A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.

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Fältnamn	Indikatorer	Metadata
000		04122naa a2200757 4500
001		oai:DiVA.org:uu-273753
003		SwePub
008		160118s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:127920472
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2737532 URI
024	7	a https://doi.org/10.1038/ng.27962 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1279204722 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Levine, David M4 aut
245	1 0	a A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
264		c 2013-10-13
264	1	b Springer Science and Business Media LLC,c 2013
338		a print2 rdacarrier
520		a Esophageal adenocarcinoma is a cancer with rising incidence and poor survival. Most such cancers arise in a specialized intestinal metaplastic epithelium, which is diagnostic of Barrett's esophagus. In a genome-wide association study, we compared esophageal adenocarcinoma cases (n = 2,390) and individuals with precancerous Barrett's esophagus (n = 3,175) with 10,120 controls in 2 phases. For the combined case group, we identified three new associations. The first is at 19p13 (rs10419226: P = 3.6 × 10(-10)) in CRTC1 (encoding CREB-regulated transcription coactivator), whose aberrant activation has been associated with oncogenic activity. A second is at 9q22 (rs11789015: P = 1.0 × 10(-9)) in BARX1, which encodes a transcription factor important in esophageal specification. A third is at 3p14 (rs2687201: P = 5.5 × 10(-9)) near the transcription factor FOXP1, which regulates esophageal development. We also refine a previously reported association with Barrett's esophagus near the putative tumor suppressor gene FOXF1 at 16q24 and extend our findings to now include esophageal adenocarcinoma.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Ek, Weronica E4 aut
700	1	a Zhang, Rui4 aut
700	1	a Liu, Xinxue4 aut
700	1	a Onstad, Lynn4 aut
700	1	a Sather, Cassandra4 aut
700	1	a Lao-Sirieix, Pierre4 aut
700	1	a Gammon, Marilie D4 aut
700	1	a Corley, Douglas A4 aut
700	1	a Shaheen, Nicholas J4 aut
700	1	a Bird, Nigel C4 aut
700	1	a Hardie, Laura J4 aut
700	1	a Murray, Liam J4 aut
700	1	a Reid, Brian J4 aut
700	1	a Chow, Wong-Ho4 aut
700	1	a Risch, Harvey A4 aut
700	1	a Nyrén, Olof4 aut
700	1	a Ye, Weiminu Karolinska Institutet4 aut
700	1	a Liu, Geoffrey4 aut
700	1	a Romero, Yvonne4 aut
700	1	a Bernstein, Leslie4 aut
700	1	a Wu, Anna H4 aut
700	1	a Casson, Alan G4 aut
700	1	a Chanock, Stephen J4 aut
700	1	a Harrington, Patricia4 aut
700	1	a Caldas, Isabel4 aut
700	1	a Debiram-Beecham, Irene4 aut
700	1	a Caldas, Carlos4 aut
700	1	a Hayward, Nicholas K4 aut
700	1	a Pharoah, Paul D4 aut
700	1	a Fitzgerald, Rebecca C4 aut
700	1	a Macgregor, Stuart4 aut
700	1	a Whiteman, David C4 aut
700	1	a Vaughan, Thomas L4 aut
710	2	a Karolinska Institutet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 45:12q 45:12x 1061-4036x 1546-1718
856	4	u https://europepmc.org/articles/pmc3840115?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273753
856	4 8	u https://doi.org/10.1038/ng.2796
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:127920472

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