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WFRF:(Thompson Alastair M)
 

Sökning: WFRF:(Thompson Alastair M) > Genomic aberrations...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004357naa a2200649 4500
001oai:gup.ub.gu.se/297407
003SwePub
008240528s2021 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2974072 URI
0247 a https://doi.org/10.1158/1078-0432.CCR-20-01262 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Guerini-Rocco, Elena4 aut
2451 0a Genomic aberrations and late recurrence in postmenopausal women with hormone receptor-positive early breast cancer: Results from the SOLE Trial.
264 1c 2021
520 a Women with hormone-receptor-positive early breast cancers have a persistent risk of relapse and biomarkers for late recurrence are needed. We sought to identify tumor genomic aberrations associated with increased late recurrence risk.In a secondary analysis of Study of Letrozole Extension (SOLE) trial, a case-cohort-like sampling selected 598 primary breast cancer for targeted next-generation sequencing (NGS) analysis of gene mutations and copy number gains (CNG). Correlations of genomic aberrations with clinicopathologic factors and breast and distant recurrence free-intervals (BCFI and DRFI) were analyzed using weighted Cox models.Analysis of mutations and CNG was successfully performed for 403 and 350 samples, including 148 and 134 patients with breast cancer recurrences (median follow-up time: 5.2 years), respectively. The most frequent alterations were PIK3CA mutations (42%) and CNGs of CCND1 (15%), ERBB2 (10%), FGFR1 (8%) and MYC (8%). PIK3CA mutations and MYC CNG were associated with lower (p=0.03) and higher (p=0.004) tumor grade respectively; a higher Ki67 was seen in tumor with CCND1, ERBB2 and MYC CNGs (p=0.01, <0.001 and 0.03 respectively). FGFR1 CNG was associated with an increased risk of late events in univariate analyses (17/29 patients; BCFI: HR=3.2, 95%CI: 1.48-6.92, p =0.003; DRFI: HR=3.5, 95%CI: 1.61-7.75, p=0.002) and in multivariable models adjusted for clinicopathologic factors.Postmenopausal women with hormone receptor-positive early breast cancer harboring FGFR1 CNG had an increased risk of late recurrence despite extended therapy. FGFR1 CNG may represent a useful prognostic biomarker for late recurrence and a therapeutic target.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Gray, Kathryn P4 aut
7001 a Fumagalli, Caterina4 aut
7001 a Reforgiato, Marta Rita4 aut
7001 a Leone, Isabella4 aut
7001 a Rafaniello Raviele, Paola4 aut
7001 a Munzone, Elisabetta4 aut
7001 a Kammler, Roswitha4 aut
7001 a Neven, Patrick4 aut
7001 a Hitre, Erika4 aut
7001 a Jerusalem, Guy4 aut
7001 a Simoncini, Edda L4 aut
7001 a Gombos, Andrea4 aut
7001 a Deleu, Ines4 aut
7001 a Karlsson, Per,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology4 aut0 (Swepub:gu)xkperd
7001 a Aebi, Stefan4 aut
7001 a Chirgwin, Jacquie4 aut
7001 a Di Lauro, Vincenzo4 aut
7001 a Thompson, Alastair M4 aut
7001 a Graas, Marie-Pascale4 aut
7001 a Barber, Matthew4 aut
7001 a Fontaine, Christel4 aut
7001 a Loibl, Sibylle4 aut
7001 a Gavilá, Joaquín4 aut
7001 a Kuroi, Katsumasa4 aut
7001 a Müller, Bettina4 aut
7001 a O'Reilly, Seamus4 aut
7001 a Di Leo, Angelo4 aut
7001 a Goldhirsch, Aron4 aut
7001 a Viale, Giuseppe4 aut
7001 a Barberis, Massimo4 aut
7001 a Regan, Meredith M4 aut
7001 a Colleoni, Marco4 aut
7102 a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för onkologi4 org
7730 t Clinical cancer research : an official journal of the American Association for Cancer Researchg 27:2, s. 504-512q 27:2<504-512x 1078-0432
8564 8u https://gup.ub.gu.se/publication/297407
8564 8u https://doi.org/10.1158/1078-0432.CCR-20-0126

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