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Choosing Between Ol...
Choosing Between Older Matched Sibling Donor and Younger Matched Unrelated Donor in Allogeneic Hematopoietic Cell Transplantation : Comparison of Clinical Outcomes in Acute Myeloid Leukemia and Myelodysplastic Syndrome
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- Pereira, Mariana Pinto (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.
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- Remberger, Mats, Professor, 1955- (författare)
- Uppsala universitet,Hematologi,Uppsala Univ Hosp, KFUE, Uppsala, Sweden.
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- Chen, Carol (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.
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- Gerbitz, Armin (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.
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- Kim, Dennis Dong Hwan (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.
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- Kumar, Rajat (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.
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- Lam, Wilson (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.
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- Law, Arjun Datt (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.
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- Lipton, Jeffrey H. (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.
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- V. Michelis, Fotios (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.
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- Novitzky-Basso, Igor (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.
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- Viswabandya, Auro (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.
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- Mattsson, Jonas (författare)
- Karolinska Institutet
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- Pasic, Ivan (författare)
- Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.;Princess Margaret Hosp, Div Med Oncol & Hematol, 610 Univ Ave, Room 700U 6-606, Toronto, ON M5G 2M9, Canada.
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Princess Margaret Hosp, Hans Messner Allogene Transplant Program, Div Med Oncol & Hematol, Toronto, ON, Canada Hematologi (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Transplantation and Cellular Therapy. - : Elsevier. - 2666-6375 .- 2666-6367. ; 29:11
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The choice between an older matched sibling donor (MSD) and a younger matched unrelated donor (MUD) in allogeneic hematopoietic cell transplantation (HCT) remains a subject of ongoing debate. In this single-center retrospective study of 377 patients who received peripheral blood stem cell (PBSC) transplants for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), we compared outcomes of 85 patients who received grafts from MSDs age >60 years and 292 patients who received grafts from MUDs age <30 years. Compared to recipients of MSD transplants, recipients of MUD transplants were younger and more likely to receive dual T cell depletion (TCD), a higher CD34(+) cell dose, and a fresh graft. Recipients of MSD transplants were maintained on immunosuppressive therapy longer than those who received MUD grafts. We found no differences in overall survival, relapse-free survival, graft-versus-host disease (GVHD)-free and relapse-free survival, nonrelapse mortality, relapse, engraftment, graft failure, and acute GVHD between recipients of MSD grafts and recipients of MUD grafts. We report a higher 30-day incidence, but not 1-year incidence, of bloodstream infections among recipients of MUD transplants compared to subjects who received their grafts from a MSD. The incidence of moderate-severe chronic GVHD was higher in MSD graft recipients compared with MUD graft recipients in univariate analysis, but not in multivariate analysis. Although this difference could reflect the greater use of dual TCD, known to be associated with very low rates of chronic GVHD in MUD transplant recipients, the incidence of moderate-severe chronic GVHD was no different between MSD and MUD transplant recipients following propensity score matching, suggesting that other variables could be responsible. Taken together, our data suggest that in patients with AML or MDS who receive PBSC transplants, such factors as convenience, ease of access, and costs should be considered when selecting an older MSD over a younger MUD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Allogeneic hematopoietic cell
- transplantation
- Matched sibling donor
- Matched unrelated donor
- Donor age
- Acute myeloid leukemia
- Myelodysplastic syndrome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Pereira, Mariana ...
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Remberger, Mats, ...
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Chen, Carol
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Gerbitz, Armin
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Kim, Dennis Dong ...
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Kumar, Rajat
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visa fler...
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Lam, Wilson
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Law, Arjun Datt
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Lipton, Jeffrey ...
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V. Michelis, Fot ...
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Novitzky-Basso, ...
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Viswabandya, Aur ...
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Mattsson, Jonas
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Pasic, Ivan
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Transplantation ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet