Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study

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Ginsberg, YlvaKarolinska Institutet (författare)

Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring : a quasi-experimental family-based study

Artikel/kapitelEngelska2019

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2018-08-23
Blackwell Publishing,2019
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LIBRIS-ID:oai:DiVA.org:oru-68597
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68597URI
https://doi.org/10.1111/jcpp.12959DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:140078643URI

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Språk:engelska
Sammanfattning på:engelska

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Funding Agency:Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) 340-2013-5867
BACKGROUND: Maternal infection during pregnancy (IDP) has been associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring. However, infection is associated with social adversity, poor living conditions and other background familial factors. As such, there is a need to rule out whether the observed association between maternal IDP and ADHD might be attributed to such confounding.METHODS: This nationwide population-based cohort study using a family-based, quasi-experimental design included 1,066,956 individuals born in Sweden between 1992 and 2002. Data on maternal IDP (bacterial or viral) requiring hospitalization and ADHD diagnosis in offspring were gathered from Swedish National Registers, with individuals followed up through the end of 2009. Ordinary and stratified Cox regression models were used for estimation of hazard ratios (HRs) and several measured covariates were considered. Cousin- and sibling-comparisons accounted for unmeasured genetic and environmental factors shared by cousins and siblings.RESULTS: In the entire population, maternal IDP was associated with ADHD in offspring (HR = 2.31, 95% CI = 2.04-2.61). This association was attenuated when accounting for measured covariates (HR = 1.86, 95% CI = 1.65-2.10). The association was further attenuated when adjusting for unmeasured factors shared between cousins (HR = 1.52, 95% CI = 1.12-2.07). Finally, the association was fully attenuated in sibling comparisons (HR = 1.03, 95% CI = 0.76-1.41).CONCLUSIONS: This study suggests that the association between maternal IDP and offspring ADHD is largely due to unmeasured familial confounding. Our results underscore the importance of adjusting for unobserved familial risk factors when exploring risk factors for ADHD.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
Maternal infection during pregnancy
attention-deficit/hyperactivity disorder
cousin comparisons
familial confounding
quasi-experimental
sibling comparisons

Biuppslag (personer, institutioner, konferenser, titlar ...)

D'Onofrio, Brian M.Karolinska Institutet (författare)
Rickert, Martin E.Indiana University, Bloomington IN, USA (författare)
Class, Quetzal A.Karolinska Institutet (författare)
Rosenqvist, Mina A.Karolinska Institutet (författare)
Almqvist, CatarinaKarolinska Institutet, Stockholm, Sweden; Astrid Lindgren Children′s Hospital, Karolinska University Hospital, Stockholm, Sweden (författare)
Lichtenstein, PaulKarolinska Institutet (författare)
Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln (författare)
Karolinska InstitutetIndiana University, Bloomington IN, USA (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Child Psychology and Psychiatry: Blackwell Publishing60:2, s. 160-1680021-96301469-7610

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Av författaren/redakt...: Ginsberg, Ylva; D'Onofrio, Brian ...; Rickert, Martin ...; Class, Quetzal A ...; Rosenqvist, Mina ...; Almqvist, Catari ...; visa fler...; Lichtenstein, Pa ...; Larsson, Henrik, ...; visa färre...

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