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Sökning: WFRF:(Ossenkoppele Gert) > European Stop Tyros...

European Stop Tyrosine Kinase Inhibitor Trial (EURO-SKI) in Chronic Myeloid Leukemia : Final Analysis and Novel Prognostic Factors for Treatment-Free Remission

Mahon, Francois-Xavier (författare)
Univ Bordeaux, UMR1312 Inserm, Bergonie Canc Inst, INSERM, Bordeaux, France.;Inst Bergonie, 229 cours Argonne, F-33076 Bordeaux, France.
Pfirrmann, Markus (författare)
LMU Munchen, Inst Med Informationsverarbeitung Biomet & Epidemi, Med Fak, Munich, Germany.
Dulucq, Stephanie (författare)
Univ Hosp Bordeaux, Lab Hematol, Hop Haut Leveque, Pessac, France.;Ctr Leon Berard, Grp Fi LMC, Lyon, France.
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Hochhaus, Andreas (författare)
Univ klinikum Jena, Klin Innere Med II, Jena, Germany.
Panayiotidis, Panayiotis (författare)
Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Athens, Greece.
Almeida, Antonio (författare)
Univ Catolica Portuguesa, Fac Med, Lisbon, Portugal.
Mayer, Jiri (författare)
Masaryk Univ, Dept Internal Med Hematol & Oncol, Brno, Czech Republic.;Univ Hosp Brno, Brno, Czech Republic.
Hjorth-Hansen, Henrik (författare)
St Olavs Hosp HF, Trondheim, Norway.
Janssen, Jeroen J. W. M. (författare)
Amsterdam UMC, Dept Hematol, Locat VUMC, Amsterdam, Netherlands.
Mustjoki, Satu (författare)
Univ Helsinki, Hematol Res Unit Helsinki, Helsinki, Finland.;Univ Helsinki, Translat Immunol Res Program, Helsinki, Finland.;Univ Helsinki, Comprehens Canc Ctr, Helsinki, Finland.;ICAN Digital Precis Canc Med Flagship, Helsinki, Finland.
Martinez-Lopez, Joaquin (författare)
Univ Complutense, Hosp 12 Octubre, CNIO I 12, Dept Med, Madrid, Spain.
Vestergaard, Hanne (författare)
Ramboll Denmark, Copenhagen, Denmark.
Ehrencrona, Hans (författare)
Reg Skane, Dept Genet & Pathol, Lab Med, Lund, Sweden.;AI Sweden, Lund, Sweden.
Polakova, Katerina Machova (författare)
Inst Hematol & Blood Transfus, Prague, Czech Republic.
Olsson-Strömberg, Ulla (författare)
Univ Hosp, Dept Med Sci, Uppsala, Sweden.;Univ Hosp, Div Hematol, Uppsala, Sweden.
Ossenkoppele, Gert (författare)
Amsterdam UMC, Dept Hematol, Locat VUMC, Amsterdam, Netherlands.
Berger, Marc G. (författare)
CHU Estaing, Hematol Biol, Clermont Ferrand, France.;CHU Estaing, EA 7453 CHELTER, Clermont Ferrand, France.;Univ Clermont Auvergne, Clermont Ferrand, France.
Etienne, Gabriel (författare)
Ctr Leon Berard, Grp Fi LMC, Lyon, France.;Inst Bergonie, Hematol Dept, Bordeaux, France.
Dengler, Jolanta (författare)
Onkol Schwerpunktpraxis Heilbronn, Heilbronn, Germany.;Diakonie Klinikum, Innere Med 3, Schwab Hall, Germany.
Bruemmendorf, Tim H. (författare)
Rhein Westfal TH Aachen, Dept Hematol Oncol Hemostaseol & Stem Cell Transp, Med Fac, Aachen, Germany.;Aachen Bonn Cologne Dusseldorf CIO ABCD, Ctr Integrated Oncol, Aachen, Germany.
Burchert, Andreas (författare)
Philipps Univ Marburg, Dept Hematol Oncol & Immunol, Fac Med, Marburg, Germany.
Rea, Delphine (författare)
Hop St Louis, Serv dHematol Adulte, Paris, France.;Hop St Louis, INSERM UMR 1160, Paris, France.
Rousselot, Philippe (författare)
Univ Versailles Paris Saclay, Ctr Hosp Versailles, Dept Hematol, INSERM UMR 1184, Le Chesnay, France.
Nicolini, Franck E. (författare)
Ctr Leon Berard, Lyon, France.
Hofmann, Wolf-Karsten (författare)
Heidelberg Univ, Univ Hosp Mannheim, Dept Hematol & Oncol, Mannheim, Germany.
Richter, Johan (författare)
Skane Univ Hosp, Dept Haematol Oncol & Radiat Phys, Lund, Sweden.
Saussele, Susanne (författare)
Heidelberg Univ, Univ Hosp Mannheim, Dept Hematol & Oncol, Mannheim, Germany.
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Univ Bordeaux, UMR1312 Inserm, Bergonie Canc Inst, INSERM, Bordeaux, France;Inst Bergonie, 229 cours Argonne, F-33076 Bordeaux, France. LMU Munchen, Inst Med Informationsverarbeitung Biomet & Epidemi, Med Fak, Munich, Germany. (creator_code:org_t)
American Society of Clinical Oncology (ASCO), 2024
2024
Engelska.
Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 42:16
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.The European Stop Kinase Inhibitors (EURO-SKI) study is the largest clinical trial for investigating the cessation of tyrosine kinase inhibitors (TKIs) in patients with chronic myeloid leukemia in stable deep molecular remission (DMR). Among 728 patients, 434 patients (61%; 95% CI, 57 to 64) remained in major molecular response (MMR) at 6 months and 309 patients of 678 (46%; 95% CI, 42 to 49) at 36 months. Duration of TKI treatment and DMR before TKI stop were confirmed as significant factors for the prediction of MMR loss at 6 months. In addition, the type of BCR::ABL1 transcript was identified as a prognostic factor. For late MMR losses after 6 months, TKI treatment duration, percentage of blasts in peripheral blood, and platelet count at diagnosis were significant factors in multivariate analysis. For the entire study period of 36 months, multiple logistic regression models confirmed duration of treatment, blasts, and transcript type as independent factors for MMR maintenance. In addition to the duration of treatment, transcript type as well as blasts in peripheral blood at diagnosis should be considered as important factors to predict treatment-free remission.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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