Association between Circulation Indole-3-Acetic Acid Levels and Stem Cell Factor in Maintenance Hemodialysis Patients: A Cross-Sectional Study

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Fältnamn	Indikatorer	Metadata
000		05174naa a2200481 4500
001		oai:DiVA.org:uu-407641
003		SwePub
008		200331s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4076412 URI
024	7	a https://doi.org/10.3390/jcm90101242 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Wu, Ping-Hsunu Uppsala universitet,Endokrinologi och mineralmetabolism,Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan4 aut0 (Swepub:uu)pinwu324
245	1 0	a Association between Circulation Indole-3-Acetic Acid Levels and Stem Cell Factor in Maintenance Hemodialysis Patients :b A Cross-Sectional Study
264		c 2020-01-02
264	1	b MDPI,c 2020
338		a electronic2 rdacarrier
520		a Protein-bound uremic toxin is a cardiovascular (CV) risk factor for patients with end-stage renal disease. Indole-3-acetic acid (IAA) was found to be associated with CV disease but the detailed pathophysiology remains unknown. Moreover, mitogen-activated protein kinase (MAPK) signaling cascades play an important role in the pathogenesis of CV disease. Thus, we explored the association between circulating IAA levels and forty MAPK cascade associated proteins in patients undergoing hemodialysis (HD). Circulating total form IAA was quantified by mass spectrometry and forty MAPK cascade associated proteins by a proximity extension assay in 331 prevalent HD patients. Accounting for multiple testing, and in multivariable-adjusted linear regression models, circulating total form IAA levels were positively associated with stem cell factor (beta coefficient 0.13, 95% confidence interval 0.04 to 0.21, p = 0.004). A bioinformatics approach using the search tool for interactions of chemicals (STITCH) tool provided information that IAA may be involved in the regulation of cell proliferation, hematopoietic cells, and the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. The knowledge gained here can be generalized, thereby impacting the non-traditional CV risk factors in patients with kidney disease. Further in vitro work is necessary to validate the translation of the mechanistic pathways.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653		a uremic toxins
653		a indole-3-acetic acid
653		a proteomics
653		a mitogen-activated protein kinase cascade proteins
653		a hemodialysis
700	1	a Yi-Ting, Linu Uppsala universitet,Institutionen för medicinska vetenskaper,Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 807, Taiwan4 aut0 (Swepub:uu)yitli615
700	1	a Wu, Pei-Yuu Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Lab Med, Kaohsiung 807, Taiwan4 aut
700	1	a Lee, Hei-Hwau Kaohsiung Med Univ Hosp, Dept Lab Med, Kaohsiung 807, Taiwan4 aut
700	1	a Lee, Su-Chuu Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan4 aut
700	1	a Hung, Szu-Chunu Tzu Chi Univ, Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Div Nephrol, Hualien 23142, Taiwan;Tzu Chi Univ, Sch Med, Hualien 23142, Taiwan4 aut
700	1	a Chen, Szu-Chiau Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 81267, Taiwan4 aut
700	1	a Kuo, Mei-Chuanu Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung 807, Taiwan4 aut
700	1	a Chiu, Yi-Wenu Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung 807, Taiwan4 aut
710	2	a Uppsala universitetb Endokrinologi och mineralmetabolism4 org
773	0	t Journal of Clinical Medicined : MDPIg 9:1q 9:1x 2077-0383
856	4	u https://doi.org/10.3390/jcm9010124y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1420603/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.mdpi.com/2077-0383/9/1/124/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407641
856	4 8	u https://doi.org/10.3390/jcm9010124

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Av författaren/redakt...: Wu, Ping-Hsun; Yi-Ting, Lin; Wu, Pei-Yu; Lee, Hei-Hwa; Lee, Su-Chu; Hung, Szu-Chun; visa fler...; Chen, Szu-Chia; Kuo, Mei-Chuan; Chiu, Yi-Wen; visa färre...

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