Mediators of the association between parental severe mental illness and offspring neurodevelopmental problems

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Fältnamn	Indikatorer	Metadata
000		04128naa a2200469 4500
001		oai:DiVA.org:oru-54591
003		SwePub
008		170112s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:129601934
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-545912 URI
024	7	a https://doi.org/10.1016/j.annepidem.2014.05.0102 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1296019342 URI
040		a (SwePub)orud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a McCoy, Brittany M.u Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, USA4 aut
245	1 0	a Mediators of the association between parental severe mental illness and offspring neurodevelopmental problems
264	1	a New York, USA :b Elsevier,c 2014
338		a print2 rdacarrier
500		a Funding Agencies:National Institute of Child Health and Human Development National Institute of Mental Health Swedish council for working life and social research Swedish Society of Medicine
520		a Purpose: Parental severe mental illness (SMI) is associated with an increased risk of offspring autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). We conducted a study to examine the extent to which risk of preterm birth, low birth weight, and small for gestational age mediated this association.Methods: We obtained data on offspring born 1992-2001 in Sweden (n = 870,017) through the linkage of multiple population-based registers. We used logistic and Cox regression to assess the associations between parental SMI, adverse pregnancy outcomes, and offspring ASD and ADHD, as well as tested whether adverse pregnancy outcomes served as mediators.Results: After controlling for measured covariates, maternal and paternal SMI were associated with an increased risk for preterm birth, low birth weight, and gestational age, and for offspring ASD and ADHD. These pregnancy outcomes were also associated with an increased risk of ASD and ADHD. We found that pregnancy outcomes did not mediate the association between parental SMI and offspring ASD and ADHD, as there was no substantial change in magnitude of the risk estimates after controlling for pregnancy outcomes.Conclusions: Parental SMI and adverse pregnancy outcomes appear to be independent risk factors for offspring ASD and ADHD.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653		a Attention deficit hyperactivity disorder
653		a autism spectrum disorder
653		a infant
653		a small for gestational age
653		a birth weight
653		a gestational age
700	1	a Rickert, Martin E.u Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, USA4 aut
700	1	a Class, Quetzal A.u Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, USA4 aut
700	1	a Larsson, Henrik,d 1975-u Karolinska Institutet4 aut0 (Swepub:oru)hiln
700	1	a Lichtenstein, Paulu Karolinska Institutet4 aut
700	1	a D'Onofrio, Brian M.u Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, USA4 aut
710	2	a Karolinska Institutetb Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, USA4 org
773	0	t Annals of Epidemiologyd New York, USA : Elsevierg 24:9, s. 629-634.e1q 24:9<629-634.e1x 1047-2797x 1873-2585
856	4	u https://europepmc.org/articles/pmc4135008?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54591
856	4 8	u https://doi.org/10.1016/j.annepidem.2014.05.010
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:129601934

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Av författaren/redakt...: McCoy, Brittany ...; Rickert, Martin ...; Class, Quetzal A ...; Larsson, Henrik, ...; Lichtenstein, Pa ...; D'Onofrio, Brian ...

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