Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Van Duijnhoven Franzel J. B.) > Genetic risk impact...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		20312naa a2201261 4500
001		oai:DiVA.org:umu-223079
003		SwePub
008		240417s2024 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:155394224
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2230792 URI
024	7	a https://doi.org/10.1038/s41416-024-02638-22 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1553942242 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Tian, Yuu School of Public Health, Capital Medical University, Beijing, China; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
245	1 0	a Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
264	1	b Springer Nature,c 2024
338		a electronic2 rdacarrier
520		a Background: Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT risk-benefit assessment, we aimed to evaluate the joint association of a polygenic risk score (PRS) for CRC and MHT on CRC risk.Methods: We used data from 28,486 postmenopausal women (11,519 cases and 16,967 controls) of European descent. A PRS based on 141 CRC-associated genetic variants was modeled as a categorical variable in quartiles. Multiplicative interaction between PRS and MHT use was evaluated using logistic regression. Additive interaction was measured using the relative excess risk due to interaction (RERI). 30-year cumulative risks of CRC for 50-year-old women according to MHT use and PRS were calculated.Results: The reduction in odds ratios by MHT use was larger in women within the highest quartile of PRS compared to that in women within the lowest quartile of PRS (p-value = 2.7 × 10−8). At the highest quartile of PRS, the 30-year CRC risk was statistically significantly lower for women taking any MHT than for women not taking any MHT, 3.7% (3.3%–4.0%) vs 6.1% (5.7%–6.5%) (difference 2.4%, P-value = 1.83 × 10−14); these differences were also statistically significant but smaller in magnitude in the lowest PRS quartile, 1.6% (1.4%–1.8%) vs 2.2% (1.9%–2.4%) (difference 0.6%, P-value = 1.01 × 10−3), indicating 4 times greater reduction in absolute risk associated with any MHT use in the highest compared to the lowest quartile of genetic CRC risk.Conclusions: MHT use has a greater impact on the reduction of CRC risk for women at higher genetic risk. These findings have implications for the development of risk prediction models for CRC and potentially for the consideration of genetic information in the risk-benefit assessment of MHT use.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Lin, Yiu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Qu, Conghuiu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Arndt, Volkeru Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
700	1	a Baurley, James W.u Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; BioRealm LLC, CA, Walnut, United States4 aut
700	1	a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States4 aut
700	1	a Bien, Stephanie A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Bishop, D. Timothyu Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom4 aut
700	1	a Brenner, Hermannu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
700	1	a Buchanan, Daniel D.u Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, VIC, Parkville, Australia4 aut
700	1	a Budiarto, Arifu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut
700	1	a Campbell, Peter T.u Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States4 aut
700	1	a Carreras-Torres, Robertu Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute Dr Josep Trueta (IDIBGI), Girona, Salt, Spain4 aut
700	1	a Casey, Grahamu Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States4 aut
700	1	a Chan, Andrew T.u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States4 aut
700	1	a Chen, Ruiu School of Public Health, Capital Medical University, Beijing, China4 aut
700	1	a Chen, Xuechenu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
700	1	a Conti, David V.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Díez-Obrero, Virginiau Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
700	1	a Dimou, Nikiu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut
700	1	a Drew, David A.u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States4 aut
700	1	a Figueiredo, Jane C.u Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Gallinger, Stevenu Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada4 aut
700	1	a Giles, Graham G.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia4 aut
700	1	a Gruber, Stephen B.u Department of Medical Oncology & amp; Therapeutics Research, City of Hope National Medical Center, CA, Duarte, United States4 aut
700	1	a Gunter, Marc J.u Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut
700	1	a Harlid, Sophia,d 1978-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)soha0105
700	1	a Harrison, Tabitha A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Hidaka, Akihisau Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Hoffmeister, Michaelu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
700	1	a Huyghe, Jeroen R.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700	1	a Jenkins, Mark A.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia4 aut
700	1	a Jordahl, Kristina M.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut
700	1	a Joshi, Amit D.u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States4 aut
700	1	a Keku, Temitope O.u Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States4 aut
700	1	a Kawaguchi, Ericu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Kim, Andre E.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Kundaje, Anshulu Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States4 aut
700	1	a Larsson, Susanna C.u Karolinska Institutet4 aut
700	1	a Marchand, Loic Leu University of Hawaii Cancer Center, HI, Honolulu, United States4 aut
700	1	a Lewinger, Juan Pablou Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Li, Liu Department of Family Medicine, University of Virginia, VA, Charlottesville, United States4 aut
700	1	a Moreno, Victoru Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L’Hospitalet de Llobregat, Barcelona, Spain4 aut
700	1	a Morrison, Johnu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Murphy, Neilu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut
700	1	a Nan, Hongmeiu Department of Global Health, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indianapolis, IN, Indianapolis, United States4 aut
700	1	a Nassir, Ramiu Department of Pathology, School of Medicine, Umm Al-Qura’a University, Mecca, Saudi Arabia4 aut
700	1	a Newcomb, Polly A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut
700	1	a Obón-Santacana, Mireiau Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
700	1	a Ogino, Shujiu Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Tokyo Medical and Dental University (Institute of Science Tokyo), Tokyo, Japan4 aut
700	1	a Ose, Jenniferu Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States; Hochschule Hannover, University of Applied Sciences and Arts, Department III: Media, Information and Design, Hannover, Germany4 aut
700	1	a Pardamean, Bensu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut
700	1	a Pellatt, Andrew J.u Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, TX, Houston, United States4 aut
700	1	a Peoples, Anita R.u Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut
700	1	a Platz, Elizabeth A.u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States4 aut
700	1	a Potter, John D.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand4 aut
700	1	a Prentice, Ross L.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States4 aut
700	1	a Rennert, Gadu Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel4 aut
700	1	a Ruiz-Narvaez, Edward A.u Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States4 aut
700	1	a Sakoda, Lori C.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States4 aut
700	1	a Schoen, Robert E.u Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States4 aut
700	1	a Shcherbina, Annau Biomedical Informatics Program, Department of Biomedical Data Sciences, Stanford University, CA, Stanford, United States4 aut
700	1	a Stern, Mariana C.u Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Su, Yu-Ruu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States4 aut
700	1	a Thibodeau, Stephen N.u Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States4 aut
700	1	a Thomas, Duncan C.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Tsilidis, Konstantinos K.u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece4 aut
700	1	a van Duijnhoven, Franzel J. B.u Division of Human Nutrition and Health, Wageningen University & amp; Research, Wageningen, Netherlands4 aut
700	1	a van Guelpen, Bethanyu Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi4 aut0 (Swepub:umu)beyvan99
700	1	a Visvanathan, Kalau Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States4 aut
700	1	a White, Emilyu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut
700	1	a Wolk, Alicjau Karolinska Institutet4 aut
700	1	a Woods, Michael O.u Memorial University of Newfoundland, Discipline of Genetics, NL, St. John’s, Canada4 aut
700	1	a Wu, Anna H.u Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Peters, Ulrikeu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut
700	1	a Gauderman, W. Jamesu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700	1	a Hsu, Liu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States4 aut
700	1	a Chang-Claude, Jennyu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Cancer Centre Hamburg (UCCH), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany4 aut
710	2	a School of Public Health, Capital Medical University, Beijing, China; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germanyb Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 org
773	0	t British Journal of Cancerd : Springer Natureg 130:10, s. 1687-1696q 130:10<1687-1696x 0007-0920x 1532-1827
856	4	u https://doi.org/10.1038/s41416-024-02638-2y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1852222/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223079
856	4 8	u https://doi.org/10.1038/s41416-024-02638-2
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:155394224

