Sökning: WFRF:(Lyngbakken Magnus N.) > Circulating Secreto...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05946naa a2200469 4500 | |
001 | oai:DiVA.org:uu-387601 | |
003 | SwePub | |
008 | 190626s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3876012 URI |
024 | 7 | a https://doi.org/10.1097/CCM.00000000000036702 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Brynildsen, Jonu Akershus Univ Hosp, Div Med, Sykehusveien 25, N-1478 Lorenskog, Norway;Univ Oslo, Inst Clin Med, Ctr Heart Failure Res, Oslo, Norway4 aut |
245 | 1 0 | a Circulating Secretoneurin Concentrations After Cardiac Surgery :b Data From the FINNish Acute Kidney Injury Heart Study |
264 | 1 | c 2019 |
338 | a print2 rdacarrier | |
520 | a Objectives:Secretoneurin is associated with cardiomyocyte Ca2+ handling and improves risk prediction in patients with acute myocardial dysfunction. Whether secretoneurin improves risk assessment on top of established cardiac biomarkers and European System for Cardiac Operative Risk Evaluation II in patients undergoing cardiac surgery is not known.Design:Prospective, observational, single-center sub-study of a multicenter study.Setting:Prospective observational study of survival in patients undergoing cardiac surgery.Patients:A total of 619 patients undergoing cardiac surgery.Interventions:Patients underwent either isolated coronary artery bypass graft surgery, single noncoronary artery bypass graft surgery, two procedures, or three or more procedures. Procedures other than coronary artery bypass graft were valve surgery, surgery on thoracic aorta, and other cardiac surgery.Measurements and Main Results:We measured preoperative and postoperative secretoneurin concentrations and adjusted for European System for Cardiac Operative Risk Evaluation II, N-terminal pro-B-type natriuretic peptide, and cardiac troponin T concentrations in multivariate analyses. During 961 days of follow- up, 59 patients died (9.5%). Secretoneurin concentrations were higher among nonsurvivors compared with survivors, both before (168 pmol/L [quartile 1-3, 147-206 pmol/L] vs 160 pmol/L [131-193 pmol/L]; p = 0.039) and after cardiac surgery (173 pmol/L [129-217 pmol/L] vs 143 pmol/L [111-173 pmol/L]; p < 0.001). Secretoneurin concentrations decreased from preoperative to postoperative measurements in survivors, whereas we observed no significant decrease in secretoneurin concentrations among nonsurvivors. Secretoneurin concentrations were weakly correlated with established risk indices. Patients with the highest postoperative secretoneurin concentrations had worse outcome compared with patients with lower secretoneurin concentrations (p < 0.001 by the log-rank test) and postoperative secretoneurin concentrations were associated with time to death in multivariate Cox regression analysis: hazard ratio ln secretoneurin 2.96 (95% CI, 1.46-5.99; p = 0.003). Adding postoperative secretoneurin concentrations to European System for Cardiac Operative Risk Evaluation II improved patient risk stratification, as assessed by the integrated discrimination index: 0.023 (95% CI, 0.0043-0.041; p = 0.016).Conclusions:Circulating postoperative secretoneurin concentrations provide incremental prognostic information to established risk indices in patients undergoing cardiac surgery. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng |
653 | a biomarkers | |
653 | a cardiac surgery | |
653 | a coronary artery bypass graft | |
653 | a European System for Cardiac Operative Risk Evaluation II | |
653 | a risk assessment | |
653 | a secretoneurin | |
700 | 1 | a Petaja, Liisau Univ Helsinki, Div Anaesthesiol Intens Care & Pain Med, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland4 aut |
700 | 1 | a Myhre, Peder L.u Akershus Univ Hosp, Div Med, Sykehusveien 25, N-1478 Lorenskog, Norway;Univ Oslo, Inst Clin Med, Ctr Heart Failure Res, Oslo, Norway4 aut |
700 | 1 | a Lyngbakken, Magnus N.u Akershus Univ Hosp, Div Med, Sykehusveien 25, N-1478 Lorenskog, Norway;Univ Oslo, Inst Clin Med, Ctr Heart Failure Res, Oslo, Norway4 aut |
700 | 1 | a Nygard, Staleu Oslo Univ Hosp, Bioinformat Core Facil, Inst Med Informat, Oslo, Norway;Univ Oslo, Oslo, Norway4 aut |
700 | 1 | a Stridsberg, Matsu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)matsstri |
700 | 1 | a Christensen, Geiru Univ Oslo, Inst Clin Med, Ctr Heart Failure Res, Oslo, Norway;Oslo Univ Hosp, Expt Med Res Inst, Oslo, Norway4 aut |
700 | 1 | a Ottesen, Anett H.u Akershus Univ Hosp, Div Med, Sykehusveien 25, N-1478 Lorenskog, Norway;Univ Oslo, Inst Clin Med, Ctr Heart Failure Res, Oslo, Norway;Oslo Univ Hosp, Expt Med Res Inst, Oslo, Norway4 aut |
700 | 1 | a Pettila, Villeu Univ Helsinki, Div Anaesthesiol Intens Care & Pain Med, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland4 aut |
700 | 1 | a Omland, Torbjornu Akershus Univ Hosp, Div Med, Sykehusveien 25, N-1478 Lorenskog, Norway;Univ Oslo, Inst Clin Med, Ctr Heart Failure Res, Oslo, Norway4 aut |
700 | 1 | a Rosjo, Helgeu Akershus Univ Hosp, Div Med, Sykehusveien 25, N-1478 Lorenskog, Norway;Univ Oslo, Inst Clin Med, Ctr Heart Failure Res, Oslo, Norway4 aut |
710 | 2 | a Akershus Univ Hosp, Div Med, Sykehusveien 25, N-1478 Lorenskog, Norway;Univ Oslo, Inst Clin Med, Ctr Heart Failure Res, Oslo, Norwayb Univ Helsinki, Div Anaesthesiol Intens Care & Pain Med, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland4 org |
773 | 0 | t Critical Care Medicineg 47:5, s. E412-E419q 47:5<E412-E419x 0090-3493x 1530-0293 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-387601 |
856 | 4 8 | u https://doi.org/10.1097/CCM.0000000000003670 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.