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Global Effect of Mo...
Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality
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- Magnussen, Christina (författare)
- Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany
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- Ojeda, Francisco M. (författare)
- Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany
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- Leong, Darryl P. (författare)
- McMaster Univ, Dept Med Cardiol, Hamilton, ON, Canada
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Alegre-Diaz, Jesus (författare)
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- Amouyel, Philippe (författare)
- Univ Lille, INSERM, Ctr Hosp Univ Lille,Epidemiol & Public Hlth Dept, Inst Pasteur Lille,UMR1167 RID AGE Risk Factors &, Lille, France
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- Aviles-Santa, Larissa (författare)
- Natl Inst Minor Hlth & Hlth Dispar, Div Clin & Hlth Serv Res, NIH, Bethesda, MD USA
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- De Bacquer, Dirk (författare)
- Univ Ghent, Dept Publ Hlth & Primary Care, Ghent, Belgium
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- Ballantyne, Christie M. (författare)
- Baylor Coll Med, Dept Med, Houston, TX USA
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- Bernabé-Ortiz, Antonio (författare)
- Univ Peruana Cayetano Heredia, CRONICAS Ctr Excellence Chron Dis, Lima, Peru
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- Bobak, Martin (författare)
- UCL, Dept Epidemiol & Publ Hlth, London, England
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- Brenner, Hermann (författare)
- Heidelberg Univ, Network Aging Res, Heidelberg, Germany
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- Carrillo-Larco, Rodrigo M. (författare)
- Emory Univ, Rollins Sch Publ Hlth, Emory Global Diabet Res Ctr, Atlanta, GA USA;Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA USA
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- de Lemos, James (författare)
- Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX USA;Univ Nacl Autonoma Mexico, Expt Med Res Unit, Sch Med, Mexico City, DF, Mexico
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- Dobson, Annette (författare)
- Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia
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- Dörr, Marcus (författare)
- Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany;Greifswald Medical School; DZHK Partner Site Greifswald, Greifswald, Germany
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- Donfrancesco, Chiara (författare)
- Ist Super Sanita, Dept Cardiovasc & Endocrine Metab Dis & Aging, Rome, Italy
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- Drygas, Wojciech (författare)
- Natl Inst Cardiol, Dept Epidemiol Cardiovasc Dis Prevent & Hlth Prom, Warsaw, Poland;Lazarski Univ, Warsaw, Poland
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- Dullaart, Robin P. (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands
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- Engström, Gunnar (författare)
- Lund Univ, Dept Clin Sci Malmö, Malmö, Sweden
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- Ferrario, Marco M. (författare)
- Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med, Varese, Italy
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- Ferrières, Jean (författare)
- Toulouse Rangueil Univ Hosp, INSERM, UMR1295, Dept Cardiol, Toulouse, France
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- de Gaetano, Giovanni (författare)
- IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy
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- Goldbourt, Uri (författare)
- Tel Aviv Univ, Dept Epidemiol, Sch Publ Hlth, Tel Aviv, Israel
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- Gonzalez, Clicerio (författare)
- Inst Nacl Salud Publ, Ctr Estudios Diabet, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico
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- Grassi, Guido (författare)
- Univ Milano Bicocca, Med Clin, Milan, Italy
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- Hodge, Allison M. (författare)
- Canc Council Victoria, Div Canc Epidemiol, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia
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- Hveem, Kristian (författare)
- Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, HUNT Trondelag Hlth Study Res Ctr, Levanger, Norway;KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway
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- Iacoviello, Licia (författare)
- Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med, Varese, Italy;IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy
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- Ikram, M. Kamran (författare)
- Erasmus MC, Dept Neurol, Rotterdam, Netherlands;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
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- Irazola, Vilma (författare)
- Inst Clin Effectiveness & Hlth Policy, Dept Chron Dis, Buenos Aires, DF, Argentina
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- Jobe, Modou (författare)
- London Sch Hyg & Trop Med, Med Res Council Unit Gambia, Banjul, Gambia
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- Jousilahti, Pekka (författare)
- Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
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- Kaleebu, Pontiano (författare)
- Uganda Virus Res Inst, Med Res Council, Entebbe, Uganda;London Sch Hyg & Trop Med, Uganda Res Unit, Entebbe, Uganda
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- Kavousi, Maryam (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
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- Kee, Frank (författare)
- Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland
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- Khalili, Davood (författare)
- Shahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Res Inst Endocrine Sci, Tehran, Iran
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- Koenig, Wolfgang (författare)
- German Heart Ctr, DZHK Partner Site Munich Heart Alliance, Munich, Germany;Tech Univ Munich, Munich, Germany:Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany
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- Kontsevaya, Anna (författare)
- Minist Healthcare Russian Federat, Natl Res Ctr Therapy & Prevent Med, Moscow, Russia
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- Kuulasmaa, Kari (författare)
- Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
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- Lackner, Karl J. (författare)
- Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Clin Chem & Lab Med, Mainz, Germany;DZHK Partner Site Rhine Main, Mainz, Germany
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- Leistner, David M. (författare)
- Univ Heart & Vasc Ctr Frankfurt, DZHK Partner Site Rhine Main, Frankfurt, Germany
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Linneberg, Allan (författare)
- Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark
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- Lorenz, Thiess (författare)
- Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany
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- Lyngbakken, Magnus Nakrem (författare)
- Akershus Univ Hosp, Div Med, Dept Cardiol, Lorenskog, Norway;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Cardiac Biomarkers, Fac Med, Oslo, Norway
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- Malekzadeh, Reza (författare)
- Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Liver & Pancreaticobiliary Dis Res Ctr, Tehran, Iran;Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Digest Oncol Res Ctr, Tehran, Iran;Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Digest Dis Res Ctr, Tehran, Iran
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- Malyutina, Sofia (författare)
- Russian Acad Sci, Res Inst Internal & Prevent Med, Branch Fed Res Ctr Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia
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- Mathiesen, Ellisiv B. (författare)
- Arctic Univ Norway, Univ Tromso, Dept Clin Med, Tromso, Norway
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- Melander, Olle (författare)
- Lund Univ, Dept Clin Sci Malmö, Malmö, Sweden
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- Metspalu, Andres (författare)
- Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia
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- Risérus, Ulf, 1967- (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Blankenberg, Stefan (författare)
- Univ Med Ctr Hamburg Eppendorf, Dept Cardiol, Univ Heart & Vasc Ctr, Ctr Populat Hlth Innovat, Martinistr 52, D-20246 Hamburg, Germany University of Hamburg;University Medical Center Hamburg-Eppendorf
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(creator_code:org_t)
- Massachusetts Medical Society, 2023
- 2023
- Engelska.
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Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 389:14, s. 1273-1285
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.)Harmonized individual-level data from a global cohort showed that more than half the cases of incident cardiovascular disease and one fifth of deaths may be attributable to five modifiable risk factors.
Nyckelord
- Cardiovascular disease
- Cardiovascular risk factors
- Risk factor modification
- Global
- Population-attributable fraction
- Geographical comparison
- Myocardial infarction
- Coronary heart disease
- Stroke
- Heart disease
- Nutrition
- Nutrition
- Nutrition
- Nutrition
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Magnussen, Chris ...
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Ojeda, Francisco ...
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Leong, Darryl P.
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Alegre-Diaz, Jes ...
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Amouyel, Philipp ...
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Aviles-Santa, La ...
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visa fler...
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De Bacquer, Dirk
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Ballantyne, Chri ...
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Bernabé-Ortiz, A ...
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Bobak, Martin
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Brenner, Hermann
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Carrillo-Larco, ...
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de Lemos, James
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Dobson, Annette
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Dörr, Marcus
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Donfrancesco, Ch ...
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Drygas, Wojciech
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Dullaart, Robin ...
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Engström, Gunnar
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Ferrario, Marco ...
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Ferrières, Jean
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de Gaetano, Giov ...
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Goldbourt, Uri
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Gonzalez, Clicer ...
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Grassi, Guido
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Hodge, Allison M ...
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Hveem, Kristian
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Iacoviello, Lici ...
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Ikram, M. Kamran
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Irazola, Vilma
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Jobe, Modou
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Jousilahti, Pekk ...
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Kaleebu, Pontian ...
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Kavousi, Maryam
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Kee, Frank
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Khalili, Davood
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Koenig, Wolfgang
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Kontsevaya, Anna
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Kuulasmaa, Kari
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Lackner, Karl J.
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Leistner, David ...
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Lind, Lars
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Linneberg, Allan
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Lorenz, Thiess
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Lyngbakken, Magn ...
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Malekzadeh, Reza
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Malyutina, Sofia
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Mathiesen, Ellis ...
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Melander, Olle
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Metspalu, Andres
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Risérus, Ulf, 19 ...
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Blankenberg, Ste ...
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Uppsala universitet