Sökning: WFRF:(Michelis Fotios V) >
Relationship betwee...
Relationship between certain HLA alleles and the risk of cytomegalovirus reactivation following allogeneic hematopoietic stem cell transplantation
-
- Prem, Shruti (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
- Remberger, Mats, Professor, 1955- (författare)
- Uppsala universitet,Hematologi,Uppsala Univ Hosp, KFUE, Uppsala, Sweden.
-
- Alotaibi, Ahmad (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
visa fler...
-
- Lam, Wilson (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
- Law, Arjun Datt (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
- Kim, Dennis (Dong Hwan) (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
- Michelis, Fotios, V (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
- Al-Shaibani, Zeyad (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
- Lipton, Jeffrey Howard (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
- Mattsson, Jonas (författare)
- Karolinska Institutet
-
- Viswabandya, Auro (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
- Kumar, Rajat (författare)
- Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
-
- Ellison, Cynthia (författare)
- Univ Hlth Network, Messner Allogene Transplant Program, Div HLA Lab, Lab Med Program, Toronto, ON, Canada.;Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
-
visa färre...
-
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada. Hematologi (creator_code:org_t)
- 2022-07-13
- 2022
- Engelska.
-
Ingår i: Transplant Infectious Disease. - : John Wiley & Sons. - 1398-2273 .- 1399-3062. ; 24:4
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Introduction: Evidence is emerging to support an association between certain human leukocyte antigen (HLA) alleles and the risk of cytomegalovirus (CMV) reactivation following allogeneic hematopoietic stem cell transplant (allo-HSCT). The primary aim of this study was to identify HLA alleles associated with resistance or susceptibility to CMV reactivation. Methods: We studied 586 adults who underwent al lo-HSCT for high-risk hematological malignancies. High-resolution HLA typing data were available for recipients and donors. HLA class I and II alleles observed at a frequency of >5% in our population were included in the analysis. A CMV viremia level of more than 200 IU/ml on weekly monitoring was considered to be indicative of CMV reactivation. Results: The median follow-up time in surviving patients was 21 months (range 4-74 months). The cumulative incidence of CMV reactivation at 6 months in the entire cohort was 55% (95% confidence interval [CI] 50.8%-59.2%). Mismatched donors, increasing recipient age, occurrence of acute graft versus host disease and recipient CMV seropositivity were associated with an increased risk of CMV reactivation. HLA B*07:02 (hazard ratio 0.59, 95% CI 0.40-0.83) was associated with a decreased risk of CMV reactivation. Patients who developed CMV reactivation had a lower incidence of relapse, higher transplant-related mortality (TRM) and lower overall survival (OS) than those without CMV reactivation. There was an adverse correlation of OS and TRM with increasing numbers of CMV reactivations. Conclusion: We observed that HLA B*07:02 was associated with a decreased risk of CMV reactivation. CMV reactivation was associated with lower relapse post-transplant, but this did not translate into a survival benefit due to higher TRM.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- allogenic hematopoietic stem cell transplant
- cytomegalovirus reactivation
- HLA alleles
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Prem, Shruti
-
Remberger, Mats, ...
-
Alotaibi, Ahmad
-
Lam, Wilson
-
Law, Arjun Datt
-
Kim, Dennis (Don ...
-
visa fler...
-
Michelis, Fotios ...
-
Al-Shaibani, Zey ...
-
Lipton, Jeffrey ...
-
Mattsson, Jonas
-
Viswabandya, Aur ...
-
Kumar, Rajat
-
Ellison, Cynthia
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Transplant Infec ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet