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  • Levine, David M (author)

A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-10-13
  • Springer Science and Business Media LLC,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-273753
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273753URI
  • https://doi.org/10.1038/ng.2796DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127920472URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Esophageal adenocarcinoma is a cancer with rising incidence and poor survival. Most such cancers arise in a specialized intestinal metaplastic epithelium, which is diagnostic of Barrett's esophagus. In a genome-wide association study, we compared esophageal adenocarcinoma cases (n = 2,390) and individuals with precancerous Barrett's esophagus (n = 3,175) with 10,120 controls in 2 phases. For the combined case group, we identified three new associations. The first is at 19p13 (rs10419226: P = 3.6 × 10(-10)) in CRTC1 (encoding CREB-regulated transcription coactivator), whose aberrant activation has been associated with oncogenic activity. A second is at 9q22 (rs11789015: P = 1.0 × 10(-9)) in BARX1, which encodes a transcription factor important in esophageal specification. A third is at 3p14 (rs2687201: P = 5.5 × 10(-9)) near the transcription factor FOXP1, which regulates esophageal development. We also refine a previously reported association with Barrett's esophagus near the putative tumor suppressor gene FOXF1 at 16q24 and extend our findings to now include esophageal adenocarcinoma.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ek, Weronica E (author)
  • Zhang, Rui (author)
  • Liu, Xinxue (author)
  • Onstad, Lynn (author)
  • Sather, Cassandra (author)
  • Lao-Sirieix, Pierre (author)
  • Gammon, Marilie D (author)
  • Corley, Douglas A (author)
  • Shaheen, Nicholas J (author)
  • Bird, Nigel C (author)
  • Hardie, Laura J (author)
  • Murray, Liam J (author)
  • Reid, Brian J (author)
  • Chow, Wong-Ho (author)
  • Risch, Harvey A (author)
  • Nyrén, Olof (author)
  • Ye, WeiminKarolinska Institutet (author)
  • Liu, Geoffrey (author)
  • Romero, Yvonne (author)
  • Bernstein, Leslie (author)
  • Wu, Anna H (author)
  • Casson, Alan G (author)
  • Chanock, Stephen J (author)
  • Harrington, Patricia (author)
  • Caldas, Isabel (author)
  • Debiram-Beecham, Irene (author)
  • Caldas, Carlos (author)
  • Hayward, Nicholas K (author)
  • Pharoah, Paul D (author)
  • Fitzgerald, Rebecca C (author)
  • Macgregor, Stuart (author)
  • Whiteman, David C (author)
  • Vaughan, Thomas L (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC45:121061-40361546-1718

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