Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract

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Fältnamn	Indikatorer	Metadata
000		04432naa a2200601 4500
001		oai:gup.ub.gu.se/267302
003		SwePub
008		240528s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2673022 URI
024	7	a https://doi.org/10.1093/eurheartj/ehy1822 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Mach, François4 aut
245	1 0	a Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract
264		c 2018-04-27
264	1	b Oxford University Press (OUP),c 2018
520		a To objectively appraise evidence for possible adverse effects of long-term statin therapy on glucose homeostasis, cognitive, renal and hepatic function, and risk for haemorrhagic stroke or cataract.A literature search covering 2000-2017 was performed. The Panel critically appraised the data and agreed by consensus on the categorization of reported adverse effects. Randomized controlled trials (RCTs) and genetic studies show that statin therapy is associated with a modest increase in the risk of new-onset diabetes mellitus (about one per thousand patient-years), generally defined by laboratory findings (glycated haemoglobin ≥6.5); this risk is significantly higher in the metabolic syndrome or prediabetes. Statin treatment does not adversely affect cognitive function, even at very low levels of low-density lipoprotein cholesterol and is not associated with clinically significant deterioration of renal function, or development of cataract. Transient increases in liver enzymes occur in 0.5-2% of patients taking statins but are not clinically relevant; idiosyncratic liver injury due to statins is very rare and causality difficult to prove. The evidence base does not support an increased risk of haemorrhagic stroke in individuals without cerebrovascular disease; a small increase in risk was suggested by the Stroke Prevention by Aggressive Reduction of Cholesterol Levels study in subjects with prior stroke but has not been confirmed in the substantive evidence base of RCTs, cohort studies and case-control studies.Long-term statin treatment is remarkably safe with a low risk of clinically relevant adverse effects as defined above; statin-associated muscle symptoms were discussed in a previous Consensus Statement. Importantly, the established cardiovascular benefits of statin therapy far outweigh the risk of adverse effects.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Ray, Kausik K4 aut
700	1	a Wiklund, Olov,d 1943u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xwikol
700	1	a Corsini, Alberto4 aut
700	1	a Catapano, Alberico L4 aut
700	1	a Bruckert, Eric4 aut
700	1	a De Backer, Guy4 aut
700	1	a Hegele, Robert A4 aut
700	1	a Hovingh, G Kees4 aut
700	1	a Jacobson, Terry A4 aut
700	1	a Krauss, Ronald M4 aut
700	1	a Laufs, Ulrich4 aut
700	1	a Leiter, Lawrence A4 aut
700	1	a März, Winfried4 aut
700	1	a Nordestgaard, Børge G4 aut
700	1	a Raal, Frederick J4 aut
700	1	a Roden, Michael4 aut
700	1	a Santos, Raul D4 aut
700	1	a Stein, Evan A4 aut
700	1	a Stroes, Erik S4 aut
700	1	a Thompson, Paul D4 aut
700	1	a Tokgözoglu, Lale4 aut
700	1	a Vladutiu, Georgirene D4 aut
700	1	a Gencer, Baris4 aut
700	1	a Stock, Jane K4 aut
700	1	a Ginsberg, Henry N4 aut
700	1	a Chapman, M John4 aut
710	2	a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
773	0	t European heart journald : Oxford University Press (OUP)g 39:27q 39:27x 1522-9645x 0195-668X
856	4	u https://academic.oup.com/eurheartj/article-pdf/39/27/2526/25161843/ehy182.pdf
856	4 8	u https://gup.ub.gu.se/publication/267302
856	4 8	u https://doi.org/10.1093/eurheartj/ehy182

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