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Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation
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- Yaroshenko, A. (author)
- Technical University of Munich
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- Meinel, F. G. (author)
- University Hospital Munich
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- Bech, M. (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Technical University of Munich
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- (creator_code:org_t)
- 2013
- 2013
- English.
- In: ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging : From Nano to Macro - From Nano to Macro. - 1945-7928 .- 1945-8452. - 9781467364553 - 9781467364560 ; , s. 370-373
- Conference paper (peer-reviewed)
Abstract
Subject headings
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- Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- dark-field
- emphysema
- grating interferometer
- phase-contrast
- x-ray
Publication and Content Type
- kon (subject category)
- ref (subject category)
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- Yaroshenko, A.
- Meinel, F. G.
- Bech, M.
- Tapfer, A.
- Velroyen, A.
- Schleede, S.
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- Muller, M.
- Auweter, S.
- Bohla, A.
- Yildirim, A. O.
- Nikolaou, K.
- Bamberg, F.
- Eickelberg, O.
- Reiser, M.
- Pfeiffer, F.
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