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WFRF:(Knol Edward F)
 

Sökning: WFRF:(Knol Edward F) > (2020-2023) > Immune modulation v...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005582naa a2200625 4500
001oai:lup.lub.lu.se:30bd529f-3345-4102-ac33-fb4957b3e39a
003SwePub
008210114s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/30bd529f-3345-4102-ac33-fb4957b3e39a2 URI
0247 a https://doi.org/10.1111/all.144782 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Roth-Walter, Franziskau University of Veterinary Medicine Vienna4 aut
2451 0a Immune modulation via T regulatory cell enhancement : Disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases—An EAACI position paper of the Task Force on Immunopharmacology (TIPCO)
264 c 2021-01-07
264 1b Wiley,c 2021
300 a 24 s.
520 a Therapeutic advances using targeted biologicals and small-molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune, and inflammatory diseases particularly for some patients with severe, treatment-resistant forms. This has been aided by improved identification of disease phenotypes. Despite these achievements, not all severe forms of chronic inflammatory and autoimmune diseases are successfully targeted, and current treatment options, besides allergen immunotherapy for selected allergic diseases, fail to change the disease course. T cell–based therapies aim to cure diseases through the selective induction of appropriate immune responses following the delivery of engineered, specific cytotoxic, or regulatory T cells (Tregs). Adoptive cell therapies (ACT) with genetically engineered T cells have revolutionized the oncology field, bringing curative treatment for leukemia and lymphoma, while therapies exploiting the suppressive functions of Tregs have been developed in nononcological settings, such as in transplantation and autoimmune diseases. ACT with Tregs are also being considered in nononcological settings such as cardiovascular disease, obesity, and chronic inflammatory disorders. After describing the general features of T cell–based approaches and current applications in autoimmune diseases, this position paper reviews the experimental models testing or supporting T cell–based approaches, especially Treg-based approaches, in severe IgE-mediated responses and chronic respiratory airway diseases, such as severe asthma and COPD. Along with an assessment of challenges and unmet needs facing the application of ACT in these settings, this article underscores the potential of ACT to offer curative options for patients with severe or treatment-resistant forms of these immune-driven disorders.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a adoptive cell therapies
653 a allergy
653 a autoimmunity
653 a CAR-Treg cells
653 a immunoregulation
7001 a Adcock, Ian M.u Imperial College London4 aut
7001 a Benito-Villalvilla, Cristinau Complutense University of Madrid4 aut
7001 a Bianchini, Rodolfou University of Veterinary Medicine Vienna4 aut
7001 a Bjermer, Leifu Lund University,Lunds universitet,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Clinical Respiratory Medicine,Lund University Research Groups4 aut0 (Swepub:lu)lung-lbj
7001 a Boyman, Onuru University of Zurich,University Hospital of Zurich4 aut
7001 a Caramori, Gaetanou University of Messina4 aut
7001 a Cari, Luigiu University of Perugia4 aut
7001 a Fan Chung, Kianu Royal Brompton and Harefield NHS Foundation Trust,Imperial College London4 aut
7001 a Diamant, Zuzanau QPS-Netherlands,University Medical Center Groningen,Skåne University Hospital,Thomayer Hospital,Charles University in Prague,University of Groningen4 aut0 (Swepub:lu)med-zdt
7001 a Eguiluz-Gracia, Ibonu Hospital Regional de Málaga4 aut
7001 a Knol, Edward F.u University Medical Center Utrecht4 aut
7001 a Kolios, Antoniosu University Hospital of Zurich,University of Zurich4 aut
7001 a Levi-Schaffer, Francescau Hebrew University of Jerusalem4 aut
7001 a Nocentini, Giuseppeu University of Perugia4 aut
7001 a Palomares, Oscaru Complutense University of Madrid4 aut
7001 a Redegeld, Franku Utrecht University4 aut
7001 a Van Esch, Bettyu Utrecht University4 aut
7001 a Stellato, Cristianau University of Salerno4 aut
7102 a University of Veterinary Medicine Viennab Imperial College London4 org
7730 t Allergy: European Journal of Allergy and Clinical Immunologyd : Wileyg 76:1, s. 90-113q 76:1<90-113x 0105-4538
7730 t Allergyd : Wileyg 76:1, s. 90-113q 76:1<90-113x 1398-9995
8564 u http://dx.doi.org/10.1111/all.14478y FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14478
8564 8u https://lup.lub.lu.se/record/30bd529f-3345-4102-ac33-fb4957b3e39a
8564 8u https://doi.org/10.1111/all.14478

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