SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/319243"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/319243" > Deficiency of matur...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004054naa a2200457 4500
001oai:gup.ub.gu.se/319243
003SwePub
008240528s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:150333359
0247 a https://gup.ub.gu.se/publication/3192432 URI
0247 a https://doi.org/10.1038/s41598-022-16846-42 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1503333592 URI
040 a (SwePub)gud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wilhelmson, Anna S Ku Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xvilan
2451 0a Deficiency of mature B cells does not alter the atherogenic response to castration in male mice
264 c 2022-07-28
264 1b Springer Science and Business Media LLC,c 2022
520 a Testosterone deficiency in men is associated with increased atherosclerosis burden and increased cardiovascular risk. In male mice, testosterone deficiency induced by castration increases atherosclerosis as well as mature B cell numbers in spleen. As B cells are potentially pro-atherogenic, we hypothesized that there may be a link between these effects. To address whether mature B cell deficiency alter the atherogenic response to castration, we studied B cell-deficient mu MT and genotype control male mice on an atherosclerosis-prone Apoe(-/-) background that were castrated or sham-operated pre-pubertally and fed a high-fat diet between 8 and 16 weeks of age to accelerate atherosclerosis development. Genotype did not affect the effects of castration on body weight or weights of fat depots and there were no differences in serum cholesterol levels across the four groups. Atherosclerosis assessed by quantification of lesion area in serial sections of the aortic root was significantly increased by castration and by the mu MT mutation, with no significant interaction between genotype and surgery. In conclusion, castration evokes a similar atherogenic response in B cell-deficient mu MT and control mice. These data suggest that atherogenesis following castration is unrelated to the effects of androgens on mature B cell numbers.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a oxidation-specific epitopes
653 a atherosclerosis
653 a testosterone
653 a immunity
653 a risk
653 a Science & Technology - Other Topics
7001 a Johansson, Inger,d 1962u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xjingf
7001 a Fogelstrand, Linda,d 1974u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xsvlin
7001 a Fagman, Johan Bourghardt,d 1980u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Wallenberglaboratoriet,Institute of Clinical Sciences, Department of Surgery,Wallenberg Laboratory4 aut0 (Swepub:gu)xboujo
7001 a Arnal, J. F.4 aut
7001 a Karlsson, M. C. I.u Karolinska Institutet4 aut
7001 a Tivesten, Åsa,d 1969u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xtivas
7102 a Göteborgs universitetb Wallenberglaboratoriet4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 12:1q 12:1x 2045-2322
8564 8u https://gup.ub.gu.se/publication/319243
8564 8u https://doi.org/10.1038/s41598-022-16846-4
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:150333359

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy