WFRF:(Wiggins A.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05273naa a2201357 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:153514567 | |
| 003 | SwePub | |
| 008 | 240701s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1535145672 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-023-36997-w2 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Young, WJ4 aut |
| 245 | 1 0 | a Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease |
| 264 | c 2023-03-14 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2023 |
| 520 | a The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction. | |
| 700 | 1 | a Haessler, J4 aut |
| 700 | 1 | a Benjamins, JW4 aut |
| 700 | 1 | a Repetto, L4 aut |
| 700 | 1 | a Yao, J4 aut |
| 700 | 1 | a Isaacs, A4 aut |
| 700 | 1 | a Harper, AR4 aut |
| 700 | 1 | a Ramirez, J4 aut |
| 700 | 1 | a Garnier, S4 aut |
| 700 | 1 | a van Duijvenboden, S4 aut |
| 700 | 1 | a Baldassari, AR4 aut |
| 700 | 1 | a Concas, MP4 aut |
| 700 | 1 | a Duong, T4 aut |
| 700 | 1 | a Foco, L4 aut |
| 700 | 1 | a Isaksen, JL4 aut |
| 700 | 1 | a Mei, H4 aut |
| 700 | 1 | a Noordam, R4 aut |
| 700 | 1 | a Nursyifa, C4 aut |
| 700 | 1 | a Richmond, A4 aut |
| 700 | 1 | a Santolalla, ML4 aut |
| 700 | 1 | a Sitlani, CM4 aut |
| 700 | 1 | a Soroush, N4 aut |
| 700 | 1 | a Theriault, S4 aut |
| 700 | 1 | a Trompet, S4 aut |
| 700 | 1 | a Aeschbacher, S4 aut |
| 700 | 1 | a Ahmadizar, F4 aut |
| 700 | 1 | a Alonso, A4 aut |
| 700 | 1 | a Brody, JA4 aut |
| 700 | 1 | a Campbell, A4 aut |
| 700 | 1 | a Correa, A4 aut |
| 700 | 1 | a Darbar, D4 aut |
| 700 | 1 | a De Luca, A4 aut |
| 700 | 1 | a Deleuze, JF4 aut |
| 700 | 1 | a Ellervik, C4 aut |
| 700 | 1 | a Fuchsberger, C4 aut |
| 700 | 1 | a Goel, A4 aut |
| 700 | 1 | a Grace, C4 aut |
| 700 | 1 | a Guo, XQ4 aut |
| 700 | 1 | a Hansen, T4 aut |
| 700 | 1 | a Heckbert, SR4 aut |
| 700 | 1 | a Jackson, RD4 aut |
| 700 | 1 | a Kors, JA4 aut |
| 700 | 1 | a Lima-Costa, MF4 aut |
| 700 | 1 | a Linneberg, A4 aut |
| 700 | 1 | a Macfarlane, PW4 aut |
| 700 | 1 | a Morrison, AC4 aut |
| 700 | 1 | a Navarro, P4 aut |
| 700 | 1 | a Porteous, DJ4 aut |
| 700 | 1 | a Pramstaller, PP4 aut |
| 700 | 1 | a Reiner, AP4 aut |
| 700 | 1 | a Risch, L4 aut |
| 700 | 1 | a Schotten, U4 aut |
| 700 | 1 | a Shen, X4 aut |
| 700 | 1 | a Sinagra, G4 aut |
| 700 | 1 | a Soliman, EZ4 aut |
| 700 | 1 | a Stoll, M4 aut |
| 700 | 1 | a Tarazona-Santos, E4 aut |
| 700 | 1 | a Tinker, A4 aut |
| 700 | 1 | a Trajanoska, K4 aut |
| 700 | 1 | a Villard, E4 aut |
| 700 | 1 | a Warren, HR4 aut |
| 700 | 1 | a Whitsel, EA4 aut |
| 700 | 1 | a Wiggins, KL4 aut |
| 700 | 1 | a Arking, DE4 aut |
| 700 | 1 | a Avery, CL4 aut |
| 700 | 1 | a Conen, D4 aut |
| 700 | 1 | a Girotto, G4 aut |
| 700 | 1 | a Grarup, N4 aut |
| 700 | 1 | a Hayward, C4 aut |
| 700 | 1 | a Jukema, JW4 aut |
| 700 | 1 | a Mook-Kanamori, DO4 aut |
| 700 | 1 | a Olesen, MS4 aut |
| 700 | 1 | a Padmanabhan, S4 aut |
| 700 | 1 | a Psaty, BM4 aut |
| 700 | 1 | a Pattaro, C4 aut |
| 700 | 1 | a Ribeiro, ALP4 aut |
| 700 | 1 | a Rotter, JI4 aut |
| 700 | 1 | a Stricker, BH4 aut |
| 700 | 1 | a van der Harst, P4 aut |
| 700 | 1 | a van Duijn, CM4 aut |
| 700 | 1 | a Verweij, N4 aut |
| 700 | 1 | a Wilson, JG4 aut |
| 700 | 1 | a Orini, M4 aut |
| 700 | 1 | a Charron, P4 aut |
| 700 | 1 | a Watkins, H4 aut |
| 700 | 1 | a Kooperberg, C4 aut |
| 700 | 1 | a Lin, HJ4 aut |
| 700 | 1 | a Wilson, JF4 aut |
| 700 | 1 | a Kanters, JK4 aut |
| 700 | 1 | a Sotoodehnia, N4 aut |
| 700 | 1 | a Mifsud, B4 aut |
| 700 | 1 | a Lambiase, PD4 aut |
| 700 | 1 | a Tereshchenko, LG4 aut |
| 700 | 1 | a Munroe, PB4 aut |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 14:1, s. 1411-q 14:1<1411-x 2041-1723 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:153514567 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-023-36997-w |
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- Young, WJ
- Haessler, J
- Benjamins, JW
- Repetto, L
- Yao, J
- Isaacs, A
- visa fler...
- Harper, AR
- Ramirez, J
- Garnier, S
- van Duijvenboden ...
- Baldassari, AR
- Concas, MP
- Duong, T
- Foco, L
- Isaksen, JL
- Mei, H
- Noordam, R
- Nursyifa, C
- Richmond, A
- Santolalla, ML
- Sitlani, CM
- Soroush, N
- Theriault, S
- Trompet, S
- Aeschbacher, S
- Ahmadizar, F
- Alonso, A
- Brody, JA
- Campbell, A
- Correa, A
- Darbar, D
- De Luca, A
- Deleuze, JF
- Ellervik, C
- Fuchsberger, C
- Goel, A
- Grace, C
- Guo, XQ
- Hansen, T
- Heckbert, SR
- Jackson, RD
- Kors, JA
- Lima-Costa, MF
- Linneberg, A
- Macfarlane, PW
- Morrison, AC
- Navarro, P
- Porteous, DJ
- Pramstaller, PP
- Reiner, AP
- Risch, L
- Schotten, U
- Shen, X
- Sinagra, G
- Soliman, EZ
- Stoll, M
- Tarazona-Santos, ...
- Tinker, A
- Trajanoska, K
- Villard, E
- Warren, HR
- Whitsel, EA
- Wiggins, KL
- Arking, DE
- Avery, CL
- Conen, D
- Girotto, G
- Grarup, N
- Hayward, C
- Jukema, JW
- Mook-Kanamori, D ...
- Olesen, MS
- Padmanabhan, S
- Psaty, BM
- Pattaro, C
- Ribeiro, ALP
- Rotter, JI
- Stricker, BH
- van der Harst, P
- van Duijn, CM
- Verweij, N
- Wilson, JG
- Orini, M
- Charron, P
- Watkins, H
- Kooperberg, C
- Lin, HJ
- Wilson, JF
- Kanters, JK
- Sotoodehnia, N
- Mifsud, B
- Lambiase, PD
- Tereshchenko, LG
- Munroe, PB
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