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Dna methylation sig...
Dna methylation signatures predict cytogenetic subtype and outcome in pediatric acute myeloid leukemia (Aml)
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- Krali, Olga (author)
- Uppsala universitet,Molekylär medicin
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- Palle, J, 1964- (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab,Barnneurologi/Barnonkologi,Uppsala Univ, Dept Med Sci, Mol Precis Med & Sci Life Lab, S-75237 Uppsala, Sweden.;Uppsala Univ, Dept Womens & Childrens Hlth, S-75237 Uppsala, Sweden.
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- Bäcklin, Christofer, 1983- (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin
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- Abrahamsson, J. (author)
- Queen Silvia Childrens Hosp, Dept Pediat, S-41685 Gothenburg, Sweden.
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- Norén-Nyström, U. (author)
- Umeå Univ Hosp, Dept Clin Sci, Pediat, S-90185 Umeå, Sweden.
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- Hasle, H. (author)
- Aarhus Univ Hosp, Dept Pediat, DK-8200 Aarhus, Denmark.
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- Jahnukainen, K. (author)
- Helsinki Univ Cent Hosp, Childrens Hosp, Helsinki 00290, Finland.;Univ Helsinki, Helsinki 00290, Finland.
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- Jónsson, Ó G. (author)
- Landspitali Univ Hosp, Dept Pediat, IS-101 Reykjavik, Iceland.
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- Hovland, R. (author)
- Haukeland Hosp, Ctr Med Genet & Mol Med, N-5009 Bergen, Norway.
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- Lausen, B. (author)
- Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, DK-2100 Copenhagen, Denmark.
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- Larsson, Rolf (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Klinisk immunologi
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- Palmqvist, Lars, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Univ Gothenburg, Dept Clin Chem & Transfus Med, S-41346 Gothenburg, Sweden.
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- Staffas, Anna, 1982 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Univ Gothenburg, Dept Clin Chem & Transfus Med, S-41346 Gothenburg, Sweden.
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- Zeller, B. (author)
- Oslo Univ Hosp, Div Paediat & Adolescent Med, N-0450 Oslo, Norway.
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- Nordlund, Jessica (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2021-06-10
- 2021
- English.
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In: Genes. - : MDPI AG. - 2073-4425. ; 12:6
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https://doi.org/10.3...
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Abstract
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- Pediatric acute myeloid leukemia (AML) is a heterogeneous disease composed of clinically relevant subtypes defined by recurrent cytogenetic aberrations. The majority of the aberrations used in risk grouping for treatment decisions are extensively studied, but still a large proportion of pediatric AML patients remain cytogenetically undefined and would therefore benefit from additional molecular investigation. As aberrant epigenetic regulation has been widely observed during leukemogenesis, we hypothesized that DNA methylation signatures could be used to predict molecular subtypes and identify signatures with prognostic impact in AML. To study genome-wide DNA methylation, we analyzed 123 diagnostic and 19 relapse AML samples on Illumina 450k DNA methylation arrays. We designed and validated DNA methylation-based classifiers for AML cytogenetic subtype, resulting in an overall test accuracy of 91%. Furthermore, we identified methylation signatures associated with outcome in t(8;21)/RUNX1-RUNX1T1, normal karyotype, and MLL/KMT2A-rearranged subgroups (p < 0.01). Overall, these results further underscore the clinical value of DNA methylation analysis in AML. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- 450k array
- Acute myeloid leukemia
- Classification
- DNA methylation
- Epigenetics
- Pediatric AML
- Subtyping
- mixed lineage leukemia protein
- protein CBFA2T1
- transcription factor RUNX1
- adolescent
- Article
- cancer patient
- cancer prognosis
- cancer recurrence
- child
- controlled study
- cytogenetics
- gene rearrangement
- human
- human cell
- human tissue
- karyotype
- KMT2A gene
- leukemogenesis
- major clinical study
- MLL gene
- RUNX1 gene
- RUNX1T1 gene
- tumor-related gene
- DNA methylation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Krali, Olga
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Palle, J, 1964-
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Bäcklin, Christo ...
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Abrahamsson, J.
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Norén-Nyström, U ...
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Hasle, H.
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show more...
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Jahnukainen, K.
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Jónsson, Ó G.
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Hovland, R.
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Lausen, B.
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Larsson, Rolf
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Palmqvist, Lars, ...
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Staffas, Anna, 1 ...
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Zeller, B.
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Nordlund, Jessic ...
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University of Gothenburg
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Uppsala University