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Global spatial dyna...
Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis
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- Lefrancq, Noemie (författare)
- Univ Paris Cite, Math Modelling Infect Dis Unit, CNRS, UMR2000,Inst Pasteur, F-75015 Paris, France.;Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England.
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- Bouchez, Valerie (författare)
- Univ Paris Cite, Inst Pasteur, Biodivers & Epidemiol Bacterial Pathogens, F-75724 Paris, France.;Natl Reference Ctr Whooping Cough & Other Bordete, F-75724 Paris, France.
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- Fernandes, Nadia (författare)
- Univ Paris Cite, Inst Pasteur, Biodivers & Epidemiol Bacterial Pathogens, F-75724 Paris, France.
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- Barkoff, Alex-Mikael (författare)
- Univ Turku UTU, Res Ctr Infect & Immun, Inst Biomed, FI-20520 Turku, Finland.
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- Bosch, Thijs (författare)
- Ctr Infect Dis Control, Natl Inst Publ Hlth & Environm RIVM, NL-3720 BA Bilthoven, Netherlands.
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- Dalby, Tine (författare)
- Statens Serum Inst, Bacteria Parasites & Fungi Infect Dis Preparednes, DK-2300 Copenhagen, Denmark.
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- Akerlund, Thomas (författare)
- Publ Hlth Agcy Sweden, Unit Lab Surveillance Bacterial Pathogens, SE-17182 Solna, Sweden.
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- Darenberg, Jessica (författare)
- Publ Hlth Agcy Sweden, Unit Lab Surveillance Bacterial Pathogens, SE-17182 Solna, Sweden.
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- Fabianova, Katerina (författare)
- Natl Inst Publ Hlth, Dept Infect Dis Epidemiol, CZ-10000 Prague, Czech Republic.
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- Vestrheim, Didrik F. (författare)
- Norwegian Inst Publ Hlth, Dept Infect Dis Control & Vaccine, N-0213 Oslo, Norway.
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- Fry, Norman K. (författare)
- Publ Hlth England, Resp & Vaccine Preventable Bacteria Reference Uni, Natl Infect Serv, London NW9 5EQ, England.;Publ Hlth England, Immunisat & Countermeasures Div, Natl Infect Serv, London NW9 5EQ, England.
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- Jose Gonzalez-Lopez, Juan (författare)
- Univ Hosp Vall dHebron, Microbiol Dept, Barcelona 08035, Spain.;Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona 08193, Spain.
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- Gullsby, Karolina (författare)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg
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- Habington, Adele (författare)
- Childrens Hlth Ireland, Mol Microbiol Lab, Dublin D12 N512, Ireland.
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- He, Qiushui (författare)
- Univ Turku UTU, Res Ctr Infect & Immun, Inst Biomed, FI-20520 Turku, Finland.;Univ Turku, InFLAMES Res Flagship Ctr, FI-20520 Turku, Finland.
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- Litt, David (författare)
- Publ Hlth England, Resp & Vaccine Preventable Bacteria Reference Uni, Natl Infect Serv, London NW9 5EQ, England.
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- Martini, Helena (författare)
- Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel, Natl Reference Ctr Bordetella Pertussis, Dept Microbiol, B-1090 Brussels, Belgium.
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- Pierard, Denis (författare)
- Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel, Natl Reference Ctr Bordetella Pertussis, Dept Microbiol, B-1090 Brussels, Belgium.
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- Stefanelli, Paola (författare)
- Ist Super Sanita, Dept Infect Dis, IT-00161 Rome, Italy.
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- Stegger, Marc (författare)
- Statens Serum Inst, Bacteria Parasites & Fungi Infect Dis Preparednes, DK-2300 Copenhagen, Denmark.
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- Zavadilova, Jana (författare)
- Natl Inst Publ Hlth, Natl Reference Lab Pertussis & Diphtheria, Prague 10000, Czech Republic.
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- Armatys, Nathalie (författare)
- Univ Paris Cite, Inst Pasteur, Biodivers & Epidemiol Bacterial Pathogens, F-75724 Paris, France.;Natl Reference Ctr Whooping Cough & Other Bordete, F-75724 Paris, France.
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- Landier, Annie (författare)
- Univ Paris Cite, Inst Pasteur, Biodivers & Epidemiol Bacterial Pathogens, F-75724 Paris, France.;Natl Reference Ctr Whooping Cough & Other Bordete, F-75724 Paris, France.
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- Guillot, Sophie (författare)
- Univ Paris Cite, Inst Pasteur, Biodivers & Epidemiol Bacterial Pathogens, F-75724 Paris, France.;Natl Reference Ctr Whooping Cough & Other Bordete, F-75724 Paris, France.
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- Hong, Samuel L. (författare)
- Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Rega Inst, B-3000 Leuven, Belgium.
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- Lemey, Philippe (författare)
- Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Rega Inst, B-3000 Leuven, Belgium.
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- Parkhill, Julian (författare)
- Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England.
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- Toubiana, Julie (författare)
- Univ Paris Cite, Inst Pasteur, Biodivers & Epidemiol Bacterial Pathogens, F-75724 Paris, France.;Natl Reference Ctr Whooping Cough & Other Bordete, F-75724 Paris, France.;Univ Paris Cite, Necker Enfants Malad Hosp, AP HP, Dept Gen Paediat & Paediat Infect Dis, F-75015 Paris, France.
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- Cauchemez, Simon (författare)
- Univ Paris Cite, Math Modelling Infect Dis Unit, CNRS, UMR2000,Inst Pasteur, F-75015 Paris, France.
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- Salje, Henrik (författare)
- Univ Paris Cite, Math Modelling Infect Dis Unit, CNRS, UMR2000,Inst Pasteur, F-75015 Paris, France.;Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England.
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- Brisse, Sylvain (författare)
- Univ Paris Cite, Inst Pasteur, Biodivers & Epidemiol Bacterial Pathogens, F-75724 Paris, France.;Natl Reference Ctr Whooping Cough & Other Bordete, F-75724 Paris, France.
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Univ Paris Cite, Math Modelling Infect Dis Unit, CNRS, UMR2000,Inst Pasteur, F-75015 Paris, France;Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England. Univ Paris Cite, Inst Pasteur, Biodivers & Epidemiol Bacterial Pathogens, F-75724 Paris, France.;Natl Reference Ctr Whooping Cough & Other Bordete, F-75724 Paris, France. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2022
- 2022
- Engelska.
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 14:642
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Lefrancq, Noemie
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Bouchez, Valerie
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Fernandes, Nadia
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Barkoff, Alex-Mi ...
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Bosch, Thijs
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Dalby, Tine
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visa fler...
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Akerlund, Thomas
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Darenberg, Jessi ...
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Fabianova, Kater ...
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Vestrheim, Didri ...
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Fry, Norman K.
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Jose Gonzalez-Lo ...
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Gullsby, Karolin ...
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Habington, Adele
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He, Qiushui
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Litt, David
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Martini, Helena
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Pierard, Denis
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Stefanelli, Paol ...
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Stegger, Marc
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Zavadilova, Jana
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Armatys, Nathali ...
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Landier, Annie
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Guillot, Sophie
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Hong, Samuel L.
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Lemey, Philippe
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Parkhill, Julian
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Toubiana, Julie
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Cauchemez, Simon
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Salje, Henrik
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Brisse, Sylvain
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