Sökning: WFRF:(Oresic M) > Link between plasma...
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000 | 05325naa a2200493 4500 | |
001 | oai:DiVA.org:oru-70945 | |
003 | SwePub | |
008 | 190826s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-709452 URI |
024 | 7 | a https://doi.org/10.1007/s00125-009-1482-92 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a de Mello, V. D. F.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut |
245 | 1 0 | a Link between plasma ceramides, inflammation and insulin resistance :b association with serum IL-6 concentration in patients with coronary heart disease |
264 | c 2009-08-11 | |
264 | 1 | b Springer,c 2009 |
338 | a print2 rdacarrier | |
520 | a AIMS/HYPOTHESIS: Ceramides and IL-6 have a role in immune-inflammatory responses and cardiovascular diseases, and are suggested to be involved in insulin and glucose metabolism. We sought to assess the associations of circulating levels of IL-6, TNF-alpha and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD.METHODS: Cross-sectional analyses were carried out on data from 33 patients with CHD. Serum levels of the inflammatory markers and plasma lipid metabolites (lipidomics approach performed by ultra-performance liquid chromatography coupled to electrospray ionisation MS) were measured at the same time point as insulin resistance (IR) (HOMA-IR index).RESULTS: Serum circulating levels of IL-6 were strongly correlated with plasma ceramide concentrations (r = 0.59, p < 0.001). Adjustments for serum TNF-alpha or hsCRP levels, smoking, BMI, age, sex or HOMA-IR did not change the results (p < 0.001). After adjustments for the effect of serum inflammatory markers (TNF-alpha or hsCRP), HOMA-IR and BMI the correlation between plasma DAG and serum IL-6 (r = 0.33) was also significant (p < 0.03). In a linear regression model, circulating levels of both ceramides and TNF-alpha had a significant independent influence on circulating levels of IL-6, altogether accounting for 41% of its variation (p < 0.001).CONCLUSIONS/INTERPRETATION: Our results strongly suggest that the link between ceramides, IR and inflammation is related to the inflammatory marker IL-6. Ceramides may contribute to the induction of inflammation involved in IR states that frequently coexist with CHD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
653 | a Cardiovascular disease | |
653 | a Ceramides | |
653 | a Diacylglycerols | |
653 | a IL-6 | |
653 | a Inflammation | |
653 | a Insulin resistance | |
653 | a Lipidomics | |
700 | 1 | a Lankinen, M.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland4 aut |
700 | 1 | a Schwab, U.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland4 aut |
700 | 1 | a Kolehmainen, M.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut |
700 | 1 | a Lehto, S.u Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland4 aut |
700 | 1 | a Seppänen-Laakso, T.u VTT Technical Research Centre of Finland, Espoo, Finland4 aut |
700 | 1 | a Oresic, Matej,d 1967-u VTT Technical Research Centre of Finland, Espoo, Finland4 aut0 (Swepub:oru)moc |
700 | 1 | a Pulkkinen, L.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut |
700 | 1 | a Uusitupa, Mu Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut |
700 | 1 | a Erkkilä, A. T.u Department of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut |
710 | 2 | a Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finlandb Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland4 org |
773 | 0 | t Diabetologiad : Springerg 52:12, s. 2612-2615q 52:12<2612-2615x 0012-186Xx 1432-0428 |
856 | 4 | u https://link.springer.com/content/pdf/10.1007%2Fs00125-009-1482-9.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70945 |
856 | 4 8 | u https://doi.org/10.1007/s00125-009-1482-9 |
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