Sökning: WFRF:(Jonsson Magnus P.) > Novel antibodies re...
Fältnamn | Indikatorer | Metadata |
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000 | 04039naa a2200481 4500 | |
001 | oai:DiVA.org:umu-40739 | |
003 | SwePub | |
008 | 110308s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-407392 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.00115522 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Forsberg, Karinu Umeå universitet,Patologi,Thomas Brännström4 aut0 (Swepub:umu)nonkin02 |
245 | 1 0 | a Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients |
264 | c 2010-07-14 | |
264 | 1 | b Public library of science,c 2010 |
338 | a electronic2 rdacarrier | |
520 | a Mutations in CuZn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) and are found in 6% of ALS patients. Non-native and aggregation-prone forms of mutant SOD1s are thought to trigger the disease. Two sets of novel antibodies, raised in rabbits and chicken, against peptides spaced along the human SOD1 sequence, were by enzyme-linked immunosorbent assay and an immunocapture method shown to be specific for denatured SOD1. These were used to examine SOD1 in spinal cords of ALS patients lacking mutations in the enzyme. Small granular SOD1-immunoreactive inclusions were found in spinal motoneurons of all 37 sporadic and familial ALS patients studied, but only sparsely in 3 of 28 neurodegenerative and 2 of 19 non-neurological control patients. The granular inclusions were by confocal microscopy found to partly colocalize with markers for lysosomes but not with inclusions containing TAR DNA binding protein-43, ubiquitin or markers for endoplasmic reticulum, autophagosomes or mitochondria. Granular inclusions were also found in carriers of SOD1 mutations and in spinobulbar muscular atrophy (SBMA) patients and they were the major type of inclusion detected in ALS patients homozygous for the wild type-like D90A mutation. The findings suggest that SOD1 may be involved in ALS pathogenesis in patients lacking mutations in the enzyme. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
653 | a amyotrophic-lateral-sclerosis; cu/zn superoxide-dismutase; motor-neuron degeneration; molecular pathology; gene mutation; linked SOD1; mutant SOD1; mice; disease; immunoreactivity | |
653 | a MEDICINE | |
653 | a MEDICIN | |
653 | a medicin | |
653 | a Medicine | |
700 | 1 | a Jonsson, P Andreasu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)aasjon95 |
700 | 1 | a Andersen, Peter Mu Umeå universitet,Neurologi4 aut0 (Swepub:umu)pean0001 |
700 | 1 | a Bergemalm, Danielu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)dalbem99 |
700 | 1 | a Graffmo, Karin Su Umeå universitet,Patologi4 aut0 (Swepub:umu)kanerl79 |
700 | 1 | a Hultdin, Magnusu Umeå universitet,Patologi4 aut0 (Swepub:umu)magn0001 |
700 | 1 | a Jacobsson, Johanu Umeå universitet,Neurologi4 aut0 (Swepub:umu)joja0063 |
700 | 1 | a Rosquist, Rolandu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)roro0002 |
700 | 1 | a Marklund, Stefan Lu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)stma0003 |
700 | 1 | a Brännström, Thomasu Umeå universitet,Patologi4 aut0 (Swepub:umu)thbr0001 |
710 | 2 | a Umeå universitetb Patologi4 org |
773 | 0 | t PLOS ONEd : Public library of scienceg 5:7, s. e11552-q 5:7<e11552-x 1932-6203 |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:402367/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011552&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40739 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0011552 |
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