1 | a Nieuwdorp, Maxu Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xnieum |
700 | 1 | a Blom, B.4 aut |
700 | 1 | a Hazenberg, M. D.4 aut |
710 | 2 | a Göteborgs universitetb Wallenberglaboratoriet4 org |
773 | 0 | t Science Translational Medicined : American Association for the Advancement of Science (AAAS)g 12:556q 12:556x 1946-6234x 1946-6242 |
856 | 4 8 | u https://gup.ub.gu.se/publication/296463 |
856 | 4 8 | u https://doi.org/10.1126/scitranslmed.aaz8926 |
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