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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005325naa a2200493 4500
001oai:DiVA.org:oru-70945
003SwePub
008190826s2009 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-709452 URI
0247 a https://doi.org/10.1007/s00125-009-1482-92 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a de Mello, V. D. F.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
2451 0a Link between plasma ceramides, inflammation and insulin resistance :b association with serum IL-6 concentration in patients with coronary heart disease
264 c 2009-08-11
264 1b Springer,c 2009
338 a print2 rdacarrier
520 a AIMS/HYPOTHESIS: Ceramides and IL-6 have a role in immune-inflammatory responses and cardiovascular diseases, and are suggested to be involved in insulin and glucose metabolism. We sought to assess the associations of circulating levels of IL-6, TNF-alpha and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD.METHODS: Cross-sectional analyses were carried out on data from 33 patients with CHD. Serum levels of the inflammatory markers and plasma lipid metabolites (lipidomics approach performed by ultra-performance liquid chromatography coupled to electrospray ionisation MS) were measured at the same time point as insulin resistance (IR) (HOMA-IR index).RESULTS: Serum circulating levels of IL-6 were strongly correlated with plasma ceramide concentrations (r = 0.59, p < 0.001). Adjustments for serum TNF-alpha or hsCRP levels, smoking, BMI, age, sex or HOMA-IR did not change the results (p < 0.001). After adjustments for the effect of serum inflammatory markers (TNF-alpha or hsCRP), HOMA-IR and BMI the correlation between plasma DAG and serum IL-6 (r = 0.33) was also significant (p < 0.03). In a linear regression model, circulating levels of both ceramides and TNF-alpha had a significant independent influence on circulating levels of IL-6, altogether accounting for 41% of its variation (p < 0.001).CONCLUSIONS/INTERPRETATION: Our results strongly suggest that the link between ceramides, IR and inflammation is related to the inflammatory marker IL-6. Ceramides may contribute to the induction of inflammation involved in IR states that frequently coexist with CHD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
653 a Cardiovascular disease
653 a Ceramides
653 a Diacylglycerols
653 a IL-6
653 a Inflammation
653 a Insulin resistance
653 a Lipidomics
7001 a Lankinen, M.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland4 aut
7001 a Schwab, U.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland4 aut
7001 a Kolehmainen, M.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
7001 a Lehto, S.u Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland4 aut
7001 a Seppänen-Laakso, T.u VTT Technical Research Centre of Finland, Espoo, Finland4 aut
7001 a Oresic, Matej,d 1967-u VTT Technical Research Centre of Finland, Espoo, Finland4 aut0 (Swepub:oru)moc
7001 a Pulkkinen, L.u Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
7001 a Uusitupa, Mu Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
7001 a Erkkilä, A. T.u Department of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland4 aut
7102 a Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finlandb Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland4 org
7730 t Diabetologiad : Springerg 52:12, s. 2612-2615q 52:12<2612-2615x 0012-186Xx 1432-0428
8564 u https://link.springer.com/content/pdf/10.1007%2Fs00125-009-1482-9.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70945
8564 8u https://doi.org/10.1007/s00125-009-1482-9

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