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Increased subsarcolemmal lipids in type 2 diabetes : effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle.
- Nielsen, Joachim (author)
- Mogensen, Martin (author)
- Vind, Birgitte F (author)
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- Højlund, Kurt (author)
- Schrøder, Henrik D (author)
- Ortenblad, Niels (author)
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- (creator_code:org_t)
- American Physiological Society, 2010
- 2010
- English.
- In: American Journal of Physiology. Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 298:3, s. E706-13
- Journal article (peer-reviewed)
Abstract
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- The purpose of the study was to investigate the effect of aerobic training and type 2 diabetes on intramyocellular localization of lipids, mitochondria, and glycogen. Obese type 2 diabetic patients (n = 12) and matched obese controls (n = 12) participated in aerobic cycling training for 10 wk. Endurance-trained athletes (n = 15) were included for comparison. Insulin action was determined by euglycemic-hyperinsulinemic clamp. Intramyocellular contents of lipids, mitochondria, and glycogen at different subcellular compartments were assessed by transmission electron microscopy in biopsies obtained from vastus lateralis muscle. Type 2 diabetic patients were more insulin resistant than obese controls and had threefold higher volume of subsarcolemmal (SS) lipids compared with obese controls and endurance-trained subjects. No difference was found in intermyofibrillar lipids. Importantly, following aerobic training, this excess SS lipid volume was lowered by approximately 50%, approaching the levels observed in the nondiabetic subjects. A strong inverse association between insulin sensitivity and SS lipid volume was found (r(2)=0.62, P = 0.002). The volume density and localization of mitochondria and glycogen were the same in type 2 diabetic patients and control subjects, and showed in parallel with improved insulin sensitivity a similar increase in response to training, however, with a more pronounced increase in SS mitochondria and SS glycogen than in other localizations. In conclusion, this study, estimating intramyocellular localization of lipids, mitochondria, and glycogen, indicates that type 2 diabetic patients may be exposed to increased levels of SS lipids. Thus consideration of cell compartmentation may advance the understanding of the role of lipids in muscle function and type 2 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Physiology
- Fysiologi
- Medicin/Teknik
- Medicine/Technology
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- ref (subject category)
- art (subject category)
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- Nielsen, Joachim
- Mogensen, Martin
- Vind, Birgitte F
- Sahlin, Kent
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- Schrøder, Henrik ...
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- Ortenblad, Niels
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- MEDICAL AND HEALTH SCIENCES
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- and Physiology
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- The Swedish School of Sport and Health Sciences
- Karolinska Institutet
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