Hitta via bibliotek

British Journal of Cancer (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Tian, Yu; Lin, Yi; Qu, Conghui; Arndt, Volker; Baurley, James W ...; Berndt, Sonja I.; visa fler...; Bien, Stephanie ...; Bishop, D. Timot ...; Brenner, Hermann; Buchanan, Daniel ...; Budiarto, Arif; Campbell, Peter ...; Carreras-Torres, ...; Casey, Graham; Chan, Andrew T.; Chen, Rui; Chen, Xuechen; Conti, David V.; Díez-Obrero, Vir ...; Dimou, Niki; Drew, David A.; Figueiredo, Jane ...; Gallinger, Steve ...; Giles, Graham G.; Gruber, Stephen ...; Gunter, Marc J.; Harlid, Sophia, ...; Harrison, Tabith ...; Hidaka, Akihisa; Hoffmeister, Mic ...; Huyghe, Jeroen R ...; Jenkins, Mark A.; Jordahl, Kristin ...; Joshi, Amit D.; Keku, Temitope O ...; Kawaguchi, Eric; Kim, Andre E.; Kundaje, Anshul; Larsson, Susanna ...; Marchand, Loic L ...; Lewinger, Juan P ...; Li, Li; Moreno, Victor; Morrison, John; Murphy, Neil; Nan, Hongmei; Nassir, Rami; Newcomb, Polly A ...; Obón-Santacana, ...; Ogino, Shuji; Ose, Jennifer; Pardamean, Bens; Pellatt, Andrew ...; Peoples, Anita R ...; Platz, Elizabeth ...; Potter, John D.; Prentice, Ross L ...; Rennert, Gad; Ruiz-Narvaez, Ed ...; Sakoda, Lori C.; Schoen, Robert E ...; Shcherbina, Anna; Stern, Mariana C ...; Su, Yu-Ru; Thibodeau, Steph ...; Thomas, Duncan C ...; Tsilidis, Konsta ...; van Duijnhoven, ...; van Guelpen, Bet ...; Visvanathan, Kal ...; White, Emily; Wolk, Alicja; Woods, Michael O ...; Wu, Anna H.; Peters, Ulrike; Gauderman, W. Ja ...; Hsu, Li; Chang-Claude, Je ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: British Journal ...

Av lärosätet: Umeå universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se