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WFRF:(Bonde Jens Peter)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004833naa a2200541 4500
001oai:lup.lub.lu.se:559b2293-5f93-4346-93a0-b77182e31fca
003SwePub
008160401s2008 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/11935932 URI
0247 a https://doi.org/10.1289/ehp.107002 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a for2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Bonde, Jens Peter4 aut
2451 0a Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines
264 1b Environmental Health Perspectives,c 2008
520 a OBJECTIVE: We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. DATA SOURCES AND EXTRACTION: We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core papers. DATA SYNTHESIS: The study did not provide direct evidence of hormone-like activity of the polychlorinated biphenyl (PCB) congener CB-153 and the main dichlorodiphenyltrichloroethane (DDT) metabolite, 1 1 1 -dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p'-DDE), as serum concentrations of these compounds were not consistently related to either endogenous or exogenous hormone activity in serum. Nevertheless several links bewteen POP exposure and biomarkers of male reproductive function were identified. First, an association between high CB-153 serum levels and low sperm counts was detected within a subgroup of men with short androgen receptor CAG repeat length. Second, a relationship between increased CB-153 serum concentrations and decreased sperm motility was seen in all four studied regions, and indications of reduced neutral alpha-glucosidase activity in seminal plasma point to a post-testicular effect. Third, damage of sperm chromatin integrity was considerably less frequent in Greenlandic Inuits compared with that in European groups, and only in the latter was impairment of sperm chromatin integrity related to POPs. Despite these effects, fertility in terms of time taken to conceive was not related to POPs except in Inuits. A likely explanation of the latter was not identified. CONCLUSIONS: POPs may interfere with male reproductive function without major impact on fertility. The data do not provide direct evidence for endocrine disruption, hence other mechanisms should also be considered.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653 a xenobiotics
653 a time to pregnancy
653 a receptors
653 a sex hormone
653 a semen quality
653 a reproductive health
653 a inuit
653 a polymorphisms
7001 a Toftl, Gunnar4 aut
7001 a Rylander, Larsu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-lry
7001 a Rignell-Hydbom, Annau Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-arh
7001 a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-agi
7001 a Spano, Marcelli4 aut
7001 a Manicardi, Gian Carlo4 aut
7001 a Bizzaro, Davide4 aut
7001 a Ludwicki, Jan K.4 aut
7001 a Zvyezday, Valentina4 aut
7001 a Bonefeld-Jorgensen, Eva C.4 aut
7001 a Pedersen, Henning Sloth4 aut
7001 a Joensson, Bo A. G.4 aut
7001 a Thulstrup, Ane Marie4 aut
7102 a Avdelningen för arbets- och miljömedicinb Institutionen för laboratoriemedicin4 org
7730 t Environmental Health Perspectivesd : Environmental Health Perspectivesg 116:3, s. 269-277q 116:3<269-277x 1552-9924x 0091-6765
8564 u http://dx.doi.org/10.1289/ehp.10700x freey FULLTEXT
8564 u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265036/pdf/ehp0116-000269.pdf
8564 8u https://lup.lub.lu.se/record/1193593
8564 8u https://doi.org/10.1289/ehp.10700

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