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Sökning: WFRF:(Nieuwdorp Max) > (2020-2023) > Donor fecal microbi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003478naa a2200421 4500
001oai:gup.ub.gu.se/296463
003SwePub
008240528s2020 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2964632 URI
0247 a https://doi.org/10.1126/scitranslmed.aaz89262 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a van Lier, Y. F.4 aut
2451 0a Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients
264 1b American Association for the Advancement of Science (AAAS),c 2020
520 a Disruption of the intestinal microbiota occurs frequently in allogeneic hematopoietic cell transplantation (allo-HCT) recipients and predisposes them to development of graft-versus-host disease (GvHD). In a prospective, single-center, single-arm study, we investigated the effect of donor fecal microbiota transplantation (FMT) on symptoms of steroid-refractory or steroid-dependent, acute or late-onset acute intestinal GvHD in 15 individuals who had undergone allo-HCT. Study participants received a fecal suspension from an unrelated healthy donor via nasoduodenal infusion. Donor FMT was well tolerated, and infection-related adverse events did not seem to be related to the FMT procedure. In 10 of 15 study participants, a complete clinical response was observed within 1 month after FMT, without additional interventions to alleviate GvHD symptoms. This response was accompanied by an increase in gut microbial a-diversity, a partial engraft-ment of donor bacterial species, and increased abundance of butyrate-producing bacteria, including Clostridiales and Blautia species. In 6 of the 10 responding donor FMT recipients, immunosuppressant drug therapy was successfully tapered. Durable remission of steroid-refractory or steroid-dependent GvHD after donor FMT was associated with improved survival at 24 weeks after donor FMT. This study highlights the potential of donor FMT as a treatment for steroid-refractory or steroid-dependent GvHD, but larger clinical trials are needed to confirm the safety and efficacy of this procedure.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
7001 a Davids, M.4 aut
7001 a Haverkate, N. J. E.4 aut
7001 a de Groot, P. F.4 aut
7001 a Donker, M. L.4 aut
7001 a Meijer, E.4 aut
7001 a Heubel-Moenen, Fcji4 aut
7001 a Nur, E.4 aut
7001 a Zeerleder, S. S.4 aut
7001 a Nieuwdorp, Maxu Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xnieum
7001 a Blom, B.4 aut
7001 a Hazenberg, M. D.4 aut
7102 a Göteborgs universitetb Wallenberglaboratoriet4 org
7730 t Science Translational Medicined : American Association for the Advancement of Science (AAAS)g 12:556q 12:556x 1946-6234x 1946-6242
8564 8u https://gup.ub.gu.se/publication/296463
8564 8u https://doi.org/10.1126/scitranslmed.aaz8926

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