Sökning: WFRF:(Hoek Hans) > Long-term low-level...
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000 | 06323naa a2200985 4500 | |
001 | oai:DiVA.org:su-190078 | |
003 | SwePub | |
008 | 210216s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:145532316 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1900782 URI |
024 | 7 | a https://doi.org/10.1016/j.envint.2020.1062492 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1455323162 URI |
040 | a (SwePub)sud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hvidtfeldt, Ulla Arthur4 aut |
245 | 1 0 | a Long-term low-level ambient air pollution exposure and risk of lung cancer - A pooled analysis of 7 European cohorts |
264 | 1 | b Elsevier BV,c 2021 |
338 | a print2 rdacarrier | |
520 | a Background/aim: Ambient air pollution has been associated with lung cancer, but the shape of the exposure-response function - especially at low exposure levels - is not well described. The aim of this study was to address the relationship between long-term low-level air pollution exposure and lung cancer incidence.Methods: The Effects of Low-level Air Pollution: a Study in Europe (ELAPSE) collaboration pools seven cohorts from across Europe. We developed hybrid models combining air pollution monitoring, land use data, satellite observations, and dispersion model estimates for nitrogen dioxide (NO2), fine particulate matter (PM2.5), black carbon (BC), and ozone (O-3) to assign exposure to cohort participants' residential addresses in 100 m by 100 m grids. We applied stratified Cox proportional hazards models, adjusting for potential confounders (age, sex, calendar year, marital status, smoking, body mass index, employment status, and neighborhood-level socioeconomic status). We fitted linear models, linear models in subsets, Shape-Constrained Health Impact Functions (SCHIF), and natural cubic spline models to assess the shape of the association between air pollution and lung cancer at concentrations below existing standards and guidelines.Results: The analyses included 307,550 cohort participants. During a mean follow-up of 18.1 years, 3956 incident lung cancer cases occurred. Median (Q1, Q3) annual (2010) exposure levels of NO2, PM2.5, BC and O-3 (warm season) were 24.2 mu g/m(3) (19.5, 29.7), 15.4 mu g/m(3) (12.8, 17.3), 1.6 10(-5)m(-1) (1.3, 1.8), and 86.6 mu g/m(3) (78.5, 92.9), respectively. We observed a higher risk for lung cancer with higher exposure to PM2.5 (HR: 1.13, 95% CI: 1.05, 1.23 per 5 mu g/m(3)). This association was robust to adjustment for other pollutants. The SCHIF, spline and subset analyses suggested a linear or supra-linear association with no evidence of a threshold. In subset analyses, risk estimates were clearly elevated for the subset of subjects with exposure below the EU limit value of 25 mu g/m(3). We did not observe associations between NO2, BC or O-3 and lung cancer incidence.Conclusions: Long-term ambient PM2.5 exposure is associated with lung cancer incidence even at concentrations below current EU limit values and possibly WHO Air Quality Guidelines. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
653 | a Air pollution | |
653 | a Lung cancer incidence | |
653 | a Particulate matter | |
653 | a Dose response relationship | |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Jovanovic Andersen, Zorana4 aut |
700 | 1 | a Atkinson, Richard4 aut |
700 | 1 | a Bauwelinck, Mariska4 aut |
700 | 1 | a Bellander, Tomu Karolinska Institutet4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Brandt, Jørgen4 aut |
700 | 1 | a Brunekreef, Bert4 aut |
700 | 1 | a Cesaroni, Giulia4 aut |
700 | 1 | a Chen, Jie4 aut |
700 | 1 | a Concin, Hans4 aut |
700 | 1 | a Forastiere, Francesco4 aut |
700 | 1 | a van Gils, Carla H.4 aut |
700 | 1 | a Gulliver, John4 aut |
700 | 1 | a Hertel, Ole4 aut |
700 | 1 | a Hoek, Gerard4 aut |
700 | 1 | a Hoffmann, Barbara4 aut |
700 | 1 | a de Hoogh, Kees4 aut |
700 | 1 | a Janssen, Nicole4 aut |
700 | 1 | a Jöckel, Karl-Heinz4 aut |
700 | 1 | a Jørgensen, Jeanette Therming4 aut |
700 | 1 | a Katsouyanni, Kleau Karolinska Institutet4 aut |
700 | 1 | a Ketzel, Matthias4 aut |
700 | 1 | a Klompmaker, Jochem O.4 aut |
700 | 1 | a Krog, Norun Hjertager4 aut |
700 | 1 | a Lang, Alois4 aut |
700 | 1 | a Leander, Karin4 aut |
700 | 1 | a Liu, Shuou Karolinska Institutet4 aut |
700 | 1 | a Ljungman, Petter L. S.4 aut |
700 | 1 | a Magnusson, Patrik K. E.4 aut |
700 | 1 | a Mehta, Amar Jayant4 aut |
700 | 1 | a Nagel, Gabriele4 aut |
700 | 1 | a Oftedal, Bente4 aut |
700 | 1 | a Pershagen, Göranu Karolinska Institutet4 aut |
700 | 1 | a Peter, Raphael Simon4 aut |
700 | 1 | a Peters, Annette4 aut |
700 | 1 | a Renzi, Matteo4 aut |
700 | 1 | a Rizzuto, Deborau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden4 aut |
700 | 1 | a Rodopoulou, Sophia4 aut |
700 | 1 | a Samoli, Evangelia4 aut |
700 | 1 | a Schwarze, Per Everhard4 aut |
700 | 1 | a Sigsgaard, Torben4 aut |
700 | 1 | a Simonsen, Mette Kildevæld4 aut |
700 | 1 | a Stafoggia, Massimo4 aut |
700 | 1 | a Strak, Maciek4 aut |
700 | 1 | a Vienneau, Danielle4 aut |
700 | 1 | a Weinmayr, Gudrun4 aut |
700 | 1 | a Wolf, Kathrin4 aut |
700 | 1 | a Raaschou-Nielsen, Ole4 aut |
700 | 1 | a Fecht, Daniela4 aut |
710 | 2 | a Karolinska Institutetb Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 org |
773 | 0 | t Environment Internationald : Elsevier BVg 146q 146x 0160-4120x 1873-6750 |
856 | 4 | u https://doi.org/10.1016/j.envint.2020.106249y Fulltext |
856 | 4 | u https://doi.org/10.1016/j.envint.2020.106249 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-190078 |
856 | 4 8 | u https://doi.org/10.1016/j.envint.2020.106249 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145532316 |
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