Sökning: WFRF:(Knol Edward F) > (2020-2023) > Immune modulation v...
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000 | 05582naa a2200625 4500 | |
001 | oai:lup.lub.lu.se:30bd529f-3345-4102-ac33-fb4957b3e39a | |
003 | SwePub | |
008 | 210114s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/30bd529f-3345-4102-ac33-fb4957b3e39a2 URI |
024 | 7 | a https://doi.org/10.1111/all.144782 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Roth-Walter, Franziskau University of Veterinary Medicine Vienna4 aut |
245 | 1 0 | a Immune modulation via T regulatory cell enhancement : Disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases—An EAACI position paper of the Task Force on Immunopharmacology (TIPCO) |
264 | c 2021-01-07 | |
264 | 1 | b Wiley,c 2021 |
300 | a 24 s. | |
520 | a Therapeutic advances using targeted biologicals and small-molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune, and inflammatory diseases particularly for some patients with severe, treatment-resistant forms. This has been aided by improved identification of disease phenotypes. Despite these achievements, not all severe forms of chronic inflammatory and autoimmune diseases are successfully targeted, and current treatment options, besides allergen immunotherapy for selected allergic diseases, fail to change the disease course. T cell–based therapies aim to cure diseases through the selective induction of appropriate immune responses following the delivery of engineered, specific cytotoxic, or regulatory T cells (Tregs). Adoptive cell therapies (ACT) with genetically engineered T cells have revolutionized the oncology field, bringing curative treatment for leukemia and lymphoma, while therapies exploiting the suppressive functions of Tregs have been developed in nononcological settings, such as in transplantation and autoimmune diseases. ACT with Tregs are also being considered in nononcological settings such as cardiovascular disease, obesity, and chronic inflammatory disorders. After describing the general features of T cell–based approaches and current applications in autoimmune diseases, this position paper reviews the experimental models testing or supporting T cell–based approaches, especially Treg-based approaches, in severe IgE-mediated responses and chronic respiratory airway diseases, such as severe asthma and COPD. Along with an assessment of challenges and unmet needs facing the application of ACT in these settings, this article underscores the potential of ACT to offer curative options for patients with severe or treatment-resistant forms of these immune-driven disorders. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a adoptive cell therapies | |
653 | a allergy | |
653 | a autoimmunity | |
653 | a CAR-Treg cells | |
653 | a immunoregulation | |
700 | 1 | a Adcock, Ian M.u Imperial College London4 aut |
700 | 1 | a Benito-Villalvilla, Cristinau Complutense University of Madrid4 aut |
700 | 1 | a Bianchini, Rodolfou University of Veterinary Medicine Vienna4 aut |
700 | 1 | a Bjermer, Leifu Lund University,Lunds universitet,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Clinical Respiratory Medicine,Lund University Research Groups4 aut0 (Swepub:lu)lung-lbj |
700 | 1 | a Boyman, Onuru University of Zurich,University Hospital of Zurich4 aut |
700 | 1 | a Caramori, Gaetanou University of Messina4 aut |
700 | 1 | a Cari, Luigiu University of Perugia4 aut |
700 | 1 | a Fan Chung, Kianu Royal Brompton and Harefield NHS Foundation Trust,Imperial College London4 aut |
700 | 1 | a Diamant, Zuzanau QPS-Netherlands,University Medical Center Groningen,Skåne University Hospital,Thomayer Hospital,Charles University in Prague,University of Groningen4 aut0 (Swepub:lu)med-zdt |
700 | 1 | a Eguiluz-Gracia, Ibonu Hospital Regional de Málaga4 aut |
700 | 1 | a Knol, Edward F.u University Medical Center Utrecht4 aut |
700 | 1 | a Kolios, Antoniosu University Hospital of Zurich,University of Zurich4 aut |
700 | 1 | a Levi-Schaffer, Francescau Hebrew University of Jerusalem4 aut |
700 | 1 | a Nocentini, Giuseppeu University of Perugia4 aut |
700 | 1 | a Palomares, Oscaru Complutense University of Madrid4 aut |
700 | 1 | a Redegeld, Franku Utrecht University4 aut |
700 | 1 | a Van Esch, Bettyu Utrecht University4 aut |
700 | 1 | a Stellato, Cristianau University of Salerno4 aut |
710 | 2 | a University of Veterinary Medicine Viennab Imperial College London4 org |
773 | 0 | t Allergy: European Journal of Allergy and Clinical Immunologyd : Wileyg 76:1, s. 90-113q 76:1<90-113x 0105-4538 |
773 | 0 | t Allergyd : Wileyg 76:1, s. 90-113q 76:1<90-113x 1398-9995 |
856 | 4 | u http://dx.doi.org/10.1111/all.14478y FULLTEXT |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14478 |
856 | 4 8 | u https://lup.lub.lu.se/record/30bd529f-3345-4102-ac33-fb4957b3e39a |
856 | 4 8 | u https://doi.org/10.1111/all.14478 |
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