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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008549naa a2200961 4500
001oai:DiVA.org:uu-117767
003SwePub
008100222s2009 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-31020
009oai:lup.lub.lu.se:e4f7e135-9beb-4ba3-bd8f-5aa4c4f8d177
009oai:prod.swepub.kib.ki.se:119553608
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1177672 URI
0247 a https://doi.org/10.1038/ng.4682 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-310202 URI
0247 a https://lup.lub.lu.se/record/15049522 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1195536082 URI
040 a (SwePub)uud (SwePub)umud (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gateva, Veselau Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut
2451 0a A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
264 c 2009-10-18
264 1b Springer Science and Business Media LLC,c 2009
338 a print2 rdacarrier
500 a De två första författarna delar förstaförfattarskapet
520 a Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). We identified 21 additional candidate loci with P< or = 1 x 10(-5). A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P < 1 x 10(-3)) that may contribute to SLE: IFIH1, CFB, CLEC16A, IL12B and SH2B3. These results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a type I IFN system
653 a autoimmunity
653 a lupus
653 a SLE
653 a risk genes
653 a MEDICINE
653 a MEDICIN
653 a Medicin
653 a Medicine
7001 a Sandling, Johanna K.u Uppsala universitet,Molekylär medicin,Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)josan062
7001 a Hom, Geoffu Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut
7001 a Taylor, Kimberly E.u Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA4 aut
7001 a Chung, Sharon A.u Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA4 aut
7001 a Sun, Xinu Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut
7001 a Ortmann, Wardu Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut
7001 a Kosoy, Romanu Rowe Program in Genetics, University of California at Davis, Davis, California, USA4 aut
7001 a Ferreira, Ricardo C.u Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut
7001 a Nordmark, Gunnelu Uppsala universitet,Institutionen för medicinska vetenskaper,Rheumatology, Systemic Autoimmmune Diseases,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)gunnnord
7001 a Gunnarsson, Ivau Karolinska Institutet4 aut
7001 a Svenungsson, Elisabetu Karolinska Institutet4 aut
7001 a Padyukov, Leonidu Karolinska Institutet4 aut
7001 a Sturfelt, Gunnaru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-gst
7001 a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-ajo
7001 a Bengtsson, Andersu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-abe
7001 a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
7001 a Baechler, Emily C.u Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA4 aut
7001 a Brown, Elizabeth E.u University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut
7001 a Alarcón, Graciela S.u University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut
7001 a Edberg, Jeffrey C.u University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut
7001 a Ramsey-Goldman, Rosalindu Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA4 aut
7001 a McGwin, Geraldu University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut
7001 a Reveille, John D.u University of Texas–Houston Health Science Center, Houston, Texas, USA4 aut
7001 a Vilá, Luis M.u University of Puerto Rico Medical Science Campus, San Juan, Puerto Rico4 aut
7001 a Kimberly, Robert P.u University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut
7001 a Manzi, Susanu University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA4 aut
7001 a Petri, Michelle A.u Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA4 aut
7001 a Lee, Annetteu The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, New York, USA4 aut
7001 a Gregersen, Peter K.u The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, New York, USA4 aut
7001 a Seldin, Michael F.u Rowe Program in Genetics, University of California at Davis, Davis, California, USA4 aut
7001 a Rönnblom, Larsu Uppsala universitet,Institutionen för medicinska vetenskaper,Rheumatology, Systemic Autoimmmune Diseases,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)larsronn
7001 a Criswell, Lindsey A.u Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA4 aut
7001 a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin,Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)anncsyva
7001 a Behrens, Timothy W.u Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut
7001 a Graham, Robert R.u Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut
7102 a Immunology Biomarkers Group, Genentech, South San Francisco, California, USAb Molekylär medicin4 org
7730 t Nature Geneticsd : Springer Science and Business Media LLCg 41:11, s. 1228-1233q 41:11<1228-1233x 1061-4036x 1546-1718
8564 u https://europepmc.org/articles/pmc2925843?pdf=render
8564 u http://dx.doi.org/10.1038/ng.468y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-117767
8564 8u https://doi.org/10.1038/ng.468
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31020
8564 8u https://lup.lub.lu.se/record/1504952
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:119553608

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