Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

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Fältnamn	Indikatorer	Metadata
000		05301naa a2200841 4500
001		oai:gup.ub.gu.se/130910
003		SwePub
008		240528s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-32699
009		oai:prod.swepub.kib.ki.se:120011220
024	7	a https://gup.ub.gu.se/publication/1309102 URI
024	7	a https://doi.org/10.1073/pnas.09140611072 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-326992 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1200112202 URI
040		a (SwePub)gud (SwePub)umud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Xu, Jianfeng4 aut
245	1 0	a Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.
264		c 2010-01-11
264	1	b Proceedings of the National Academy of Sciences,c 2010
520		a Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identification of factors specifically associated with risk for more aggressive PCa is urgently needed to reduce overdiagnosis and overtreatment of this common disease. To search for such factors, we compared the frequencies of SNPs among PCa patients who were defined as having either more aggressive or less aggressive disease in four populations examined in the Genetic Markers of Susceptibility (CGEMS) study performed by the National Cancer Institute. SNPs showing possible associations with disease severity were further evaluated in an additional three independent study populations from the United States and Sweden. In total, we studied 4,829 and 12,205 patients with more and less aggressive disease, respectively. We found that the frequency of the TT genotype of SNP rs4054823 at 17p12 was consistently higher among patients with more aggressive compared with less aggressive disease in each of the seven populations studied, with an overall P value of 2.1 x 10(-8) under a recessive model, exceeding the conservative genome-wide significance level. The difference in frequency was largest between patients with high-grade, non-organ-confined disease compared with those with low-grade, organ-confined disease. This study demonstrates that inherited variants predisposing to aggressive but not indolent PCa exist in the genome, and suggests that the clinical potential of such variants as potential early markers for risk of aggressive PCa should be evaluated.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653		a Gene Frequency
653		a Genetic Predisposition to Disease
653		a Genetic Variation
653		a Genotype
653		a Humans
653		a Male
653		a Neoplasm Invasiveness
653		a genetics
653		a Polymorphism
653		a Single Nucleotide
653		a Prostatic Neoplasms
653		a genetics
653		a pathology
653		a Registries
653		a Sweden
653		a Tumor Markers
653		a Biological
653		a genetics
653		a United States
653		a MEDICINE
700	1	a Zheng, Siqun Lilly4 aut
700	1	a Isaacs, Sarah D4 aut
700	1	a Wiley, Kathleen E4 aut
700	1	a Wiklund, Fredriku Karolinska Institutet4 aut
700	1	a Sun, Jielin4 aut
700	1	a Kader, A Karim4 aut
700	1	a Li, Ge4 aut
700	1	a Purcell, Lina D4 aut
700	1	a Kim, Seong-Tae4 aut
700	1	a Hsu, Fang-Chi4 aut
700	1	a Stattin, Päru Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)past0003
700	1	a Hugosson, Jonas,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology4 aut0 (Swepub:gu)xhugjo
700	1	a Adolfsson, Janu Karolinska Institutet4 aut
700	1	a Walsh, Patrick C4 aut
700	1	a Trent, Jeffrey M4 aut
700	1	a Duggan, David4 aut
700	1	a Carpten, John4 aut
700	1	a Grönberg, Henriku Karolinska Institutet4 aut
700	1	a Isaacs, William B4 aut
710	2	a Karolinska Institutetb Urologi och andrologi4 org
773	0	t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 107:5, s. 2136-40q 107:5<2136-40x 1091-6490x 0027-8424
773	0	t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 107:5, s. 2136-40q 107:5<2136-40x 0027-8424
856	4	u https://europepmc.org/articles/pmc2836698?pdf=render
856	4 8	u https://gup.ub.gu.se/publication/130910
856	4 8	u https://doi.org/10.1073/pnas.0914061107
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32699
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:120011220

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