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Axonal tracing of t...
Axonal tracing of the normal and regenerating visual pathway of mouse, rat, frog, and fish using manganese-enhanced MRI (MEMRI)
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- Sandvig, Axel (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Sandvig, Ioanna (författare)
- Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
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- Berry, Martin (författare)
- Molecular Neuroscience, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
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- Olsen, Oystein (författare)
- Department of Radiography, Sør-Trondelag University College, Trondheim, Norway
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- Pedersen, Tina Bugge (författare)
- Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
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- Brekken, Christian (författare)
- Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
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- Thuen, Marte (författare)
- Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
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(creator_code:org_t)
- 2011-07-18
- 2011
- Engelska.
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Ingår i: Journal of Magnetic Resonance Imaging. - Chicago, IL : Society for Magnetic Resonance Imaging. - 1053-1807 .- 1522-2586. ; 34:3, s. 670-675
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: To assess optic nerve (ON) regeneration after injury by applying manganese-enhanced MRI (MEMRI) in a study of comparative physiology between nonregenerating rat and mouse species and regenerating frog and fish species.Materials and Methods: The normal visual projections of rats, mice, frogs, and fish was visualized by intravitreal MnCl(2) injection followed by MRI. Rats and mice with ON crush (ONC) were divided into nonregenerating (ONC only), and regenerating animals with peripheral nerve graft (ONC+PNG; rats) or lens injury (ONC+LI; mice) and monitored by MEMRI at 1 and 20 days post-lesion (dpl). Frog and fish with ON transection (ONT) were monitored by MEMRI up to 6 months postlesion (mpl).Results: Signal intensity profiles of the Mn(2+)-enhanced ON were consistent with ON regeneration in the ONC+PNG and ONC+LI rat and mice groups, respectively, compared with the nonregenerating ONC groups. Furthermore, signal intensity profiles of the Mn(2+)-enhanced ON obtained between 1 mpl and 6 mpl in the fish and frog groups, respectively, were consistent with spontaneous, complete ON regeneration.Conclusion: Taken together, these results demonstrate that MEMRI is a viable method for serial, in vivo monitoring of normal, induced, and spontaneously regenerating optic nerve axons in different species.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- CNS injury
- regeneration
- optic nerve
- axon
- in vivo imaging
- MRI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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